TGM1 and LCE3A

Data Source:
BioGRID (two hybrid)

		TGM1	LCE3A
Description		transglutaminase 1	late cornified envelope 3A
Image			No pdb structure
GO Annotations	Cellular Component	Cornified Envelope Cytosol Plasma Membrane Membrane Intrinsic Component Of Membrane Extracellular Exosome
	Molecular Function	Protein-glutamine Gamma-glutamyltransferase Activity Protein Binding Identical Protein Binding Metal Ion Binding	Protein Binding
	Biological Process	Cellular Protein Modification Process Positive Regulation Of Keratinocyte Proliferation Peptide Cross-linking Protein Phosphopantetheinylation Keratinocyte Differentiation Cell Envelope Organization Positive Regulation Of Cell Cycle Cornification	Keratinization Killing Of Cells Of Other Organism Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium
Pathways		Formation of the cornified envelope	Formation of the cornified envelope
Drugs
Diseases		Lamellar ichthyosis (LI) and Non-bullous congenital ichthyosiform erythroderma (NBCIE)
GWAS			Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic dermatitis ( 23727859) Inflammatory skin disease ( 25574825) Psoriasis ( 19169255) Psoriasis vulgaris ( 26626624)
Interacting Genes		34 interacting genes: ACADL ALPP C1QTNF1 CNNM3 CRCT1 CXCL16 DOCK2 GSTP1 HSPB1 IFI30 IGSF8 ITGB4 JOSD1 KRTAP4-12 KRTAP5-9 LCE1B LCE1E LCE3A LCE4A MDK MYPOP NECTIN2 NUBP2 PLAAT4 RIN3 SCARF1 SEMG1 SEMG2 SNCA SULT4A1 TACC2 TRAPPC14 VASN VSTM4	61 interacting genes: ADAMTSL4 ALPP CHIC2 CYSRT1 EFEMP1 EFEMP2 FBLN1 KRTAP1-3 KRTAP1-5 KRTAP10-1 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP12-3 KRTAP12-4 KRTAP17-1 KRTAP2-3 KRTAP2-4 KRTAP3-1 KRTAP3-2 KRTAP3-3 KRTAP4-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-2 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-7 KRTAP5-9 KRTAP6-3 KRTAP9-2 KRTAP9-3 KRTAP9-8 LCE1C LCE2A LCE2B LCE2C LCE3B MACO1 MDFI NBPF19 NOTCH2NLA OIT3 PLSCR2 RGS17 RGS20 SMCP SPRY1 SPRY3 TGFB1 TGM1 TRIM42 TSPAN4 VWC2 VWC2L
Entrez ID		7051	353142
HPRD ID		01824	13973
Ensembl ID		ENSG00000092295	ENSG00000185962
Uniprot IDs		P22735	Q5TA76
PDB IDs		2XZZ
Enriched GO Terms of Interacting Partners?
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