TGM1 and IFI30

Data Source:
BioGRID (two hybrid)

		TGM1	IFI30
Description		transglutaminase 1	IFI30 lysosomal thiol reductase
Image			No pdb structure
GO Annotations	Cellular Component	Cornified Envelope Cytosol Plasma Membrane Membrane Intrinsic Component Of Membrane Extracellular Exosome	Extracellular Region Lysosome Cytosol Cell Junction Lysosomal Lumen Intracellular Membrane-bounded Organelle
	Molecular Function	Protein-glutamine Gamma-glutamyltransferase Activity Protein Binding Identical Protein Binding Metal Ion Binding	Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On A Sulfur Group Of Donors
	Biological Process	Cellular Protein Modification Process Positive Regulation Of Keratinocyte Proliferation Peptide Cross-linking Protein Phosphopantetheinylation Keratinocyte Differentiation Cell Envelope Organization Positive Regulation Of Cell Cycle Cornification	Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Negative Regulation Of Fibroblast Proliferation Protein Stabilization Interferon-gamma-mediated Signaling Pathway
Pathways		Formation of the cornified envelope	MHC class II antigen presentation Interferon gamma signaling
Drugs
Diseases		Lamellar ichthyosis (LI) and Non-bullous congenital ichthyosiform erythroderma (NBCIE)
GWAS			Mental health study participation (completed survey) ( 31263887) Multiple sclerosis ( 31604244 24076602) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)
Interacting Genes		34 interacting genes: ACADL ALPP C1QTNF1 CNNM3 CRCT1 CXCL16 DOCK2 GSTP1 HSPB1 IFI30 IGSF8 ITGB4 JOSD1 KRTAP4-12 KRTAP5-9 LCE1B LCE1E LCE3A LCE4A MDK MYPOP NECTIN2 NUBP2 PLAAT4 RIN3 SCARF1 SEMG1 SEMG2 SNCA SULT4A1 TACC2 TRAPPC14 VASN VSTM4	3 interacting genes: KRTAP4-12 NOTCH2NLA TGM1
Entrez ID		7051	10437
HPRD ID		01824	05234
Ensembl ID		ENSG00000092295	ENSG00000216490
Uniprot IDs		P22735	A0A024R7N7 P13284
PDB IDs		2XZZ
Enriched GO Terms of Interacting Partners?
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