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STAT3 and ERBB2
Data Source:
BioGRID
(affinity chromatography technology, unspecified method)
STAT3
ERBB2
Description
signal transducer and activator of transcription 3
erb-b2 receptor tyrosine kinase 2
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Cytoplasm
Cytosol
Plasma Membrane
RNA Polymerase II Transcription Regulator Complex
Nucleus
Early Endosome
Cytosol
Plasma Membrane
Integral Component Of Plasma Membrane
Basal Plasma Membrane
Endosome Membrane
Integral Component Of Membrane
Basolateral Plasma Membrane
Apical Plasma Membrane
ERBB3:ERBB2 Complex
Myelin Sheath
Receptor Complex
Perinuclear Region Of Cytoplasm
Molecular Function
Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
RNA Polymerase II Repressing Transcription Factor Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
DNA-binding Transcription Factor Activity
Nuclear Receptor Activity
Protein Binding
Transcription Factor Binding
Protein Kinase Binding
Protein Phosphatase Binding
Chromatin DNA Binding
Identical Protein Binding
Protein Homodimerization Activity
Protein Dimerization Activity
Primary MiRNA Binding
RNA Polymerase I Core Binding
Protein Tyrosine Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
Transmembrane Signaling Receptor Activity
Protein Binding
ATP Binding
Protein C-terminus Binding
Growth Factor Binding
Protein Phosphatase Binding
Identical Protein Binding
ErbB-3 Class Receptor Binding
Protein Heterodimerization Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Temperature Homeostasis
Eye Photoreceptor Cell Differentiation
Regulation Of Transcription, DNA-templated
Regulation Of Transcription By RNA Polymerase II
Protein Import Into Nucleus
Defense Response
Inflammatory Response
Signal Transduction
Receptor Signaling Pathway Via JAK-STAT
Nervous System Development
Negative Regulation Of Autophagy
Positive Regulation Of Gene Expression
Viral Process
Phosphorylation
Cytokine-mediated Signaling Pathway
Sexual Reproduction
Positive Regulation Of Cell Migration
Intracellular Receptor Signaling Pathway
Response To Estradiol
Positive Regulation Of Interleukin-1 Beta Production
Positive Regulation Of Interleukin-10 Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Interleukin-8 Production
Positive Regulation Of Tumor Necrosis Factor Production
Cellular Response To Hormone Stimulus
Leptin-mediated Signaling Pathway
Somatic Stem Cell Population Maintenance
Interleukin-15-mediated Signaling Pathway
Interleukin-7-mediated Signaling Pathway
Interleukin-9-mediated Signaling Pathway
Interleukin-21-mediated Signaling Pathway
Interleukin-23-mediated Signaling Pathway
Regulation Of Cell Population Proliferation
Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein
Glucose Homeostasis
Eating Behavior
Response To Peptide Hormone
Cellular Response To Leptin Stimulus
Response To Leptin
Positive Regulation Of Erythrocyte Differentiation
Positive Regulation Of Notch Signaling Pathway
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Astrocyte Differentiation
Positive Regulation Of NF-kappaB Transcription Factor Activity
Regulation Of Cell Cycle
Radial Glial Cell Differentiation
Regulation Of Feeding Behavior
Growth Hormone Receptor Signaling Pathway
Growth Hormone Receptor Signaling Pathway Via JAK-STAT
Interleukin-6-mediated Signaling Pathway
Interleukin-27-mediated Signaling Pathway
Interleukin-35-mediated Signaling Pathway
Cellular Response To Cytokine Stimulus
T-helper 17 Type Immune Response
T-helper 17 Cell Lineage Commitment
Energy Homeostasis
Positive Regulation Of Cytokine Production Involved In Inflammatory Response
Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II
Positive Regulation Of Metalloendopeptidase Activity
Positive Regulation Of MiRNA Mediated Inhibition Of Translation
Negative Regulation Of Primary MiRNA Processing
Positive Regulation Of Gene Silencing By MiRNA
MAPK Cascade
Positive Regulation Of Protein Phosphorylation
Regulation Of Transcription By RNA Polymerase II
Protein Phosphorylation
Signal Transduction
Cell Surface Receptor Signaling Pathway
Enzyme Linked Receptor Protein Signaling Pathway
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Multicellular Organism Development
Peripheral Nervous System Development
Heart Development
Neuromuscular Junction Development
Motor Neuron Axon Guidance
Positive Regulation Of Cell Population Proliferation
Phosphatidylinositol 3-kinase Signaling
Peptidyl-tyrosine Phosphorylation
Neuron Differentiation
Positive Regulation Of Cell Growth
Regulation Of Microtubule-based Process
Negative Regulation Of Immature T Cell Proliferation In Thymus
Positive Regulation Of Kinase Activity
Intracellular Signal Transduction
ERBB2 Signaling Pathway
Wound Healing
Myelination
Positive Regulation Of MAP Kinase Activity
Positive Regulation Of MAPK Cascade
Positive Regulation Of GTPase Activity
Positive Regulation Of Translation
Regulation Of Angiogenesis
Positive Regulation Of Cell Adhesion
Positive Regulation Of Transcription By RNA Polymerase I
Protein Autophosphorylation
Oligodendrocyte Differentiation
Positive Regulation Of Epithelial Cell Proliferation
Positive Regulation Of Protein Kinase B Signaling
Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Growth Factor Stimulus
Cellular Response To Epidermal Growth Factor Stimulus
Positive Regulation Of Protein Targeting To Membrane
Negative Regulation Of ERBB Signaling Pathway
Regulation Of Cell Motility
Pathways
Interleukin-6 signaling
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
Interleukin-7 signaling
Interleukin-7 signaling
Signaling by SCF-KIT
Signaling by cytosolic FGFR1 fusion mutants
Downstream signal transduction
Signalling to STAT3
Senescence-Associated Secretory Phenotype (SASP)
Signaling by Leptin
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
Association of TriC/CCT with target proteins during biosynthesis
Transcriptional regulation of pluripotent stem cells
Interleukin-10 signaling
Interleukin-4 and Interleukin-13 signaling
PTK6 Activates STAT3
PTK6 Activates STAT3
Interleukin-20 family signaling
MET activates STAT3
MET activates STAT3
Interleukin-15 signaling
Interleukin-35 Signalling
Interleukin-9 signaling
Interleukin-37 signaling
Interleukin-23 signaling
Interleukin-23 signaling
Interleukin-27 signaling
Interleukin-21 signaling
Transcriptional regulation of granulopoiesis
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants
Signaling by PDGFRA extracellular domain mutants
Growth hormone receptor signaling
Signaling by ERBB2
SHC1 events in ERBB2 signaling
SHC1 events in ERBB2 signaling
PLCG1 events in ERBB2 signaling
PIP3 activates AKT signaling
GRB7 events in ERBB2 signaling
Downregulation of ERBB2:ERBB3 signaling
GRB2 events in ERBB2 signaling
GRB2 events in ERBB2 signaling
PI3K events in ERBB2 signaling
Constitutive Signaling by Aberrant PI3K in Cancer
Sema4D induced cell migration and growth-cone collapse
RAF/MAP kinase cascade
ERBB2 Regulates Cell Motility
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
ERBB2 Activates PTK6 Signaling
Downregulation of ERBB2 signaling
TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
Constitutive Signaling by Overexpressed ERBB2
Drug-mediated inhibition of ERBB2 signaling
Signaling by ERBB2 KD Mutants
Resistance of ERBB2 KD mutants to trastuzumab
Resistance of ERBB2 KD mutants to sapitinib
Resistance of ERBB2 KD mutants to tesevatinib
Resistance of ERBB2 KD mutants to neratinib
Resistance of ERBB2 KD mutants to osimertinib
Resistance of ERBB2 KD mutants to afatinib
Resistance of ERBB2 KD mutants to AEE788
Resistance of ERBB2 KD mutants to lapatinib
Signaling by ERBB2 ECD mutants
Signaling by ERBB2 TMD/JMD mutants
Drug resistance in ERBB2 TMD/JMD mutants
Drugs
ENMD-1198
Trastuzumab
Lapatinib
IGN311
Trastuzumab emtansine
Varlitinib
AV-412
Pertuzumab
Afatinib
Tucatinib
Tesevatinib
Fostamatinib
Brigatinib
Margetuximab
Zanubrutinib
Diseases
Other well-defined immunodeficiency syndromes, including the following seven diseases: Wiskott-Aldrich syndrome; DiGeorge syndrome; Hyper-IgE syndrome; X-linked lymphoproliferative syndrome; Immunodeficiency, Polyendocrinopathy, Enteropathy, X-linked Syndrome (IPEX); Cartilage-Hair Hypoplasia; Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)
Oral cancer
Choriocarcinoma
Pancreatic cancer
Gastric cancer
Bladder cancer
Endometrial Cancer
Ovarian cancer
Cholangiocarcinoma
Breast cancer
Cervical cancer
GWAS
Apolipoprotein B levels (
32203549
)
Atopic dermatitis (
26482879
)
Autoimmune thyroid disease (
32581359
)
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Composite immunoglobulin trait (IgA/IgG) (
28628107
)
Crohn's disease (
18587394
28067908
21102463
23266558
)
Crohn's disease or systemic sclerosis (
32024964
)
Diastolic blood pressure (
30578418
)
Inflammatory bowel disease (
27569725
28067908
26278503
23128233
)
Itch intensity from mosquito bite (
28199695
)
Itch intensity from mosquito bite adjusted by bite size (
28199695
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
27863252
)
Mean spheric corpuscular volume (
32888494
)
Multiple sclerosis (
31604244
22190364
24076602
21833088
20159113
)
Psoriasis (
25903422
23143594
)
Systemic lupus erythematosus (
28714469
)
Type 2 diabetes (
30054458
)
Ulcerative colitis (
28067908
)
Adult asthma (
30787307
)
Asthma (
31619474
29273806
)
Asthma or allergic disease (pleiotropy) (
29785011
)
Bipolar disorder (
27329760
)
Estimated glomerular filtration rate (
31451708
)
Pancreatic ductal adenocarcinoma (
30541042
)
Polycystic ovary syndrome (
26416764
)
Refractive error (
32231278
)
Systemic lupus erythematosus (
26502338
28714469
)
Ulcerative colitis (
20228799
)
Interacting Genes
208 interacting genes:
ABL2
ADRB2
AMBP
AR
ARFIP2
ASXL1
ATF3
BATF3
BCKDK
BHLHE40
BICD1
BLK
BMX
BRCA1
BRWD1
CA8
CAPN1
CAPNS1
CBL
CCDC87
CCND1
CCR1
CCR5
CDK9
CDKN1A
CEP120
CHTF18
CNDP2
CORO1A
CREBBP
CSF2RB
CSF3R
CXCR4
DAXX
DOK2
DOK3
DTNA
ECH1
EGFR
EIF2AK2
ELP2
EP300
EPHA3
ERBB2
ERBIN
ESR1
FAM117B
FBXW7
FER
FES
FGFR3
FGFR4
FGR
FHL2
FLT1
FOXM1
FYN
GATA1
GATA2
GHR
GNL3
GSTCD
GTF2I
HCK
HDAC1
HDAC2
HDAC3
HES1
HES5
HESX1
HIF1A
HIVEP1
HLA-A
HNF1A
HNRNPM
HOXC11
HSP90AA1
HSP90AB1
IFNAR1
IFNAR2
IGF1R
IL1RAP
IL22RA1
IL23R
IL2RA
IL2RB
IL6R
IL6ST
IL7R
IMPDH2
IRAK1
JAK1
JAK2
JAK3
JUN
KAT5
KDM1A
KHDRBS1
KLF15
KPNA1
KPNA6
KRTAP10-7
LAMB2
LASP1
LCK
LEPR
LMO2
LYN
MAP3K13
MAP3K7
MAPK1
MAPK3
MAPK8
MAPKAPK2
MEG3
MET
MNDA
MORC4
MPZL1
MRPS31
MTOR
MYOD1
NACAD
NCOA1
NDUFA13
NFKB1
NFKBIZ
NIF3L1
NLK
NMI
NR3C1
NR4A1
NUFIP2
NXT2
OFCC1
OGDHL
PAFAH1B2
PAQR7
PCBD2
PDGFRA
PDGFRB
PDIA3
PELP1
PIAS3
PIK3R1
PIK3R2
PIK3R3
PINK1
PML
POM121
PPARD
PRKCD
PTK2B
PTMA
PTPN1
PTPN11
PTPN2
RABGAP1
RAC1
RACK1
RB1
RELA
RET
RPA2
RPL11
RPS6KA5
RPS9
RRAD
SCAF11
SETD7
SH2D2A
SH3BP2
SIAH2
SIN3A
SMARCA4
SPRY1
SRC
SRI
SRRT
SS18L1
STAP2
STAT1
STAT4
STAT5A
STAT5B
STAT6
STMN1
SULT2A1
SUMO4
SUPT20H
SYK
TASOR2
TDG
TM4SF19
TRIM28
TRIP10
TSHR
TSLP
TWIST1
VPS39
WDFY3
ZFPM2
ZNF148
ZNF281
ZNF467
ZNF557
ZNF829
ZNRD2
350 interacting genes:
AATK
ABCB5
ABL1
ABL2
ACP1
ACP3
ADGRB1
AIP
AKAP12
AKT1
ALDOA
ALDOC
ALK
ANKS1A
ANKS1B
ANXA6
AP3B2
APBB1
APBB3
APLP1
ARF1
ARF5
ARNT
ASRGL1
ATP6AP1
ATP6V0C
AURKA
BAAT
BCAR3
BECN1
BLK
BLNK
BMX
BNIP1
BTC
CACYBP
CALM1
CAV1
CBLC
CBR1
CCDC180
CCND2
CCT3
CD44
CD82
CDK4
CDK6
CDK8
CDKN2B
CDKN2C
CEND1
CFAP298
CFL1
CHN1
CISH
CKB
CLASP2
CLCN6
CLNK
COL9A2
COL9A3
CRIP2
CRK
CRKL
CSDE1
CTNNB1
CXCL8
CYLC2
CYP17A1
DAB1
DDR1
DLG4
DOK1
DOK4
DOK6
DST
DUSP14
DUSP18
DUSP19
EGF
EGFR
EPHA1
EPHA2
EPHA3
EPHA4
EPHA5
EPHB1
EPHB2
EPHB3
EPHB6
ERBB3
ERBB4
ERBIN
ERG28
ERRFI1
ESR1
FAM241B
FBP1
FBXO7
FER
FES
FGFR1
FGFR2
FGFR3
FGFR4
FGR
FKBP1A
FKBP3
FKBP8
FLNB
FLT3
FLT4
FRAT2
FZR1
GAB1
GABARAPL1
GABARAPL2
GAPDH
GLCE
GLIS2
GLRX3
GMPR2
GPM6B
GRAP2
GRB10
GRB14
GRB2
GRB7
GRK2
GRM1
GSN
HCK
HDAC6
HDLBP
HGF
HLA-A
HRAS
HSD17B3
HSH2D
HSP90AA1
HSP90B1
HSPA1A
HSPA5
HSPA9
HSPD1
IARS1
IGF1R
IL13RA2
IL6ST
ILF3
ILKAP
INPPL1
INSR
INSRR
IRF2BP2
IRS1
IRS4
ITGA5
ITGB4
ITK
ITPKA
ITPR1
JAK1
JAK2
JMJD4
JUP
KCTD6
KDELR2
KLC1
KLK5
LATS2
LCK
LCP2
LGALS8
LPCAT4
LRRC7
LYN
LYPD3
MAP2K1
MAP2K3
MAP2K5
MAPK8IP1
MAPK8IP2
MATK
MDH1
MEPCE
MERTK
MET
MSN
MST1R
MTCH1
MUC1
MUC4
MUCL1
MYC
MYO9A
NAT2
NCK1
NCK2
NEFH
NF2
NINL
NRG1
NTRK1
NTRK2
NTRK3
NUDT16L1
ODF2L
PABPC1
PAK1
PDCD11
PDGFRA
PDGFRB
PEBP1
PGAM1
PHF23
PICK1
PIK3C2A
PIK3C2B
PIK3R1
PIK3R2
PIK3R3
PIN4
PLCG1
PLCG2
POLD2
POU6F1
PPA1
PPM1A
PPM1F
PRDM14
PRDX5
PSAP
PSMA1
PSMC3
PSMC3IP
PSMD3
PTGES3L-AARSD1
PTK2
PTK2B
PTK6
PTK7
PTPN11
PTPN18
PTPN6
PTPRR
PTPRT
PTPRU
RAB5C
RAF1
RASA1
RASSF1
RBM15B
RET
RHBDD2
RHOBTB2
RIN1
RIN2
ROR2
RPRML
RTN4
S100A11
SAFB2
SELENOK
SERPINA3
SFRP4
SH2B1
SH2B2
SH2B3
SH2D1A
SH2D1B
SH2D2A
SH2D3A
SH2D3C
SH2D5
SH3BGRL3
SH3BP2
SHB
SHC1
SHC2
SHC3
SHC4
SHD
SLA
SLA2
SLC7A4
SMAD1
SMIM20
SMPD4
SNAP91
SOCS1
SOCS3
SOCS5
SOCS6
SOS1
SPP1
SRC
SRPK1
STAP1
STAT3
STIP1
STK11
STK24
STMN1
STMN2
STUB1
STYK1
STYX
SUPT6H
SYK
SYNM
TCEAL2
TEC
TGFA
TGFB1
THRSP
TLN1
TMA7
TMEM134
TMEM230
TNS1
TNS2
TNS3
TOB1
TP53
TRIP6
TRMO
TSEN15
TTC9B
TTYH2
TVP23B
TXK
TXN
TYMP
TYRO3
UBB
USP2
UTP18
VAPA
VAV1
VAV2
VAV3
YES1
YWHAZ
ZAP70
ZFAND1
ZMAT2
ZMYND8
ZNF189
ZNF532
Entrez ID
6774
2064
HPRD ID
00026
01281
Ensembl ID
ENSG00000168610
ENSG00000141736
Uniprot IDs
P40763
F5H1T4
J3QLU9
P04626
X5DNK3
PDB IDs
5AX3
5U5S
6NJS
6NUQ
6QHD
6TLC
1MFG
1MFL
1MW4
1N8Z
1OVC
1QR1
1S78
2A91
2JWA
2KS1
2L4K
2N2A
3BE1
3H3B
3MZW
3N85
3PP0
3RCD
3WLW
3WSQ
4GFU
4HRL
4HRM
4HRN
5K33
5KWG
5MY6
5O4G
5OB4
5TQS
6ATT
6BGT
6J71
6OGE
Enriched GO Terms of Interacting Partners
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