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TBP and HTT
Data Source:
HPRD
(in vitro)
TBP
HTT
Description
TATA-box binding protein
huntingtin
Image
GO Annotations
Cellular Component
Chromatin
Euchromatin
Female Pronucleus
Male Pronucleus
Nucleus
Nucleoplasm
Transcription Factor TFIID Complex
Transcription Factor TFIIA Complex
Cytoplasm
Protein-containing Complex
Transcription Preinitiation Complex
Nucleus
Nucleoplasm
Cytoplasm
Early Endosome
Late Endosome
Autophagosome
Endoplasmic Reticulum
Golgi Apparatus
Centriole
Cytosol
Inclusion Body
Axon
Dendrite
Cytoplasmic Vesicle Membrane
Protein-containing Complex
Perinuclear Region Of Cytoplasm
Presynaptic Cytosol
Postsynaptic Cytosol
Molecular Function
Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Core Promoter Sequence-specific DNA Binding
RNA Polymerase III General Transcription Initiation Factor Activity
Core Promoter Sequence-specific DNA Binding
RNA Polymerase II General Transcription Initiation Factor Binding
TFIIB-class Transcription Factor Binding
RNA Polymerase II Repressing Transcription Factor Binding
Protein Binding
Transcription Factor Binding
RNA Polymerase II General Transcription Initiation Factor Activity
Aryl Hydrocarbon Receptor Binding
Enzyme Binding
Repressing Transcription Factor Binding
General Transcription Initiation Factor Activity
P53 Binding
Protein Binding
Profilin Binding
Kinase Binding
Heat Shock Protein Binding
Dynactin Binding
Identical Protein Binding
Ion Channel Binding
Dynein Intermediate Chain Binding
Beta-tubulin Binding
Biological Process
DNA-templated Transcription, Initiation
Transcription Initiation From RNA Polymerase I Promoter
Transcription Elongation From RNA Polymerase I Promoter
Termination Of RNA Polymerase I Transcription
Transcription By RNA Polymerase II
Transcription Initiation From RNA Polymerase II Promoter
Transcription By RNA Polymerase III
Spermatogenesis
Viral Process
SnRNA Transcription By RNA Polymerase II
Positive Regulation Of Gene Expression, Epigenetic
Positive Regulation Of Transcription, DNA-templated
RNA Polymerase II Preinitiation Complex Assembly
Regulation Of Signal Transduction By P53 Class Mediator
Establishment Of Mitotic Spindle Orientation
Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum
Apoptotic Process
Golgi Organization
Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity
Protein Destabilization
Vocal Learning
Positive Regulation Of Apoptotic Process
Regulation Of Phosphoprotein Phosphatase Activity
Positive Regulation Of Cilium Assembly
Vesicle Transport Along Microtubule
Microtubule-based Transport
Positive Regulation Of Autophagy Of Mitochondrion
Positive Regulation Of Lipophagy
Regulation Of CAMKK-AMPK Signaling Cascade
Positive Regulation Of Aggrephagy
Regulation Of CAMP-dependent Protein Kinase Activity
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways
HIV Transcription Initiation
RNA Polymerase II HIV Promoter Escape
Transcription of the HIV genome
SIRT1 negatively regulates rRNA expression
NoRC negatively regulates rRNA expression
B-WICH complex positively regulates rRNA expression
RNA Polymerase II Pre-transcription Events
Regulation of TP53 Activity through Phosphorylation
RNA polymerase II transcribes snRNA genes
RNA polymerase II transcribes snRNA genes
RNA Polymerase I Transcription Initiation
RNA Polymerase I Transcription Initiation
RNA Polymerase I Promoter Escape
RNA Polymerase II Promoter Escape
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
RNA Polymerase I Transcription Termination
RNA Polymerase III Abortive And Retractive Initiation
RNA Polymerase II Transcription Initiation
RNA Polymerase II Transcription Initiation And Promoter Clearance
RNA Polymerase III Transcription Initiation From Type 1 Promoter
RNA Polymerase III Transcription Initiation From Type 1 Promoter
RNA Polymerase III Transcription Initiation From Type 2 Promoter
RNA Polymerase III Transcription Initiation From Type 2 Promoter
RNA Polymerase III Transcription Initiation From Type 3 Promoter
RNA Polymerase III Transcription Initiation From Type 3 Promoter
Estrogen-dependent gene expression
Regulation of MECP2 expression and activity
Drugs
Copper
Diseases
Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
Huntington's disease (HD)
GWAS
Type 1 diabetes (
21980299
)
Alcohol consumption (
31358974
)
Estimated glomerular filtration rate (
31152163
)
Household income (MTAG) (
31844048
)
Itch intensity from mosquito bite adjusted by bite size (
28199695
)
Mean platelet volume (
32888494
)
Monobrow (
27182965
)
Neutrophil count (
32888494
)
Parental lifespan (
30642433
)
Platelet count (
32888494
)
Serum sulfate level (
27412988
)
Tuberculosis (
29036319
)
Type 2 diabetes (
30297969
)
White blood cell count (
32888494
)
Worry too long after an embarrassing experience (
29500382
)
Worry/vulnerability (special factor of neuroticism) (
30867560
)
Interacting Genes
122 interacting genes:
ABT1
AHR
AR
ATF4
BCL3
BRD2
BRF1
BRF2
BTAF1
CAND2
CITED2
COL26A1
CREG1
CREM
CTBP1
CTCFL
CUEDC2
CXXC1
DHX9
DR1
DRAP1
E2F1
EDF1
ELF3
ESR1
ETS1
FATE1
FOS
FOXF2
GOLGA2
GTF2A1
GTF2A1L
GTF2A2
GTF2B
GTF2E1
GTF2E2
GTF2F1
GTF2F2
GTF2H4
GTF3C2
GTF3C3
GTF3C4
GTF3C5
H3-4
HAP1
HMBOX1
HMGB1
HNF4A
HNRNPK
HSF1
HTT
HUWE1
IKZF1
JUN
JUND
JUP
KDM5A
KLF5
MBD2
MCM2
MDM2
MSX1
MYC
NACA
NCAPH
NCOA1
NCOA3
NCOA6
NFYB
NFYC
NR3C1
PAX3
PAX5
PAX6
PIAS1
PIAS3
POLR2A
POLR3F
POU2F1
POU2F2
POU3F2
PSMC2
PSME3
RB1
REL
RELA
REST
RNF4
RUVBL1
RUVBL2
RXRA
SERPINB5
SNAPC1
SNAPC2
SNAPC4
SP1
SPI1
SPIB
SSX2IP
SUB1
TAF1
TAF10
TAF11
TAF12
TAF13
TAF1A
TAF1B
TAF1C
TAF1L
TAF5
TAF7L
TCF12
TEAD1
TP53
TRAM2
TRIP4
UBE2I
UBTF
WDR62
YEATS2
YWHAE
ZNF76
110 interacting genes:
AKT1
AMFR
AP2A2
BDKRB1
CASP1
CASP3
CASP6
CBS
CEP126
CHD3
CHUK
CREBBP
CRMP1
CTBP1
DLG4
DNALI1
DPPA4
DUSP10
ECH1
EGFR
ELP1
ERCC6L
ETV4
EVL
F8A1
FEZ1
FICD
FTL
GAPDH
GGA2
GIT1
GOLPH3L
GPRASP2
GRB2
H2AP
H3C10
HAP1
HEYL
HIP1
HIP1R
HOXC11
HOXC4
HSP90AA1
HSPA8
HYPK
IFT20
IKBKB
ING5
KAT2B
MAGEA3
MAGEB18
MAGEB6
MAP3K10
MBD1
MED21
MED31
MID1
MRFAP1
MRFAP1L1
MTSS1
NCOR1
NUP58
OPTN
OSTF1
PACSIN1
PDK2
PEX11B
PFN2
PIAS1
PIAS4
PIK3R1
PML
PPP2CA
PRPF40A
PRPF40B
PSMC5
RASA1
REST
RHEB
RNF20
RPS6KB1
SAP30
SETD2
SH3GL3
SH3GLB1
SIN3A
SP1
SUMO1
SYMPK
TACC1
TAF4
TBP
TCERG1
TGM2
TP53
TPR
TRAFD1
TRIP10
TTC23
TUBB
UBAC1
UBE2E3
UBE2K
UTP14A
VCP
XRCC6
ZDHHC17
ZFYVE19
ZNF451
ZNF655
Entrez ID
6908
3064
HPRD ID
02511
00883
Ensembl ID
ENSG00000112592
ENSG00000197386
Uniprot IDs
P20226
Q32MN7
P42858
PDB IDs
1C9B
1CDW
1JFI
1NVP
1TGH
4ROC
4ROD
4ROE
5FUR
5IY6
5IY7
5IY8
5IY9
5IYA
5IYB
5IYC
5IYD
5N9G
6MZD
6MZL
6MZM
6O9L
2D3X
2LD0
2LD2
3IO4
3IO6
3IOR
3IOT
3IOU
3IOV
3IOW
3LRH
4FE8
4FEB
4FEC
4FED
4RAV
6EZ8
6N8C
6RMH
6X9O
Enriched GO Terms of Interacting Partners
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