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PDGFRB and SHC1
Data Source:
HPRD
(in vivo)
PDGFRB
SHC1
Description
platelet derived growth factor receptor beta
SHC adaptor protein 1
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Golgi Apparatus
Plasma Membrane
Integral Component Of Plasma Membrane
Focal Adhesion
Cell Surface
Membrane
Apical Plasma Membrane
Intrinsic Component Of Plasma Membrane
Cytoplasmic Vesicle
Lysosomal Lumen
Intracellular Membrane-bounded Organelle
Receptor Complex
Mitochondrial Matrix
Cytosol
Plasma Membrane
Shc-EGFR Complex
Molecular Function
Protein Tyrosine Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
Platelet Activating Factor Receptor Activity
Platelet-derived Growth Factor-activated Receptor Activity
Platelet-derived Growth Factor Beta-receptor Activity
Signaling Receptor Binding
Platelet-derived Growth Factor Receptor Binding
Protein Binding
ATP Binding
Growth Factor Binding
Enzyme Binding
Protein Kinase Binding
Vascular Endothelial Growth Factor Binding
Phosphatidylinositol 3-kinase Binding
Platelet-derived Growth Factor Binding
Phosphotyrosine Residue Binding
Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity
Epidermal Growth Factor Receptor Binding
Insulin Receptor Binding
Insulin-like Growth Factor Receptor Binding
Neurotrophin TRKA Receptor Binding
Protein Binding
Phospholipid Binding
Protein Kinase Binding
Receptor Tyrosine Kinase Binding
Ephrin Receptor Binding
Epidermal Growth Factor Binding
Biological Process
MAPK Cascade
Glycosaminoglycan Biosynthetic Process
Signal Transduction
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
G Protein-coupled Receptor Signaling Pathway
Multicellular Organism Development
Aging
Positive Regulation Of Cell Population Proliferation
Male Gonad Development
Response To Toxic Substance
Positive Regulation Of Phospholipase C Activity
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Positive Regulation Of Smooth Muscle Cell Migration
Cell Migration
Peptidyl-tyrosine Phosphorylation
Positive Regulation Of Cell Migration
Response To Estradiol
Positive Regulation Of Phosphoprotein Phosphatase Activity
Response To Retinoic Acid
Regulation Of Actin Cytoskeleton Organization
Positive Regulation Of Collagen Biosynthetic Process
Positive Regulation Of Kinase Activity
Response To Fluid Shear Stress
Positive Regulation Of Rho Protein Signal Transduction
Cell Migration Involved In Vasculogenesis
Metanephric Mesenchymal Cell Migration
Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Aorta Morphogenesis
Cellular Response To Platelet-derived Growth Factor Stimulus
Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway
Wound Healing
Response To Hydrogen Peroxide
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Positive Regulation Of MAP Kinase Activity
Positive Regulation Of Phosphatidylinositol 3-kinase Activity
Response To Estrogen
Positive Regulation Of Mitotic Nuclear Division
Phosphatidylinositol Metabolic Process
Protein Autophosphorylation
Platelet-derived Growth Factor Receptor Signaling Pathway
Phosphatidylinositol-mediated Signaling
Positive Regulation Of Fibroblast Proliferation
Positive Regulation Of Smooth Muscle Cell Proliferation
Inner Ear Development
Positive Regulation Of Chemotaxis
Positive Regulation Of Protein Kinase B Signaling
Cardiac Myofibril Assembly
Response To Hyperoxia
Cell Chemotaxis
Lung Growth
Cell Migration Involved In Coronary Angiogenesis
Retina Vasculature Development In Camera-type Eye
Positive Regulation Of ERK1 And ERK2 Cascade
Smooth Muscle Cell Chemotaxis
Metanephric Mesenchyme Development
Metanephric Glomerular Mesangial Cell Proliferation Involved In Metanephros Development
Metanephric Glomerular Capillary Formation
Metanephric Comma-shaped Body Morphogenesis
Metanephric S-shaped Body Morphogenesis
Positive Regulation Of Calcium Ion Import
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Positive Regulation Of Hepatic Stellate Cell Activation
Positive Regulation Of DNA Biosynthetic Process
MAPK Cascade
Activation Of MAPK Activity
Angiogenesis
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Epidermal Growth Factor Receptor Signaling Pathway
Regulation Of Epidermal Growth Factor-activated Receptor Activity
Ras Protein Signal Transduction
Axon Guidance
Heart Development
Positive Regulation Of Cell Population Proliferation
Insulin Receptor Signaling Pathway
Viral Process
Cytokine-mediated Signaling Pathway
Actin Cytoskeleton Reorganization
Interleukin-15-mediated Signaling Pathway
IRE1-mediated Unfolded Protein Response
Fc-epsilon Receptor Signaling Pathway
Interleukin-2-mediated Signaling Pathway
ERBB2 Signaling Pathway
Regulation Of Growth
Defense Response To Bacterium
Negative Regulation Of Apoptotic Process
Positive Regulation Of MAPK Cascade
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Ras Protein Signal Transduction
Leukocyte Migration
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Growth Factor Stimulus
Cell-cell Adhesion
Pathways
PIP3 activates AKT signaling
Downstream signal transduction
Signaling by PDGF
Constitutive Signaling by Aberrant PI3K in Cancer
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
SHC1 events in ERBB2 signaling
SHC1 events in ERBB2 signaling
SHC1 events in ERBB4 signaling
Signalling to RAS
Signalling to RAS
SHC1 events in EGFR signaling
Tie2 Signaling
Integrin signaling
XBP1(S) activates chaperone genes
Interleukin-3, Interleukin-5 and GM-CSF signaling
Constitutive Signaling by EGFRvIII
RAF/MAP kinase cascade
Signal attenuation
Insulin receptor signalling cascade
Insulin receptor signalling cascade
RET signaling
Interleukin-15 signaling
Interleukin-15 signaling
Interleukin-2 signaling
Erythropoietin activates RAS
Erythropoietin activates RAS
Interleukin receptor SHC signaling
Constitutive Signaling by Overexpressed ERBB2
Signaling by ERBB2 KD Mutants
Signaling by ERBB2 ECD mutants
Signaling by ERBB2 TMD/JMD mutants
Drugs
Becaplermin
Sorafenib
Imatinib
Dasatinib
Sunitinib
XL999
XL820
Pazopanib
Midostaurin
Regorafenib
Nintedanib
Polaprezinc
Trapidil
Foreskin fibroblast (neonatal)
Fostamatinib
Erdafitinib
Pexidartinib
Ripretinib
Pralsetinib
Diseases
Glioma
GWAS
Blood protein levels (
30072576
29875488
28240269
)
Cytokine network levels (multivariate analysis) (
31679650
)
Granulocyte percentage of myeloid white cells (
27863252
)
Inflammatory biomarkers (multivariate analysis) (
33110245
)
Monocyte count (
27863252
)
Monocyte percentage of white cells (
32888494
27863252
)
Bipolar disorder (
31043756
)
Body fat distribution (leg fat ratio) (
30664634
)
Body fat distribution (trunk fat ratio) (
30664634
)
Eosinophil counts (
29403010
)
Hemoglobin levels (
32327693
)
Inflammatory bowel disease (
27569725
)
Prostate cancer (
23535732
)
Interacting Genes
76 interacting genes:
ABL1
ABL2
ARAF
BAG1
CAV1
CAV3
CBL
CEP76
COPA
COPB1
CRK
EGFR
EIF2AK2
ERBB2
FGFR1
FYN
GAB1
GRB10
GRB14
GRB2
GRB7
ITGB3
JAK1
JAK2
KLHL12
KPRP
KRT31
KRT34
KRTAP10-9
KRTAP12-3
KRTAP4-12
NCK1
NCK2
NEDD4
PDAP1
PDGFB
PDGFD
PDGFRA
PIK3C2B
PIK3CA
PIK3R1
PIK3R2
PIK3R3
PLCG1
PPM1L
PRDX2
PTEN
PTK2
PTPN1
PTPN11
PTPN2
PTPN6
PTPRJ
RAF1
RASA1
RPS6KB2
S1PR1
SHC1
SLC9A3R1
SLC9A3R2
SNX1
SNX2
SNX4
SOCS1
SRC
STAT1
STAT3
STAT5A
STAT5B
SYNGAP1
TNK2
TPTE
TRIP6
TYK2
VAV1
YES1
143 interacting genes:
ALK
AP2A1
AP2A2
APP
AR
AXL
BCL3
BCR
BUB1
C11orf58
CALCOCO2
CALD1
CBL
CBLB
CBLC
CD22
CD247
CD3E
CD81
CDH5
CEACAM1
CRK
CRKL
CSF1R
CSF2RB
CSF3R
CSK
DAG1
DDR1
DDR2
DOK1
DUSP23
EGFR
EPHA2
EPOR
EPS8
ERBB2
ERBB3
ERBB4
ESR1
FAM118B
FBXW7
FCGR2A
FCGR3A
FGFR1
FGFR2
FLT1
FLT4
FYN
GAB1
GAB2
GEMIN7
GH1
GHR
GRAP
GRAP2
GRB2
GRB7
HMOX2
IGF1R
IL2
IL2RB
IL2RG
IL4R
IL6ST
ILK
INPP5D
INPPL1
INSR
IRS1
IRS2
ITGB3
ITGB4
JAK2
KDR
KIT
KRT18
LCK
LCP2
LRP1
LTK
LYN
MAP4K1
MAPK1
MAPK14
MAPK6
MAPK8
MAPKAPK2
MET
MME
MPL
MRPL44
MST1R
NGFR
NPM1
NTRK1
NTRK2
NTRK3
NUDT21
OSGEP
PAG1
PAK1
PDGFRB
PIK3C2B
PIK3R1
PIK3R2
PLCG1
PLCG2
PLPP3
PLSCR1
PPP2R5A
PRKCA
PRKCD
PRKRA
PTK2
PTK2B
PTPN11
PTPN12
PTPN2
PTPN6
RAPGEF1
RASA1
RB1
RET
SH2B2
SHCBP1
SMAD4
SOS1
SOS2
SP1
SRC
STAT5A
STAT5B
SUV39H2
SYK
TEC
TEK
TPR
TRIM15
UBASH3B
VAV1
VAV3
ZAP70
Entrez ID
5159
6464
HPRD ID
01423
02780
Ensembl ID
ENSG00000113721
ENSG00000160691
Uniprot IDs
P09619
Q59F04
P29353
PDB IDs
1GQ5
1H9O
1LWP
1SHA
2IUI
2L6W
2PLD
2PLE
3MJG
1MIL
1N3H
1OY2
1QG1
1SHC
1TCE
1WCP
2L1C
4JMH
4XWX
5CZI
6DM4
Enriched GO Terms of Interacting Partners
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