TEAD1 and ENO1

Data Source:
BioGRID (two hybrid)

		TEAD1	ENO1
Description		TEA domain transcription factor 1	enolase 1
Image
GO Annotations	Cellular Component	Chromatin Nucleoplasm Transcription Regulator Complex TEAD-YAP Complex	Phosphopyruvate Hydratase Complex Extracellular Space Nucleus Cytoplasm Cytosol Plasma Membrane Cell Surface Membrane M Band Extracellular Exosome Cell Cortex Region
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific Double-stranded DNA Binding	Magnesium Ion Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific RNA Binding Phosphopyruvate Hydratase Activity Protein Binding Protein Homodimerization Activity Cadherin Binding GTPase Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Hippo Signaling Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Embryonic Organ Development Protein-containing Complex Assembly Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II	Negative Regulation Of Transcription By RNA Polymerase II Gluconeogenesis Glycolytic Process Response To Virus Positive Regulation Of Plasminogen Activation Negative Regulation Of Cell Growth Regulation Of Vacuole Fusion, Non-autophagic Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Muscle Contraction Canonical Glycolysis Negative Regulation Of Hypoxia-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of ATP Biosynthetic Process
Pathways		YAP1- and WWTR1 (TAZ)-stimulated gene expression RUNX3 regulates YAP1-mediated transcription EGR2 and SOX10-mediated initiation of Schwann cell myelination	Glycolysis Gluconeogenesis Manipulation of host energy metabolism
Drugs			Zinc Copper Artenimol Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Central retinal vein equivalent ( 26567291) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Diisocyanate-induced asthma ( 25918132) Gut microbiota relative abundance (unclassified genus belonging to family Erysipelotrichaceae) ( 33208821) HDL cholesterol levels x loop diuretics use interaction ( 31806883) Heel bone mineral density ( 30598549) Height ( 28552196 20881960 25282103) HOMA-B (corrected for HOMA-IR) ( 30369944) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Neutrophil count ( 32888494)	Asthma ( 30929738) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Blood protein levels ( 30072576) Feeling tense ( 29500382) Platelet count ( 32888494) Plateletcrit ( 32888494 27863252) Tonsillectomy ( 27182965 28928442) White blood cell count ( 32888494) White blood cell count (basophil) ( 27863252)
Interacting Genes		21 interacting genes: BORCS8-MEF2B ENO1 GCAT HLA-DMB INSR MAX MEF2A MEF2C MYH7 NCOA1 SRF TBP TRIM3 UBTD1 VGLL1 VGLL2 VGLL3 VGLL4 WWTR1 YAP1 ZDHHC17	59 interacting genes: AGTPBP1 ALDOA AMBP ARID1B BCL6 BHLHE40 BRCA1 CBX5 CHEK2 CLK1 COL14A1 CYSLTR2 DES DUX4 FANCA FHL1 FLNC FYN GLIS3 GRB2 HDAC1 HEMGN HEY2 HK2 HSP90AB1 HSPA8 HSPB2 ITGB1 IVNS1ABP KDM2A LIG4 LINC01554 LONRF3 MCPH1 MED13 MYOC NCOR1 P4HB PAF1 PCNA PLG PPP2R5E RXFP3 SERPING1 SET SGCG SNAPC3 SRC SUMO2 SUMO4 TCAP TEAD1 TERT TRAPPC2 TTN UPF2 YWHAQ YWHAZ ZBTB44
Entrez ID		7003	2023
HPRD ID		01802	01400
Ensembl ID		ENSG00000187079	ENSG00000074800
Uniprot IDs		P28347 Q59EF3	A0A024R4F1 P06733
PDB IDs		2HZD 3KYS 4RE1 4Z8E 5NNX 6HIL 6IM5	2PSN 3B97 5JLZ 5LAX 5NI9 5NIG 5OCK
Enriched GO Terms of Interacting Partners?
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