TGM1 and CNNM3

Data Source:
BioGRID (two hybrid)

		TGM1	CNNM3
Description		transglutaminase 1	cyclin and CBS domain divalent metal cation transport mediator 3
Image
GO Annotations	Cellular Component	Cornified Envelope Cytosol Plasma Membrane Membrane Intrinsic Component Of Membrane Extracellular Exosome	Plasma Membrane Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Protein-glutamine Gamma-glutamyltransferase Activity Protein Binding Identical Protein Binding Metal Ion Binding	Protein Binding Transmembrane Transporter Activity
	Biological Process	Cellular Protein Modification Process Positive Regulation Of Keratinocyte Proliferation Peptide Cross-linking Protein Phosphopantetheinylation Keratinocyte Differentiation Cell Envelope Organization Positive Regulation Of Cell Cycle Cornification	Transport Ion Transport Transmembrane Transport
Pathways		Formation of the cornified envelope
Drugs
Diseases		Lamellar ichthyosis (LI) and Non-bullous congenital ichthyosiform erythroderma (NBCIE)
GWAS			Bipolar disorder ( 31043756) Birth weight ( 31043758) Erectile dysfunction and prostate cancer treatment ( 20932654) Offspring birth weight ( 31043758)
Interacting Genes		34 interacting genes: ACADL ALPP C1QTNF1 CNNM3 CRCT1 CXCL16 DOCK2 GSTP1 HSPB1 IFI30 IGSF8 ITGB4 JOSD1 KRTAP4-12 KRTAP5-9 LCE1B LCE1E LCE3A LCE4A MDK MYPOP NECTIN2 NUBP2 PLAAT4 RIN3 SCARF1 SEMG1 SEMG2 SNCA SULT4A1 TACC2 TRAPPC14 VASN VSTM4	71 interacting genes: ACTN2 AGR2 AGR3 AKAP8L CALCOCO2 CARD10 CBY2 CCNDBP1 COG6 CYSRT1 EFEMP2 EXOSC8 FHL3 FHL5 GOLGA6L9 HNRNPK HOXA1 HSF2BP KHDRBS2 KHDRBS3 KPRP KRT31 KRT33B KRT40 KRTAP1-1 KRTAP1-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-2 KRTAP12-3 KRTAP17-1 KRTAP2-4 KRTAP3-1 KRTAP3-2 KRTAP4-12 KRTAP5-9 KRTAP6-3 KRTAP9-2 KRTAP9-3 KRTAP9-8 LZTS2 MDFI MID2 MTUS2 NBPF19 NOTCH2NLA P4HB PM20D2 PNMA1 PNMA2 PNMA3 PTP4A2 RBMX RBMY1F RBMY1J RBPMS RELA SRSF3 SSC4D TGM1 TNS2 TRIM27 UBE2G2 UBQLN2 USHBP1 VWC2 WWOX ZNF330 ZRANB1
Entrez ID		7051	26505
HPRD ID		01824	07419
Ensembl ID		ENSG00000092295	ENSG00000168763
Uniprot IDs		P22735	Q8NE01
PDB IDs		2XZZ	5K22 5K23 5K25 5TSR 6DFD 6MN6 6WUR
Enriched GO Terms of Interacting Partners?
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