MYH7 and CLVS2

Data Source:
BioGRID (two hybrid)

		MYH7	CLVS2
Description		myosin heavy chain 7	clavesin 2
Image			No pdb structure
GO Annotations	Cellular Component	Stress Fiber Muscle Myosin Complex Myosin Complex Myofibril Sarcomere Z Disc Myosin Filament	Endosome Trans-Golgi Network Clathrin-coated Vesicle Early Endosome Membrane Trans-Golgi Network Membrane
	Molecular Function	Microfilament Motor Activity Protein Binding Calmodulin Binding ATP Binding ATPase Activity Actin-dependent ATPase Activity Actin Filament Binding	Protein Binding Phosphatidylinositol-3,5-bisphosphate Binding Phosphatidylinositol Bisphosphate Binding
	Biological Process	Regulation Of The Force Of Heart Contraction Regulation Of Heart Rate Skeletal Muscle Contraction Muscle Contraction Striated Muscle Contraction Adult Heart Development Regulation Of The Force Of Skeletal Muscle Contraction Transition Between Fast And Slow Fiber Cardiac Muscle Hypertrophy In Response To Stress Muscle Filament Sliding Regulation Of Slow-twitch Skeletal Muscle Fiber Contraction ATP Metabolic Process Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Contraction	Lysosome Organization
Pathways			Lysosome Vesicle Biogenesis
Drugs		4-[4-(2,5-DIOXO-PYRROLIDIN-1-YL)-PHENYLAMINO]-4-HYDROXY-BUTYRIC ACID
Diseases		Distal muscular dystrophies, including: Welander distal myopathy (WDM); Tibial muscular dystrophy (TMD); Nonaka distal myopathy with rimmed vacuoles (DMRV); Miyoshi myopathy (MM); Laing myopathy (MPD1); Distal nebulin myopathy (DNM); Distal desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Distal myotilinopathy (MFM3); Distal zaspopathy (MFM4); Distal myopathy 3 (MPD2, VCPDM) Hypertrophic cardiomyopathy (HCM) Myosin storage myopathy (MSM); Hyaline body myopathy Scapuloperoneal myopathy (SPM) Dilated cardiomyopathy (DCM)
GWAS		Atrial fibrillation ( 30061737 29892015) Resting heart rate ( 27798624 20639392)	Refractive error ( 32231278)
Interacting Genes		12 interacting genes: CHRM5 CLVS2 DISC1 KXD1 MYOM2 RND1 RNF167 SNAPIN TEAD1 TEAD3 TEAD4 TULP3	16 interacting genes: EMSY FBXW2 FLAD1 GSTM3 GSTZ1 GYS1 KAZN MEOX2 MYH7 PAFAH1B2 PCYT2 PGAM2 PHETA2 S100A7 S100A7A TACC2
Entrez ID		4625	134829
HPRD ID		01175	16666
Ensembl ID		ENSG00000092054	ENSG00000146352
Uniprot IDs		P12883	Q5SYC1
PDB IDs		1IK2 2FXM 2FXO 3DTP 4DB1 4P7H 4PA0 4XA1 4XA3 4XA4 4XA6 5CHX 5CJ0 5CJ1 5CJ4 5TBY 5WJ7 5WJB 5WLQ 5WLZ 5WME 6PF2 6PFP
Enriched GO Terms of Interacting Partners?
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