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PDGFRB and PIK3R2
Data Source:
HPRD
(in vivo)
PDGFRB
PIK3R2
Description
platelet derived growth factor receptor beta
phosphoinositide-3-kinase regulatory subunit 2
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Golgi Apparatus
Plasma Membrane
Integral Component Of Plasma Membrane
Focal Adhesion
Cell Surface
Membrane
Apical Plasma Membrane
Intrinsic Component Of Plasma Membrane
Cytoplasmic Vesicle
Lysosomal Lumen
Intracellular Membrane-bounded Organelle
Receptor Complex
Nucleus
Cytosol
Phosphatidylinositol 3-kinase Complex
Molecular Function
Protein Tyrosine Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
Platelet Activating Factor Receptor Activity
Platelet-derived Growth Factor-activated Receptor Activity
Platelet-derived Growth Factor Beta-receptor Activity
Signaling Receptor Binding
Platelet-derived Growth Factor Receptor Binding
Protein Binding
ATP Binding
Growth Factor Binding
Enzyme Binding
Protein Kinase Binding
Vascular Endothelial Growth Factor Binding
Phosphatidylinositol 3-kinase Binding
Platelet-derived Growth Factor Binding
Phosphotyrosine Residue Binding
Protein Binding
Protein Phosphatase Binding
Receptor Tyrosine Kinase Binding
1-phosphatidylinositol-3-kinase Regulator Activity
Protein Heterodimerization Activity
Biological Process
MAPK Cascade
Glycosaminoglycan Biosynthetic Process
Signal Transduction
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
G Protein-coupled Receptor Signaling Pathway
Multicellular Organism Development
Aging
Positive Regulation Of Cell Population Proliferation
Male Gonad Development
Response To Toxic Substance
Positive Regulation Of Phospholipase C Activity
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Positive Regulation Of Smooth Muscle Cell Migration
Cell Migration
Peptidyl-tyrosine Phosphorylation
Positive Regulation Of Cell Migration
Response To Estradiol
Positive Regulation Of Phosphoprotein Phosphatase Activity
Response To Retinoic Acid
Regulation Of Actin Cytoskeleton Organization
Positive Regulation Of Collagen Biosynthetic Process
Positive Regulation Of Kinase Activity
Response To Fluid Shear Stress
Positive Regulation Of Rho Protein Signal Transduction
Cell Migration Involved In Vasculogenesis
Metanephric Mesenchymal Cell Migration
Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Aorta Morphogenesis
Cellular Response To Platelet-derived Growth Factor Stimulus
Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway
Wound Healing
Response To Hydrogen Peroxide
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Positive Regulation Of MAP Kinase Activity
Positive Regulation Of Phosphatidylinositol 3-kinase Activity
Response To Estrogen
Positive Regulation Of Mitotic Nuclear Division
Phosphatidylinositol Metabolic Process
Protein Autophosphorylation
Platelet-derived Growth Factor Receptor Signaling Pathway
Phosphatidylinositol-mediated Signaling
Positive Regulation Of Fibroblast Proliferation
Positive Regulation Of Smooth Muscle Cell Proliferation
Inner Ear Development
Positive Regulation Of Chemotaxis
Positive Regulation Of Protein Kinase B Signaling
Cardiac Myofibril Assembly
Response To Hyperoxia
Cell Chemotaxis
Lung Growth
Cell Migration Involved In Coronary Angiogenesis
Retina Vasculature Development In Camera-type Eye
Positive Regulation Of ERK1 And ERK2 Cascade
Smooth Muscle Cell Chemotaxis
Metanephric Mesenchyme Development
Metanephric Glomerular Mesangial Cell Proliferation Involved In Metanephros Development
Metanephric Glomerular Capillary Formation
Metanephric Comma-shaped Body Morphogenesis
Metanephric S-shaped Body Morphogenesis
Positive Regulation Of Calcium Ion Import
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Positive Regulation Of Hepatic Stellate Cell Activation
Positive Regulation Of DNA Biosynthetic Process
Cellular Glucose Homeostasis
Phosphatidylinositol Biosynthetic Process
Insulin Receptor Signaling Pathway
Regulation Of Autophagy
Phosphatidylinositol 3-kinase Signaling
Protein Transport
Cellular Response To Insulin Stimulus
Response To Endoplasmic Reticulum Stress
Fc-epsilon Receptor Signaling Pathway
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Positive Regulation Of Protein Import Into Nucleus
Negative Regulation Of MAPK Cascade
Regulation Of Phosphatidylinositol 3-kinase Activity
Positive Regulation Of Transcription By RNA Polymerase II
Phosphatidylinositol Phosphorylation
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Phosphatidylinositol-mediated Signaling
T Cell Receptor Signaling Pathway
Leukocyte Migration
Regulation Of Small GTPase Mediated Signal Transduction
Positive Regulation Of Protein Kinase B Signaling
Pathways
PIP3 activates AKT signaling
Downstream signal transduction
Signaling by PDGF
Constitutive Signaling by Aberrant PI3K in Cancer
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
PI3K Cascade
IRS-mediated signalling
GPVI-mediated activation cascade
PIP3 activates AKT signaling
Interleukin-7 signaling
Interleukin-7 signaling
Signaling by SCF-KIT
Synthesis of PIPs at the plasma membrane
Downstream signal transduction
Rho GTPase cycle
PI3K/AKT activation
Downstream TCR signaling
Role of phospholipids in phagocytosis
Tie2 Signaling
Constitutive Signaling by Aberrant PI3K in Cancer
DAP12 signaling
Role of LAT2/NTAL/LAB on calcium mobilization
Nephrin family interactions
Costimulation by the CD28 family
CD28 dependent PI3K/Akt signaling
G alpha (q) signalling events
VEGFA-VEGFR2 Pathway
VEGFA-VEGFR2 Pathway
Interleukin-3, Interleukin-5 and GM-CSF signaling
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
RET signaling
Extra-nuclear estrogen signaling
Interleukin receptor SHC signaling
Regulation of signaling by CBL
Regulation of signaling by CBL
Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants
Signaling by PDGFRA extracellular domain mutants
Drugs
Becaplermin
Sorafenib
Imatinib
Dasatinib
Sunitinib
XL999
XL820
Pazopanib
Midostaurin
Regorafenib
Nintedanib
Polaprezinc
Trapidil
Foreskin fibroblast (neonatal)
Fostamatinib
Erdafitinib
Pexidartinib
Ripretinib
Pralsetinib
Isoprenaline
SF1126
Diseases
Glioma
GWAS
Blood protein levels (
30072576
29875488
28240269
)
Cytokine network levels (multivariate analysis) (
31679650
)
Granulocyte percentage of myeloid white cells (
27863252
)
Inflammatory biomarkers (multivariate analysis) (
33110245
)
Monocyte count (
27863252
)
Monocyte percentage of white cells (
32888494
27863252
)
Basophil count (
32888494
)
Basophil percentage of white cells (
32888494
)
Mental health study participation (completed survey) (
31263887
)
Interacting Genes
76 interacting genes:
ABL1
ABL2
ARAF
BAG1
CAV1
CAV3
CBL
CEP76
COPA
COPB1
CRK
EGFR
EIF2AK2
ERBB2
FGFR1
FYN
GAB1
GRB10
GRB14
GRB2
GRB7
ITGB3
JAK1
JAK2
KLHL12
KPRP
KRT31
KRT34
KRTAP10-9
KRTAP12-3
KRTAP4-12
NCK1
NCK2
NEDD4
PDAP1
PDGFB
PDGFD
PDGFRA
PIK3C2B
PIK3CA
PIK3R1
PIK3R2
PIK3R3
PLCG1
PPM1L
PRDX2
PTEN
PTK2
PTPN1
PTPN11
PTPN2
PTPN6
PTPRJ
RAF1
RASA1
RPS6KB2
S1PR1
SHC1
SLC9A3R1
SLC9A3R2
SNX1
SNX2
SNX4
SOCS1
SRC
STAT1
STAT3
STAT5A
STAT5B
SYNGAP1
TNK2
TPTE
TRIP6
TYK2
VAV1
YES1
59 interacting genes:
APP
APPL1
AR
ARRB1
AXL
CBL
CD28
CRK
CRKL
CSF1R
DYDC1
EGF
EGFR
ENKUR
EPHA2
ERBB2
ERBB3
ERBB4
FBXL2
FGFR1
FYN
GAB1
GHR
GOLGA2
GRB2
GRN
HCK
IGF1R
IKZF3
IRS1
IRS2
KIT
KRAS
KRT15
KRT20
KRT38
LAMB2
LMNA
LTBP3
MET
MRFAP1L1
PDGFRB
PIK3CD
RINT1
SEPTIN2
SHC1
SOCS1
SOCS6
SOCS7
SOS1
STAB1
STAT3
SYK
TEC
TGFBR1
TGFBR2
TRIM23
WASF3
YWHAB
Entrez ID
5159
5296
HPRD ID
01423
04404
Ensembl ID
ENSG00000113721
ENSG00000105647
Uniprot IDs
P09619
Q59F04
O00459
PDB IDs
1GQ5
1H9O
1LWP
1SHA
2IUI
2L6W
2PLD
2PLE
3MJG
2KT1
2XS6
3MTT
3O5Z
6OX7
6U28
Enriched GO Terms of Interacting Partners
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