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CNNM3 and EXOSC8
Data Source:
BioGRID
(two hybrid)
CNNM3
EXOSC8
Description
cyclin and CBS domain divalent metal cation transport mediator 3
exosome component 8
Image
GO Annotations
Cellular Component
Plasma Membrane
Membrane
Integral Component Of Membrane
Intracellular Membrane-bounded Organelle
Nuclear Exosome (RNase Complex)
Cytoplasmic Exosome (RNase Complex)
Exosome (RNase Complex)
Fibrillar Center
Nucleus
Nucleoplasm
Chromosome
Cytoplasm
Cytosol
Intracellular Membrane-bounded Organelle
Molecular Function
Protein Binding
Transmembrane Transporter Activity
Exoribonuclease Activity
Protein Binding
MRNA 3'-UTR AU-rich Region Binding
Identical Protein Binding
Biological Process
Transport
Ion Transport
Transmembrane Transport
Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA)
RRNA Processing
Biological_process
RRNA Catabolic Process
Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5'
U1 SnRNA 3'-end Processing
U4 SnRNA 3'-end Processing
U5 SnRNA 3'-end Processing
Regulation Of MRNA Stability
Exonucleolytic Catabolism Of Deadenylated MRNA
Nuclear MRNA Surveillance
Nuclear Polyadenylation-dependent RRNA Catabolic Process
Nuclear Polyadenylation-dependent TRNA Catabolic Process
Nuclear Polyadenylation-dependent MRNA Catabolic Process
Pathways
ATF4 activates genes in response to endoplasmic reticulum stress
mRNA decay by 3' to 5' exoribonuclease
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
KSRP (KHSRP) binds and destabilizes mRNA
Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS
Bipolar disorder (
31043756
)
Birth weight (
31043758
)
Erectile dysfunction and prostate cancer treatment (
20932654
)
Offspring birth weight (
31043758
)
Interacting Genes
71 interacting genes:
ACTN2
AGR2
AGR3
AKAP8L
CALCOCO2
CARD10
CBY2
CCNDBP1
COG6
CYSRT1
EFEMP2
EXOSC8
FHL3
FHL5
GOLGA6L9
HNRNPK
HOXA1
HSF2BP
KHDRBS2
KHDRBS3
KPRP
KRT31
KRT33B
KRT40
KRTAP1-1
KRTAP1-3
KRTAP10-5
KRTAP10-7
KRTAP10-8
KRTAP10-9
KRTAP12-2
KRTAP12-3
KRTAP17-1
KRTAP2-4
KRTAP3-1
KRTAP3-2
KRTAP4-12
KRTAP5-9
KRTAP6-3
KRTAP9-2
KRTAP9-3
KRTAP9-8
LZTS2
MDFI
MID2
MTUS2
NBPF19
NOTCH2NLA
P4HB
PM20D2
PNMA1
PNMA2
PNMA3
PTP4A2
RBMX
RBMY1F
RBMY1J
RBPMS
RELA
SRSF3
SSC4D
TGM1
TNS2
TRIM27
UBE2G2
UBQLN2
USHBP1
VWC2
WWOX
ZNF330
ZRANB1
74 interacting genes:
AEN
ATF2
C22orf39
CCDC28A-AS1
CNNM3
COL23A1
COX5A
CRMP1
CWC22
DDIT4L
DIS3
DUSP23
EXOSC1
EXOSC10
EXOSC2
EXOSC4
EXOSC5
EXOSC6
EXOSC7
EXOSC9
FAM161B
FAM90A1
FHOD1
FOXD4L1
FOXN3
FRG1
GEM
HAPLN2
HOXB9
INCA1
KANK2
KCNJ11
LMO4
LNX1
LSM1
LSM4
LSM7
MACIR
MKRN1
MORN4
MPHOSPH6
MTREX
MYOZ1
NEDD9
NTAQ1
OTUD4
PALS2
PHF21A
PIAS2
POLDIP3
RASD1
RASSF1
REL
RFC5
RPP14
RUSC1
RXRB
SLAIN1
SNAI1
SNRPB
SNRPC
SOCS7
SPATC1L
TCEA2
TFAP4
TXNDC17
TXNDC9
UBC
UPF2
USP2
USP6
XRN1
XRN2
ZFP36
Entrez ID
26505
11340
HPRD ID
07419
09351
Ensembl ID
ENSG00000168763
ENSG00000120699
Uniprot IDs
Q8NE01
Q96B26
PDB IDs
5K22
5K23
5K25
5TSR
6DFD
6MN6
6WUR
2NN6
6D6Q
6D6R
6H25
Enriched GO Terms of Interacting Partners
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