TGM1 and SEMG2

Data Source:
HPRD (in vitro)

		TGM1	SEMG2
Description		transglutaminase 1	semenogelin 2
Image			No pdb structure
GO Annotations	Cellular Component	Cornified Envelope Cytosol Plasma Membrane Membrane Intrinsic Component Of Membrane Extracellular Exosome	Extracellular Space Nucleus Extracellular Exosome
	Molecular Function	Protein-glutamine Gamma-glutamyltransferase Activity Protein Binding Identical Protein Binding Metal Ion Binding	Protease Binding Protein Binding Zinc Ion Binding
	Biological Process	Cellular Protein Modification Process Positive Regulation Of Keratinocyte Proliferation Peptide Cross-linking Protein Phosphopantetheinylation Keratinocyte Differentiation Cell Envelope Organization Positive Regulation Of Cell Cycle Cornification	Antibacterial Humoral Response Sperm Capacitation Coagulation Positive Regulation Of Serine-type Endopeptidase Activity Negative Regulation Of Flagellated Sperm Motility
Pathways		Formation of the cornified envelope
Drugs			Zinc chloride Zinc sulfate, unspecified form
Diseases		Lamellar ichthyosis (LI) and Non-bullous congenital ichthyosiform erythroderma (NBCIE)
GWAS			Asthma ( 29273806) Bipolar disorder ( 31043756) Blood protein levels ( 28240269) Malaria ( 31844061)
Interacting Genes		34 interacting genes: ACADL ALPP C1QTNF1 CNNM3 CRCT1 CXCL16 DOCK2 GSTP1 HSPB1 IFI30 IGSF8 ITGB4 JOSD1 KRTAP4-12 KRTAP5-9 LCE1B LCE1E LCE3A LCE4A MDK MYPOP NECTIN2 NUBP2 PLAAT4 RIN3 SCARF1 SEMG1 SEMG2 SNCA SULT4A1 TACC2 TRAPPC14 VASN VSTM4	8 interacting genes: KLK2 KLK3 PRKAR2A PRKCA PTPRF SEMG1 SERPINA5 TGM1
Entrez ID		7051	6407
HPRD ID		01824	01642
Ensembl ID		ENSG00000092295	ENSG00000124157
Uniprot IDs		P22735	Q02383
PDB IDs		2XZZ
Enriched GO Terms of Interacting Partners?
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