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FGB
Description
fibrinogen beta chain
Image
GO Annotations
Cellular Component
Extracellular Region
Fibrinogen Complex
Extracellular Space
Endoplasmic Reticulum
Plasma Membrane
Cell Cortex
External Side Of Plasma Membrane
Cell Surface
Platelet Alpha Granule
Platelet Alpha Granule Lumen
Synapse
Collagen-containing Extracellular Matrix
Extracellular Exosome
Blood Microparticle
Extracellular Vesicle
Molecular Function
Signaling Receptor Binding
Structural Molecule Activity
Extracellular Matrix Structural Constituent
Protein Binding
Cell Adhesion Molecule Binding
Chaperone Binding
Biological Process
Toll-like Receptor Signaling Pathway
Adaptive Immune Response
Platelet Degranulation
Cell Adhesion
Cell-matrix Adhesion
Blood Coagulation
Extracellular Matrix Organization
Plasminogen Activation
Positive Regulation Of Heterotypic Cell-cell Adhesion
Cellular Protein-containing Complex Assembly
Fibrinolysis
Induction Of Bacterial Agglutination
Cellular Response To Leptin Stimulus
Innate Immune Response
Positive Regulation Of Vasoconstriction
Positive Regulation Of Exocytosis
Positive Regulation Of Protein Secretion
Protein Polymerization
Response To Calcium Ion
Positive Regulation Of ERK1 And ERK2 Cascade
Platelet Aggregation
Cellular Response To Interleukin-1
Blood Coagulation, Fibrin Clot Formation
Positive Regulation Of Peptide Hormone Secretion
Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Negative Regulation Of Endothelial Cell Apoptotic Process
Pathways
Platelet degranulation
Common Pathway of Fibrin Clot Formation
Integrin cell surface interactions
Integrin signaling
GRB2:SOS provides linkage to MAPK signaling for Integrins
p130Cas linkage to MAPK signaling for integrins
MAP2K and MAPK activation
Regulation of TLR by endogenous ligand
Signaling by moderate kinase activity BRAF mutants
Signaling by high-kinase activity BRAF mutants
Signaling by BRAF and RAF fusions
Paradoxical activation of RAF signaling by kinase inactive BRAF
Signaling downstream of RAS mutants
Signaling by RAF1 mutants
Drugs
Sucralfate
Alfimeprase
Thrombin
Prothrombin
Human thrombin
Thrombin alfa
Anti-inhibitor coagulant complex
Diseases
Afibrinogenemia; Dysfibrinogenemia
Inherited thrombophilia
GWAS
Chronic obstructive pulmonary disease-related biomarkers (
23144326
)
Fibrinogen (
20031576
20031577
23969696
21757653
)
Fibrinogen levels (
29403010
28107422
26561523
)
Ischemic stroke (
29531354
)
Interacting Genes
16 interacting genes:
AIMP2
ANXA7
APP
CALR
CDKN1A
CSNK2B
FBLN1
FGA
FGG
GRB7
LPA
NID1
PIK3R3
SERPINA5
SMN1
TK1
Entrez ID
2244
HPRD ID
00620
Ensembl ID
ENSG00000171564
Uniprot IDs
P02675
V9HVY1
PDB IDs
1FZA
1FZB
1FZC
1FZE
1FZF
1FZG
1LT9
1LTJ
1N86
1N8E
1RE3
1RE4
1RF0
1RF1
2A45
2FFD
2H43
2HLO
2HOD
2HPC
2OYH
2OYI
2Q9I
2XNX
2XNY
2Z4E
3BVH
3E1I
3GHG
3H32
3HUS
6ATZ
6BIJ
6BIL
Enriched GO Terms of Interacting Partners
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