TEAD1 and MYH7

Data Source:
HPRD (in vitro, two hybrid)

		TEAD1	MYH7
Description		TEA domain transcription factor 1	myosin heavy chain 7
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GO Annotations	Cellular Component	Chromatin Nucleoplasm Transcription Regulator Complex TEAD-YAP Complex	Stress Fiber Muscle Myosin Complex Myosin Complex Myofibril Sarcomere Z Disc Myosin Filament
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding	Microfilament Motor Activity Protein Binding Calmodulin Binding ATP Binding ATPase Activity Actin-dependent ATPase Activity Actin Filament Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Hippo Signaling Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Embryonic Organ Development Protein-containing Complex Assembly Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II	Regulation Of The Force Of Heart Contraction Regulation Of Heart Rate Skeletal Muscle Contraction Muscle Contraction Striated Muscle Contraction Adult Heart Development Regulation Of The Force Of Skeletal Muscle Contraction Transition Between Fast And Slow Fiber Cardiac Muscle Hypertrophy In Response To Stress Muscle Filament Sliding Regulation Of Slow-twitch Skeletal Muscle Fiber Contraction ATP Metabolic Process Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Contraction
Pathways		YAP1- and WWTR1 (TAZ)-stimulated gene expression RUNX3 regulates YAP1-mediated transcription EGR2 and SOX10-mediated initiation of Schwann cell myelination
Drugs			4-[4-(2,5-DIOXO-PYRROLIDIN-1-YL)-PHENYLAMINO]-4-HYDROXY-BUTYRIC ACID
Diseases			Distal muscular dystrophies, including: Welander distal myopathy (WDM); Tibial muscular dystrophy (TMD); Nonaka distal myopathy with rimmed vacuoles (DMRV); Miyoshi myopathy (MM); Laing myopathy (MPD1); Distal nebulin myopathy (DNM); Distal desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Distal myotilinopathy (MFM3); Distal zaspopathy (MFM4); Distal myopathy 3 (MPD2, VCPDM) Hypertrophic cardiomyopathy (HCM) Myosin storage myopathy (MSM); Hyaline body myopathy Scapuloperoneal myopathy (SPM) Dilated cardiomyopathy (DCM)
GWAS		Central retinal vein equivalent ( 26567291) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Diisocyanate-induced asthma ( 25918132) Gut microbiota relative abundance (unclassified genus belonging to family Erysipelotrichaceae) ( 33208821) HDL cholesterol levels x loop diuretics use interaction ( 31806883) Heel bone mineral density ( 30598549) Height ( 28552196 20881960 25282103) HOMA-B (corrected for HOMA-IR) ( 30369944) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Neutrophil count ( 32888494)	Atrial fibrillation ( 30061737 29892015) Resting heart rate ( 27798624 20639392)
Interacting Genes		21 interacting genes: BORCS8-MEF2B ENO1 GCAT HLA-DMB INSR MAX MEF2A MEF2C MYH7 NCOA1 SRF TBP TRIM3 UBTD1 VGLL1 VGLL2 VGLL3 VGLL4 WWTR1 YAP1 ZDHHC17	12 interacting genes: CHRM5 CLVS2 DISC1 KXD1 MYOM2 RND1 RNF167 SNAPIN TEAD1 TEAD3 TEAD4 TULP3
Entrez ID		7003	4625
HPRD ID		01802	01175
Ensembl ID		ENSG00000187079	ENSG00000092054
Uniprot IDs		P28347 Q59EF3	P12883
PDB IDs		2HZD 3KYS 4RE1 4Z8E 5NNX 6HIL 6IM5	1IK2 2FXM 2FXO 3DTP 4DB1 4P7H 4PA0 4XA1 4XA3 4XA4 4XA6 5CHX 5CJ0 5CJ1 5CJ4 5TBY 5WJ7 5WJB 5WLQ 5WLZ 5WME 6PF2 6PFP
Enriched GO Terms of Interacting Partners?
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