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STAT3 and PDGFRB
Data Source:
HPRD
(in vitro)
STAT3
PDGFRB
Description
signal transducer and activator of transcription 3
platelet derived growth factor receptor beta
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Cytoplasm
Cytosol
Plasma Membrane
RNA Polymerase II Transcription Regulator Complex
Nucleus
Cytoplasm
Golgi Apparatus
Plasma Membrane
Integral Component Of Plasma Membrane
Focal Adhesion
Cell Surface
Membrane
Apical Plasma Membrane
Intrinsic Component Of Plasma Membrane
Cytoplasmic Vesicle
Lysosomal Lumen
Intracellular Membrane-bounded Organelle
Receptor Complex
Molecular Function
Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
RNA Polymerase II Repressing Transcription Factor Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
DNA-binding Transcription Factor Activity
Nuclear Receptor Activity
Protein Binding
Transcription Factor Binding
Protein Kinase Binding
Protein Phosphatase Binding
Chromatin DNA Binding
Identical Protein Binding
Protein Homodimerization Activity
Protein Dimerization Activity
Primary MiRNA Binding
Protein Tyrosine Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
Platelet Activating Factor Receptor Activity
Platelet-derived Growth Factor-activated Receptor Activity
Platelet-derived Growth Factor Beta-receptor Activity
Signaling Receptor Binding
Platelet-derived Growth Factor Receptor Binding
Protein Binding
ATP Binding
Growth Factor Binding
Enzyme Binding
Protein Kinase Binding
Vascular Endothelial Growth Factor Binding
Phosphatidylinositol 3-kinase Binding
Platelet-derived Growth Factor Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Temperature Homeostasis
Eye Photoreceptor Cell Differentiation
Regulation Of Transcription, DNA-templated
Regulation Of Transcription By RNA Polymerase II
Protein Import Into Nucleus
Defense Response
Inflammatory Response
Signal Transduction
Receptor Signaling Pathway Via JAK-STAT
Nervous System Development
Negative Regulation Of Autophagy
Positive Regulation Of Gene Expression
Viral Process
Phosphorylation
Cytokine-mediated Signaling Pathway
Sexual Reproduction
Positive Regulation Of Cell Migration
Intracellular Receptor Signaling Pathway
Response To Estradiol
Positive Regulation Of Interleukin-1 Beta Production
Positive Regulation Of Interleukin-10 Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Interleukin-8 Production
Positive Regulation Of Tumor Necrosis Factor Production
Cellular Response To Hormone Stimulus
Leptin-mediated Signaling Pathway
Somatic Stem Cell Population Maintenance
Interleukin-15-mediated Signaling Pathway
Interleukin-7-mediated Signaling Pathway
Interleukin-9-mediated Signaling Pathway
Interleukin-21-mediated Signaling Pathway
Interleukin-23-mediated Signaling Pathway
Regulation Of Cell Population Proliferation
Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein
Glucose Homeostasis
Eating Behavior
Response To Peptide Hormone
Cellular Response To Leptin Stimulus
Response To Leptin
Positive Regulation Of Erythrocyte Differentiation
Positive Regulation Of Notch Signaling Pathway
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Astrocyte Differentiation
Positive Regulation Of NF-kappaB Transcription Factor Activity
Regulation Of Cell Cycle
Radial Glial Cell Differentiation
Regulation Of Feeding Behavior
Growth Hormone Receptor Signaling Pathway
Growth Hormone Receptor Signaling Pathway Via JAK-STAT
Interleukin-6-mediated Signaling Pathway
Interleukin-27-mediated Signaling Pathway
Interleukin-35-mediated Signaling Pathway
Cellular Response To Cytokine Stimulus
T-helper 17 Type Immune Response
T-helper 17 Cell Lineage Commitment
Energy Homeostasis
Positive Regulation Of Cytokine Production Involved In Inflammatory Response
Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II
Positive Regulation Of Metalloendopeptidase Activity
Positive Regulation Of MiRNA Mediated Inhibition Of Translation
Negative Regulation Of Primary MiRNA Processing
Positive Regulation Of Gene Silencing By MiRNA
MAPK Cascade
Glycosaminoglycan Biosynthetic Process
Signal Transduction
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
G Protein-coupled Receptor Signaling Pathway
Multicellular Organism Development
Aging
Positive Regulation Of Cell Population Proliferation
Male Gonad Development
Response To Toxic Substance
Positive Regulation Of Phospholipase C Activity
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Positive Regulation Of Smooth Muscle Cell Migration
Cell Migration
Peptidyl-tyrosine Phosphorylation
Positive Regulation Of Cell Migration
Response To Estradiol
Positive Regulation Of Phosphoprotein Phosphatase Activity
Response To Retinoic Acid
Regulation Of Actin Cytoskeleton Organization
Positive Regulation Of Collagen Biosynthetic Process
Positive Regulation Of Kinase Activity
Response To Fluid Shear Stress
Positive Regulation Of Rho Protein Signal Transduction
Cell Migration Involved In Vasculogenesis
Metanephric Mesenchymal Cell Migration
Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Aorta Morphogenesis
Cellular Response To Platelet-derived Growth Factor Stimulus
Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway
Wound Healing
Response To Hydrogen Peroxide
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Positive Regulation Of MAP Kinase Activity
Positive Regulation Of Phosphatidylinositol 3-kinase Activity
Response To Estrogen
Positive Regulation Of Mitotic Nuclear Division
Phosphatidylinositol Metabolic Process
Protein Autophosphorylation
Platelet-derived Growth Factor Receptor Signaling Pathway
Phosphatidylinositol-mediated Signaling
Positive Regulation Of Fibroblast Proliferation
Positive Regulation Of Smooth Muscle Cell Proliferation
Inner Ear Development
Positive Regulation Of Chemotaxis
Positive Regulation Of Protein Kinase B Signaling
Cardiac Myofibril Assembly
Response To Hyperoxia
Cell Chemotaxis
Lung Growth
Cell Migration Involved In Coronary Angiogenesis
Retina Vasculature Development In Camera-type Eye
Positive Regulation Of ERK1 And ERK2 Cascade
Smooth Muscle Cell Chemotaxis
Metanephric Mesenchyme Development
Metanephric Glomerular Mesangial Cell Proliferation Involved In Metanephros Development
Metanephric Glomerular Capillary Formation
Metanephric Comma-shaped Body Morphogenesis
Metanephric S-shaped Body Morphogenesis
Positive Regulation Of Calcium Ion Import
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Positive Regulation Of Hepatic Stellate Cell Activation
Positive Regulation Of DNA Biosynthetic Process
Pathways
Interleukin-6 signaling
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
Interleukin-7 signaling
Interleukin-7 signaling
Signaling by SCF-KIT
Signaling by cytosolic FGFR1 fusion mutants
Downstream signal transduction
Signalling to STAT3
Senescence-Associated Secretory Phenotype (SASP)
Signaling by Leptin
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
Association of TriC/CCT with target proteins during biosynthesis
Transcriptional regulation of pluripotent stem cells
Interleukin-10 signaling
Interleukin-4 and Interleukin-13 signaling
PTK6 Activates STAT3
PTK6 Activates STAT3
Interleukin-20 family signaling
MET activates STAT3
MET activates STAT3
Interleukin-15 signaling
Interleukin-35 Signalling
Interleukin-9 signaling
Interleukin-37 signaling
Interleukin-23 signaling
Interleukin-23 signaling
Interleukin-27 signaling
Interleukin-21 signaling
Transcriptional regulation of granulopoiesis
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants
Signaling by PDGFRA extracellular domain mutants
Growth hormone receptor signaling
PIP3 activates AKT signaling
Downstream signal transduction
Signaling by PDGF
Constitutive Signaling by Aberrant PI3K in Cancer
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Drugs
ENMD-1198
Becaplermin
Sorafenib
Imatinib
Dasatinib
Sunitinib
XL999
XL820
Pazopanib
Midostaurin
Regorafenib
Nintedanib
Polaprezinc
Trapidil
Foreskin fibroblast (neonatal)
Fostamatinib
Erdafitinib
Pexidartinib
Ripretinib
Pralsetinib
Diseases
Other well-defined immunodeficiency syndromes, including the following seven diseases: Wiskott-Aldrich syndrome; DiGeorge syndrome; Hyper-IgE syndrome; X-linked lymphoproliferative syndrome; Immunodeficiency, Polyendocrinopathy, Enteropathy, X-linked Syndrome (IPEX); Cartilage-Hair Hypoplasia; Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)
Oral cancer
Glioma
GWAS
Apolipoprotein B levels (
32203549
)
Atopic dermatitis (
26482879
)
Autoimmune thyroid disease (
32581359
)
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Composite immunoglobulin trait (IgA/IgG) (
28628107
)
Crohn's disease (
18587394
28067908
21102463
23266558
)
Crohn's disease or systemic sclerosis (
32024964
)
Diastolic blood pressure (
30578418
)
Inflammatory bowel disease (
27569725
28067908
26278503
23128233
)
Itch intensity from mosquito bite (
28199695
)
Itch intensity from mosquito bite adjusted by bite size (
28199695
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
27863252
)
Mean spheric corpuscular volume (
32888494
)
Multiple sclerosis (
31604244
22190364
24076602
21833088
20159113
)
Psoriasis (
25903422
23143594
)
Systemic lupus erythematosus (
28714469
)
Type 2 diabetes (
30054458
)
Ulcerative colitis (
28067908
)
Blood protein levels (
30072576
29875488
28240269
)
Cytokine network levels (multivariate analysis) (
31679650
)
Granulocyte percentage of myeloid white cells (
27863252
)
Inflammatory biomarkers (multivariate analysis) (
33110245
)
Monocyte count (
27863252
)
Monocyte percentage of white cells (
32888494
27863252
)
Interacting Genes
208 interacting genes:
ABL2
ADRB2
AMBP
AR
ARFIP2
ASXL1
ATF3
BATF3
BCKDK
BHLHE40
BICD1
BLK
BMX
BRCA1
BRWD1
CA8
CAPN1
CAPNS1
CBL
CCDC87
CCND1
CCR1
CCR5
CDK9
CDKN1A
CEP120
CHTF18
CNDP2
CORO1A
CREBBP
CSF2RB
CSF3R
CXCR4
DAXX
DOK2
DOK3
DTNA
ECH1
EGFR
EIF2AK2
ELP2
EP300
EPHA3
ERBB2
ERBIN
ESR1
FAM117B
FBXW7
FER
FES
FGFR3
FGFR4
FGR
FHL2
FLT1
FOXM1
FYN
GATA1
GATA2
GHR
GNL3
GSTCD
GTF2I
HCK
HDAC1
HDAC2
HDAC3
HES1
HES5
HESX1
HIF1A
HIVEP1
HLA-A
HNF1A
HNRNPM
HOXC11
HSP90AA1
HSP90AB1
IFNAR1
IFNAR2
IGF1R
IL1RAP
IL22RA1
IL23R
IL2RA
IL2RB
IL6R
IL6ST
IL7R
IMPDH2
IRAK1
JAK1
JAK2
JAK3
JUN
KAT5
KDM1A
KHDRBS1
KLF15
KPNA1
KPNA6
KRTAP10-7
LAMB2
LASP1
LCK
LEPR
LMO2
LYN
MAP3K13
MAP3K7
MAPK1
MAPK3
MAPK8
MAPKAPK2
MEG3
MET
MNDA
MORC4
MPZL1
MRPS31
MTOR
MYOD1
NACAD
NCOA1
NDUFA13
NFKB1
NFKBIZ
NIF3L1
NLK
NMI
NR3C1
NR4A1
NUFIP2
NXT2
OFCC1
OGDHL
PAFAH1B2
PAQR7
PCBD2
PDGFRA
PDGFRB
PDIA3
PELP1
PIAS3
PIK3R1
PIK3R2
PIK3R3
PINK1
PML
POM121
PPARD
PRKCD
PTK2B
PTMA
PTPN1
PTPN11
PTPN2
RABGAP1
RAC1
RACK1
RB1
RELA
RET
RPA2
RPL11
RPS6KA5
RPS9
RRAD
SCAF11
SETD7
SH2D2A
SH3BP2
SIAH2
SIN3A
SMARCA4
SPRY1
SRC
SRI
SRRT
SS18L1
STAP2
STAT1
STAT4
STAT5A
STAT5B
STAT6
STMN1
SULT2A1
SUMO4
SUPT20H
SYK
TASOR2
TDG
TM4SF19
TRIM28
TRIP10
TSHR
TSLP
TWIST1
VPS39
WDFY3
ZFPM2
ZNF148
ZNF281
ZNF467
ZNF557
ZNF829
ZNRD2
76 interacting genes:
ABL1
ABL2
ARAF
BAG1
CAV1
CAV3
CBL
CEP76
COPA
COPB1
CRK
EGFR
EIF2AK2
ERBB2
FGFR1
FYN
GAB1
GRB10
GRB14
GRB2
GRB7
ITGB3
JAK1
JAK2
KLHL12
KPRP
KRT31
KRT34
KRTAP10-9
KRTAP12-3
KRTAP4-12
NCK1
NCK2
NEDD4
PDAP1
PDGFB
PDGFD
PDGFRA
PIK3C2B
PIK3CA
PIK3R1
PIK3R2
PIK3R3
PLCG1
PPM1L
PRDX2
PTEN
PTK2
PTPN1
PTPN11
PTPN2
PTPN6
PTPRJ
RAF1
RASA1
RPS6KB2
S1PR1
SHC1
SLC9A3R1
SLC9A3R2
SNX1
SNX2
SNX4
SOCS1
SRC
STAT1
STAT3
STAT5A
STAT5B
SYNGAP1
TNK2
TPTE
TRIP6
TYK2
VAV1
YES1
Entrez ID
6774
5159
HPRD ID
00026
01423
Ensembl ID
ENSG00000168610
ENSG00000113721
Uniprot IDs
P40763
P09619
Q59F04
PDB IDs
5AX3
5U5S
6NJS
6NUQ
6QHD
6TLC
1GQ5
1H9O
1LWP
1SHA
2IUI
2L6W
2PLD
2PLE
3MJG
Enriched GO Terms of Interacting Partners
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