MYH7 and TEAD4

Data Source:
HPRD (in vitro, two hybrid)

		MYH7	TEAD4
Description		myosin heavy chain 7	TEA domain transcription factor 4
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GO Annotations	Cellular Component	Stress Fiber Muscle Myosin Complex Myosin Complex Myofibril Sarcomere Z Disc Myosin Filament	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex
	Molecular Function	Microfilament Motor Activity Protein Binding Calmodulin Binding ATP Binding ATPase Activity Actin-dependent ATPase Activity Actin Filament Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding
	Biological Process	Regulation Of The Force Of Heart Contraction Regulation Of Heart Rate Skeletal Muscle Contraction Muscle Contraction Striated Muscle Contraction Adult Heart Development Regulation Of The Force Of Skeletal Muscle Contraction Transition Between Fast And Slow Fiber Cardiac Muscle Hypertrophy In Response To Stress Muscle Filament Sliding Regulation Of Slow-twitch Skeletal Muscle Fiber Contraction ATP Metabolic Process Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Contraction	Skeletal System Development Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Muscle Organ Development Hippo Signaling Embryonic Organ Development
Pathways			YAP1- and WWTR1 (TAZ)-stimulated gene expression RUNX3 regulates YAP1-mediated transcription
Drugs		4-[4-(2,5-DIOXO-PYRROLIDIN-1-YL)-PHENYLAMINO]-4-HYDROXY-BUTYRIC ACID
Diseases		Distal muscular dystrophies, including: Welander distal myopathy (WDM); Tibial muscular dystrophy (TMD); Nonaka distal myopathy with rimmed vacuoles (DMRV); Miyoshi myopathy (MM); Laing myopathy (MPD1); Distal nebulin myopathy (DNM); Distal desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Distal myotilinopathy (MFM3); Distal zaspopathy (MFM4); Distal myopathy 3 (MPD2, VCPDM) Hypertrophic cardiomyopathy (HCM) Myosin storage myopathy (MSM); Hyaline body myopathy Scapuloperoneal myopathy (SPM) Dilated cardiomyopathy (DCM)
GWAS		Atrial fibrillation ( 30061737 29892015) Resting heart rate ( 27798624 20639392)	Narcolepsy with cataplexy ( 23496005)
Interacting Genes		12 interacting genes: CHRM5 CLVS2 DISC1 KXD1 MYOM2 RND1 RNF167 SNAPIN TEAD1 TEAD3 TEAD4 TULP3	50 interacting genes: CCDC125 CCDC172 CCDC85B CCNDBP1 CDR2 CEP55 CEP70 CTBP1 DYDC1 EXOC3-AS1 FBXO7 GOLGA2 GOLGA6L9 HAUS1 HOMEZ INCA1 KIAA0753 KRT27 KRT31 KRT40 KRTAP10-3 LDOC1 LZTS2 MDFI MTUS2 MYH7 NUTM1 PDE4DIP PFKM PNMA1 PRDM14 PRKAR1B RABGEF1 RASSF10 RUNDC3A RUNX1 SAT1 SESTD1 SORBS3 SSX2IP TLE5 TRAF1 TRIM27 TRIM54 VGLL1 VGLL3 VPS52 VTA1 WWTR1 YAP1
Entrez ID		4625	7004
HPRD ID		01175	03421
Ensembl ID		ENSG00000092054	ENSG00000197905
Uniprot IDs		P12883	Q15561
PDB IDs		1IK2 2FXM 2FXO 3DTP 4DB1 4P7H 4PA0 4XA1 4XA3 4XA4 4XA6 5CHX 5CJ0 5CJ1 5CJ4 5TBY 5WJ7 5WJB 5WLQ 5WLZ 5WME 6PF2 6PFP	5GZB 5NO6 5OAQ 6GE3 6GE4 6GE5 6GE6 6GEC 6GEE 6GEG 6GEI 6GEK 6HIK 6Q2X 6Q36 6SEN 6SEO
Enriched GO Terms of Interacting Partners?
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