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HTT and TPR
Data Source:
HPRD
(in vitro, in vivo, two hybrid)
HTT
TPR
Description
huntingtin
translocated promoter region, nuclear basket protein
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Early Endosome
Late Endosome
Autophagosome
Endoplasmic Reticulum
Golgi Apparatus
Centriole
Cytosol
Inclusion Body
Axon
Dendrite
Cytoplasmic Vesicle Membrane
Protein-containing Complex
Perinuclear Region Of Cytoplasm
Presynaptic Cytosol
Postsynaptic Cytosol
Kinetochore
Nucleus
Nuclear Envelope
Nuclear Pore
Nucleoplasm
Cytoplasm
Cytoplasmic Dynein Complex
Extrinsic Component Of Membrane
Nuclear Membrane
Nuclear Periphery
Nuclear Inclusion Body
Host Cell
Nuclear Pore Nuclear Basket
Mitotic Spindle
Molecular Function
P53 Binding
Protein Binding
Profilin Binding
Kinase Binding
Heat Shock Protein Binding
Dynactin Binding
Identical Protein Binding
Ion Channel Binding
Dynein Intermediate Chain Binding
Beta-tubulin Binding
Chromatin Binding
RNA Binding
MRNA Binding
Protein Binding
Tubulin Binding
Structural Constituent Of Nuclear Pore
Heat Shock Protein Binding
Protein Homodimerization Activity
Protein-membrane Adaptor Activity
Mitogen-activated Protein Kinase Binding
Dynein Complex Binding
Biological Process
Establishment Of Mitotic Spindle Orientation
Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum
Apoptotic Process
Golgi Organization
Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity
Protein Destabilization
Vocal Learning
Positive Regulation Of Apoptotic Process
Regulation Of Phosphoprotein Phosphatase Activity
Positive Regulation Of Cilium Assembly
Vesicle Transport Along Microtubule
Microtubule-based Transport
Positive Regulation Of Autophagy Of Mitochondrion
Positive Regulation Of Lipophagy
Regulation Of CAMKK-AMPK Signaling Cascade
Positive Regulation Of Aggrephagy
Regulation Of CAMP-dependent Protein Kinase Activity
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Glycolytic Process
RNA Import Into Nucleus
RNA Export From Nucleus
MRNA Export From Nucleus
TRNA Export From Nucleus
Protein Import Into Nucleus
Protein Export From Nucleus
Nuclear Pore Organization
Mitotic Spindle Assembly Checkpoint
Regulation Of MRNA Export From Nucleus
Regulation Of Mitotic Sister Chromatid Separation
Viral Process
Protein Sumoylation
Viral Transcription
Positive Regulation Of Heterochromatin Assembly
Regulation Of Protein Stability
MRNA Export From Nucleus In Response To Heat Stress
Regulation Of Protein Localization
Cellular Response To Heat
Cellular Response To Interferon-alpha
Regulation Of Protein Import Into Nucleus
Positive Regulation Of Protein Import Into Nucleus
Nuclear Matrix Organization
Negative Regulation Of Translational Initiation
Regulation Of Protein Export From Nucleus
Positive Regulation Of Protein Export From Nucleus
Negative Regulation Of RNA Export From Nucleus
Nuclear Pore Complex Assembly
Cell Division
Regulation Of Gene Silencing By MiRNA
Response To Epidermal Growth Factor
Intracellular Transport Of Virus
Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint
Positive Regulation Of Intracellular Protein Transport
Regulation Of Cellular Response To Heat
Regulation Of Mitotic Spindle Assembly
Pathways
Regulation of MECP2 expression and activity
ISG15 antiviral mechanism
Transport of the SLBP independent Mature mRNA
Transport of the SLBP Dependant Mature mRNA
Transport of Mature mRNA Derived from an Intronless Transcript
Transport of Mature mRNA derived from an Intron-Containing Transcript
Rev-mediated nuclear export of HIV RNA
Transport of Ribonucleoproteins into the Host Nucleus
NS1 Mediated Effects on Host Pathways
Viral Messenger RNA Synthesis
NEP/NS2 Interacts with the Cellular Export Machinery
Regulation of Glucokinase by Glucokinase Regulatory Protein
Nuclear import of Rev protein
Vpr-mediated nuclear import of PICs
snRNP Assembly
SUMOylation of DNA damage response and repair proteins
SUMOylation of ubiquitinylation proteins
Nuclear Pore Complex (NPC) Disassembly
Regulation of HSF1-mediated heat shock response
SUMOylation of SUMOylation proteins
SUMOylation of chromatin organization proteins
SUMOylation of RNA binding proteins
SUMOylation of DNA replication proteins
SUMOylation of DNA replication proteins
Transcriptional regulation by small RNAs
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)
tRNA processing in the nucleus
HCMV Early Events
HCMV Late Events
Drugs
Copper
Diseases
Huntington's disease (HD)
Thyroid cancer
GWAS
Alcohol consumption (
31358974
)
Estimated glomerular filtration rate (
31152163
)
Household income (MTAG) (
31844048
)
Itch intensity from mosquito bite adjusted by bite size (
28199695
)
Mean platelet volume (
32888494
)
Monobrow (
27182965
)
Neutrophil count (
32888494
)
Parental lifespan (
30642433
)
Platelet count (
32888494
)
Serum sulfate level (
27412988
)
Tuberculosis (
29036319
)
Type 2 diabetes (
30297969
)
White blood cell count (
32888494
)
Worry too long after an embarrassing experience (
29500382
)
Worry/vulnerability (special factor of neuroticism) (
30867560
)
Interacting Genes
110 interacting genes:
AKT1
AMFR
AP2A2
BDKRB1
CASP1
CASP3
CASP6
CBS
CEP126
CHD3
CHUK
CREBBP
CRMP1
CTBP1
DLG4
DNALI1
DPPA4
DUSP10
ECH1
EGFR
ELP1
ERCC6L
ETV4
EVL
F8A1
FEZ1
FICD
FTL
GAPDH
GGA2
GIT1
GOLPH3L
GPRASP2
GRB2
H2AP
H3C10
HAP1
HEYL
HIP1
HIP1R
HOXC11
HOXC4
HSP90AA1
HSPA8
HYPK
IFT20
IKBKB
ING5
KAT2B
MAGEA3
MAGEB18
MAGEB6
MAP3K10
MBD1
MED21
MED31
MID1
MRFAP1
MRFAP1L1
MTSS1
NCOR1
NUP58
OPTN
OSTF1
PACSIN1
PDK2
PEX11B
PFN2
PIAS1
PIAS4
PIK3R1
PML
PPP2CA
PRPF40A
PRPF40B
PSMC5
RASA1
REST
RHEB
RNF20
RPS6KB1
SAP30
SETD2
SH3GL3
SH3GLB1
SIN3A
SP1
SUMO1
SYMPK
TACC1
TAF4
TBP
TCERG1
TGM2
TP53
TPR
TRAFD1
TRIP10
TTC23
TUBB
UBAC1
UBE2E3
UBE2K
UTP14A
VCP
XRCC6
ZDHHC17
ZFYVE19
ZNF451
ZNF655
13 interacting genes:
APC
ERCC6
HTT
IFI16
MAD1L1
MAP3K4
MAPK1
MDM2
NUP153
NUP98
SHC1
SUMO2
YWHAQ
Entrez ID
3064
7175
HPRD ID
00883
08927
Ensembl ID
ENSG00000197386
ENSG00000047410
Uniprot IDs
P42858
P12270
PDB IDs
2D3X
2LD0
2LD2
3IO4
3IO6
3IOR
3IOT
3IOU
3IOV
3IOW
3LRH
4FE8
4FEB
4FEC
4FED
4RAV
6EZ8
6N8C
6RMH
6X9O
5TO5
5TO6
5TO7
5TVB
Enriched GO Terms of Interacting Partners
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