TDO2 and NR1D1

Data Source:
BioGRID (two hybrid)

		TDO2	NR1D1
Description		tryptophan 2,3-dioxygenase	nuclear receptor subfamily 1 group D member 1
Image
GO Annotations	Cellular Component	Cytosol	Chromatin Nucleus Nucleoplasm Cytoplasm Nuclear Body Dendrite Dendritic Spine
	Molecular Function	Tryptophan 2,3-dioxygenase Activity Protein Binding Amino Acid Binding Oxygen Binding Heme Binding Identical Protein Binding Metal Ion Binding	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Corepressor Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Steroid Hormone Receptor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Heme Binding E-box Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Tryptophan Catabolic Process Tryptophan Catabolic Process To Kynurenine Tryptophan Catabolic Process To Acetyl-CoA Protein Homotetramerization Response To Nitroglycerin	Negative Regulation Of Transcription By RNA Polymerase II Cellular Glucose Homeostasis Glycogen Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Circadian Rhythm Hormone-mediated Signaling Pathway Proteasomal Protein Catabolic Process Regulation Of Lipid Metabolic Process Cell Differentiation Intracellular Receptor Signaling Pathway Protein Destabilization Circadian Regulation Of Gene Expression Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Cholesterol Homeostasis Regulation Of Circadian Sleep/wake Cycle Regulation Of Circadian Rhythm Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Steroid Hormone Mediated Signaling Pathway Response To Leptin Regulation Of Fat Cell Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Inflammatory Response Circadian Temperature Homeostasis Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Regulation Of Type B Pancreatic Cell Proliferation Negative Regulation Of Astrocyte Activation Positive Regulation Of Bile Acid Biosynthetic Process Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Negative Regulation Of Cold-induced Thermogenesis Negative Regulation Of Neuroinflammatory Response Negative Regulation Of Microglial Cell Activation
Pathways		Tryptophan catabolism	NR1D1 (REV-ERBA) represses gene expression PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Nuclear Receptor transcription pathway Circadian Clock Circadian Clock
Drugs			SR-9009 SR-9011
Diseases
GWAS		Blood metabolite levels ( 24816252) Manganese levels ( 26025379) Speech perception in dyslexia ( 19786962)	Asthma ( 31619474) Mean corpuscular volume ( 32888494) Multiple sclerosis ( 31604244) White blood cell count ( 21738480)
Interacting Genes		20 interacting genes: ASMTL DPM1 EIF4E KDM1A LMNA LNX1 MEOX2 MOB1A MOB3C NGB NMNAT1 NR1D1 PICK1 PM20D2 PRMT6 PSMA1 REL SDCBP SDCBP2 ZFYVE26	9 interacting genes: APP C1D INPP1 NCOR1 NCOR2 NR1D2 NR2E3 SPG21 TDO2
Entrez ID		6999	9572
HPRD ID		01847	03873
Ensembl ID		ENSG00000151790	ENSG00000126368
Uniprot IDs		P48775	F1D8S3 P20393
PDB IDs		4PW8 5TI9 5TIA 6A4I 6PYY 6PYZ 6VBN	1A6Y 1EF6 1GA5 1HLZ 3N00
Enriched GO Terms of Interacting Partners?
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