TEAD1 and TRIM3

Data Source:
BioGRID (two hybrid)

		TEAD1	TRIM3
Description		TEA domain transcription factor 1	tripartite motif containing 3
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleoplasm Transcription Regulator Complex TEAD-YAP Complex	Cytoplasm Early Endosome Golgi Apparatus Dendrite
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding	Protein Binding Protein C-terminus Binding Zinc Ion Binding Identical Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Hippo Signaling Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Embryonic Organ Development Protein-containing Complex Assembly Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II	Protein Polyubiquitination Nervous System Development Protein Transport Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways		YAP1- and WWTR1 (TAZ)-stimulated gene expression RUNX3 regulates YAP1-mediated transcription EGR2 and SOX10-mediated initiation of Schwann cell myelination	Interferon gamma signaling
Drugs
Diseases
GWAS		Central retinal vein equivalent ( 26567291) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Diisocyanate-induced asthma ( 25918132) Gut microbiota relative abundance (unclassified genus belonging to family Erysipelotrichaceae) ( 33208821) HDL cholesterol levels x loop diuretics use interaction ( 31806883) Heel bone mineral density ( 30598549) Height ( 28552196 20881960 25282103) HOMA-B (corrected for HOMA-IR) ( 30369944) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Neutrophil count ( 32888494)	Malaria ( 31844061)
Interacting Genes		21 interacting genes: BORCS8-MEF2B ENO1 GCAT HLA-DMB INSR MAX MEF2A MEF2C MYH7 NCOA1 SRF TBP TRIM3 UBTD1 VGLL1 VGLL2 VGLL3 VGLL4 WWTR1 YAP1 ZDHHC17	30 interacting genes: ACTN4 ASL CDKN1A CEP70 CSNK1D CSNK1E KCTD7 KIF21B LNX1 LRRC8E MYO5A MYO5B ROPN1 TEAD1 TEAD2 TNFAIP3 TPTEP2-CSNK1E TRIM2 TRIM21 UBE2D1 UBE2D2 UBE2D4 UBE2E1 UBE2E2 UBE2G2 UBE2I UBE2K UBE2U UBE2Z USP32
Entrez ID		7003	10612
HPRD ID		01802	05690
Ensembl ID		ENSG00000187079	ENSG00000110171
Uniprot IDs		P28347 Q59EF3	B7Z5Y8 O75382
PDB IDs		2HZD 3KYS 4RE1 4Z8E 5NNX 6HIL 6IM5
Enriched GO Terms of Interacting Partners?
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