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TBP and GTF2B
Data Source:
BioGRID
(x-ray crystallography, pull down, x-ray crystallography, x-ray crystallography, pull down)
HPRD
(in vitro, in vivo)
TBP
GTF2B
Description
TATA-box binding protein
general transcription factor IIB
Image
GO Annotations
Cellular Component
Chromatin
Euchromatin
Female Pronucleus
Male Pronucleus
Nucleus
Nucleoplasm
Transcription Factor TFIID Complex
Transcription Factor TFIIA Complex
Cytoplasm
Protein-containing Complex
Transcription Preinitiation Complex
Nucleus
Nucleoplasm
Transcription Factor TFIID Complex
Chromosome
Nuclear Body
Protein-DNA Complex
RNA Polymerase II Transcription Regulator Complex
Transcription Preinitiation Complex
Molecular Function
Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Core Promoter Sequence-specific DNA Binding
RNA Polymerase III General Transcription Initiation Factor Activity
Core Promoter Sequence-specific DNA Binding
RNA Polymerase II General Transcription Initiation Factor Binding
TFIIB-class Transcription Factor Binding
RNA Polymerase II Repressing Transcription Factor Binding
Protein Binding
Transcription Factor Binding
RNA Polymerase II General Transcription Initiation Factor Activity
Aryl Hydrocarbon Receptor Binding
Enzyme Binding
Repressing Transcription Factor Binding
General Transcription Initiation Factor Activity
RNA Polymerase II Core Promoter Sequence-specific DNA Binding
RNA Polymerase II Complex Binding
Histone Acetyltransferase Activity
Protein Binding
Transcription Factor Binding
Zinc Ion Binding
RNA Polymerase II General Transcription Initiation Factor Activity
Acetyltransferase Activity
TBP-class Protein Binding
Thyroid Hormone Receptor Binding
Promoter-specific Chromatin Binding
Biological Process
DNA-templated Transcription, Initiation
Transcription Initiation From RNA Polymerase I Promoter
Transcription Elongation From RNA Polymerase I Promoter
Termination Of RNA Polymerase I Transcription
Transcription By RNA Polymerase II
Transcription Initiation From RNA Polymerase II Promoter
Transcription By RNA Polymerase III
Spermatogenesis
Viral Process
SnRNA Transcription By RNA Polymerase II
Positive Regulation Of Gene Expression, Epigenetic
Positive Regulation Of Transcription, DNA-templated
RNA Polymerase II Preinitiation Complex Assembly
Regulation Of Signal Transduction By P53 Class Mediator
Transcriptional Start Site Selection At RNA Polymerase II Promoter
DNA-templated Transcription, Initiation
Transcription By RNA Polymerase II
Transcription Initiation From RNA Polymerase II Promoter
Protein Acetylation
Histone Acetylation
Viral Transcription
SnRNA Transcription By RNA Polymerase II
RNA Polymerase II Preinitiation Complex Assembly
Positive Regulation Of Core Promoter Binding
RNA Polymerase II Core Complex Assembly
Pathways
HIV Transcription Initiation
RNA Polymerase II HIV Promoter Escape
Transcription of the HIV genome
SIRT1 negatively regulates rRNA expression
NoRC negatively regulates rRNA expression
B-WICH complex positively regulates rRNA expression
RNA Polymerase II Pre-transcription Events
Regulation of TP53 Activity through Phosphorylation
RNA polymerase II transcribes snRNA genes
RNA polymerase II transcribes snRNA genes
RNA Polymerase I Transcription Initiation
RNA Polymerase I Transcription Initiation
RNA Polymerase I Promoter Escape
RNA Polymerase II Promoter Escape
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
RNA Polymerase I Transcription Termination
RNA Polymerase III Abortive And Retractive Initiation
RNA Polymerase II Transcription Initiation
RNA Polymerase II Transcription Initiation And Promoter Clearance
RNA Polymerase III Transcription Initiation From Type 1 Promoter
RNA Polymerase III Transcription Initiation From Type 1 Promoter
RNA Polymerase III Transcription Initiation From Type 2 Promoter
RNA Polymerase III Transcription Initiation From Type 2 Promoter
RNA Polymerase III Transcription Initiation From Type 3 Promoter
RNA Polymerase III Transcription Initiation From Type 3 Promoter
Estrogen-dependent gene expression
HIV Transcription Initiation
RNA Polymerase II HIV Promoter Escape
Transcription of the HIV genome
RNA Polymerase II Pre-transcription Events
RNA polymerase II transcribes snRNA genes
RNA polymerase II transcribes snRNA genes
RNA Polymerase II Promoter Escape
RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
RNA Polymerase II Transcription Initiation
RNA Polymerase II Transcription Initiation And Promoter Clearance
Drugs
Diseases
Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
GWAS
Type 1 diabetes (
21980299
)
Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) (
30940143
)
Hematocrit (
32888494
)
Intraocular pressure (
29617998
)
Obesity-related traits (
23251661
)
Pulse pressure (
30578418
)
Rosacea symptom severity (
29771307
)
Systolic blood pressure (
28135244
30578418
)
Interacting Genes
122 interacting genes:
ABT1
AHR
AR
ATF4
BCL3
BRD2
BRF1
BRF2
BTAF1
CAND2
CITED2
COL26A1
CREG1
CREM
CTBP1
CTCFL
CUEDC2
CXXC1
DHX9
DR1
DRAP1
E2F1
EDF1
ELF3
ESR1
ETS1
FATE1
FOS
FOXF2
GOLGA2
GTF2A1
GTF2A1L
GTF2A2
GTF2B
GTF2E1
GTF2E2
GTF2F1
GTF2F2
GTF2H4
GTF3C2
GTF3C3
GTF3C4
GTF3C5
H3-4
HAP1
HMBOX1
HMGB1
HNF4A
HNRNPK
HSF1
HTT
HUWE1
IKZF1
JUN
JUND
JUP
KDM5A
KLF5
MBD2
MCM2
MDM2
MSX1
MYC
NACA
NCAPH
NCOA1
NCOA3
NCOA6
NFYB
NFYC
NR3C1
PAX3
PAX5
PAX6
PIAS1
PIAS3
POLR2A
POLR3F
POU2F1
POU2F2
POU3F2
PSMC2
PSME3
RB1
REL
RELA
REST
RNF4
RUVBL1
RUVBL2
RXRA
SERPINB5
SNAPC1
SNAPC2
SNAPC4
SP1
SPI1
SPIB
SSX2IP
SUB1
TAF1
TAF10
TAF11
TAF12
TAF13
TAF1A
TAF1B
TAF1C
TAF1L
TAF5
TAF7L
TCF12
TEAD1
TP53
TRAM2
TRIP4
UBE2I
UBTF
WDR62
YEATS2
YWHAE
ZNF76
57 interacting genes:
ADRB2
ATF4
BCL3
CIITA
CREBBP
CTBP1
DEPDC7
DHX9
DRAP1
EP300
ESR1
ESRRA
FBXO25
FOXF2
GOLGA6L9
GTF2E1
GTF2E2
GTF2F1
GTF2F2
GTF2H4
HMGCL
HNF4A
HSF1
IKZF1
JAK3
JUN
KLF5
MCM2
MECP2
NCOA1
NCOA3
NCOA4
NCOR1
NOLC1
NR1D2
NR2F1
NR5A1
POLR2A
POLR2E
POU3F2
PSMC2
PSMC5
REL
RELA
REST
SLC22A2
SRA1
TAF11
TAF9
TBP
TBPL1
TCEA2
THRA
TNIP1
TRAM2
VDR
YWHAE
Entrez ID
6908
2959
HPRD ID
02511
08928
Ensembl ID
ENSG00000112592
ENSG00000137947
Uniprot IDs
P20226
Q32MN7
Q00403
PDB IDs
1C9B
1CDW
1JFI
1NVP
1TGH
4ROC
4ROD
4ROE
5FUR
5IY6
5IY7
5IY8
5IY9
5IYA
5IYB
5IYC
5IYD
5N9G
6MZD
6MZL
6MZM
6O9L
1C9B
1DL6
1RLY
1RO4
1TFB
1VOL
2PHG
5IY6
5IY7
5IY8
5IY9
5IYA
5IYB
5IYC
5IYD
5WH1
6O9L
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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