IFI30 and TGM1

Data Source:
BioGRID (two hybrid)

		IFI30	TGM1
Description		IFI30 lysosomal thiol reductase	transglutaminase 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Lysosome Cytosol Cell Junction Lysosomal Lumen Intracellular Membrane-bounded Organelle	Cornified Envelope Cytosol Plasma Membrane Membrane Intrinsic Component Of Membrane Extracellular Exosome
	Molecular Function	Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On A Sulfur Group Of Donors	Protein-glutamine Gamma-glutamyltransferase Activity Protein Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Negative Regulation Of Fibroblast Proliferation Protein Stabilization Interferon-gamma-mediated Signaling Pathway	Cellular Protein Modification Process Positive Regulation Of Keratinocyte Proliferation Peptide Cross-linking Protein Phosphopantetheinylation Keratinocyte Differentiation Cell Envelope Organization Positive Regulation Of Cell Cycle Cornification
Pathways		MHC class II antigen presentation Interferon gamma signaling	Formation of the cornified envelope
Drugs
Diseases			Lamellar ichthyosis (LI) and Non-bullous congenital ichthyosiform erythroderma (NBCIE)
GWAS		Mental health study participation (completed survey) ( 31263887) Multiple sclerosis ( 31604244 24076602) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)
Interacting Genes		3 interacting genes: KRTAP4-12 NOTCH2NLA TGM1	34 interacting genes: ACADL ALPP C1QTNF1 CNNM3 CRCT1 CXCL16 DOCK2 GSTP1 HSPB1 IFI30 IGSF8 ITGB4 JOSD1 KRTAP4-12 KRTAP5-9 LCE1B LCE1E LCE3A LCE4A MDK MYPOP NECTIN2 NUBP2 PLAAT4 RIN3 SCARF1 SEMG1 SEMG2 SNCA SULT4A1 TACC2 TRAPPC14 VASN VSTM4
Entrez ID		10437	7051
HPRD ID		05234	01824
Ensembl ID		ENSG00000216490	ENSG00000092295
Uniprot IDs		A0A024R7N7 P13284	P22735
PDB IDs			2XZZ
Enriched GO Terms of Interacting Partners?
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