PDGFRB and STAT5A

Data Source:
BioGRID (imaging technique)
HPRD (in vitro)

		PDGFRB	STAT5A
Description		platelet derived growth factor receptor beta	signal transducer and activator of transcription 5A
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Cell Surface Membrane Apical Plasma Membrane Intrinsic Component Of Plasma Membrane Cytoplasmic Vesicle Lysosomal Lumen Intracellular Membrane-bounded Organelle Receptor Complex	Chromatin Nucleoplasm Cytosol
	Molecular Function	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Platelet Activating Factor Receptor Activity Platelet-derived Growth Factor-activated Receptor Activity Platelet-derived Growth Factor Beta-receptor Activity Signaling Receptor Binding Platelet-derived Growth Factor Receptor Binding Protein Binding ATP Binding Growth Factor Binding Enzyme Binding Protein Kinase Binding Vascular Endothelial Growth Factor Binding Phosphatidylinositol 3-kinase Binding Platelet-derived Growth Factor Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding
	Biological Process	MAPK Cascade Glycosaminoglycan Biosynthetic Process Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway G Protein-coupled Receptor Signaling Pathway Multicellular Organism Development Aging Positive Regulation Of Cell Population Proliferation Male Gonad Development Response To Toxic Substance Positive Regulation Of Phospholipase C Activity Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Positive Regulation Of Smooth Muscle Cell Migration Cell Migration Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cell Migration Response To Estradiol Positive Regulation Of Phosphoprotein Phosphatase Activity Response To Retinoic Acid Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Collagen Biosynthetic Process Positive Regulation Of Kinase Activity Response To Fluid Shear Stress Positive Regulation Of Rho Protein Signal Transduction Cell Migration Involved In Vasculogenesis Metanephric Mesenchymal Cell Migration Platelet-derived Growth Factor Receptor-beta Signaling Pathway Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway Aorta Morphogenesis Cellular Response To Platelet-derived Growth Factor Stimulus Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway Wound Healing Response To Hydrogen Peroxide Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of MAP Kinase Activity Positive Regulation Of Phosphatidylinositol 3-kinase Activity Response To Estrogen Positive Regulation Of Mitotic Nuclear Division Phosphatidylinositol Metabolic Process Protein Autophosphorylation Platelet-derived Growth Factor Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Smooth Muscle Cell Proliferation Inner Ear Development Positive Regulation Of Chemotaxis Positive Regulation Of Protein Kinase B Signaling Cardiac Myofibril Assembly Response To Hyperoxia Cell Chemotaxis Lung Growth Cell Migration Involved In Coronary Angiogenesis Retina Vasculature Development In Camera-type Eye Positive Regulation Of ERK1 And ERK2 Cascade Smooth Muscle Cell Chemotaxis Metanephric Mesenchyme Development Metanephric Glomerular Mesangial Cell Proliferation Involved In Metanephros Development Metanephric Glomerular Capillary Formation Metanephric Comma-shaped Body Morphogenesis Metanephric S-shaped Body Morphogenesis Positive Regulation Of Calcium Ion Import Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Hepatic Stellate Cell Activation Positive Regulation Of DNA Biosynthetic Process	Positive Regulation Of Endothelial Cell Proliferation Regulation Of Transcription By RNA Polymerase II Defense Response Receptor Signaling Pathway Via JAK-STAT Lactation Cytokine-mediated Signaling Pathway Taurine Metabolic Process Interleukin-15-mediated Signaling Pathway Reelin-mediated Signaling Pathway Interleukin-2-mediated Signaling Pathway Interleukin-7-mediated Signaling Pathway Interleukin-9-mediated Signaling Pathway Regulation Of Multicellular Organism Growth Regulation Of Cell Population Proliferation Response To Peptide Hormone Positive Regulation Of Blood Vessel Endothelial Cell Migration Growth Hormone Receptor Signaling Pathway Via JAK-STAT
Pathways		PIP3 activates AKT signaling Downstream signal transduction Signaling by PDGF Constitutive Signaling by Aberrant PI3K in Cancer RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	Prolactin receptor signaling Nuclear signaling by ERBB4 Interleukin-7 signaling Interleukin-7 signaling Signaling by SCF-KIT Signaling by cytosolic FGFR1 fusion mutants Downstream signal transduction Signaling by Leptin Interleukin-3, Interleukin-5 and GM-CSF signaling Interleukin-3, Interleukin-5 and GM-CSF signaling Interleukin-20 family signaling Interleukin-15 signaling Interleukin-9 signaling Interleukin-2 signaling Interleukin-2 signaling Interleukin-21 signaling Erythropoietin activates STAT5 STAT5 Activation Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants STAT5 activation downstream of FLT3 ITD mutants Signaling by FLT3 fusion proteins Growth hormone receptor signaling Growth hormone receptor signaling
Drugs		Becaplermin Sorafenib Imatinib Dasatinib Sunitinib XL999 XL820 Pazopanib Midostaurin Regorafenib Nintedanib Polaprezinc Trapidil Foreskin fibroblast (neonatal) Fostamatinib Erdafitinib Pexidartinib Ripretinib Pralsetinib
Diseases		Glioma
GWAS		Blood protein levels ( 30072576 29875488 28240269) Cytokine network levels (multivariate analysis) ( 31679650) Granulocyte percentage of myeloid white cells ( 27863252) Inflammatory biomarkers (multivariate analysis) ( 33110245) Monocyte count ( 27863252) Monocyte percentage of white cells ( 32888494 27863252)	Asthma (childhood onset) ( 31036433) Crohn's disease ( 28067908) Heel bone mineral density ( 30598549) Inflammatory bowel disease ( 27569725 28067908 23128233) Low density lipoprotein cholesterol levels ( 32154731) Ulcerative colitis ( 28067908)
Interacting Genes		76 interacting genes: ABL1 ABL2 ARAF BAG1 CAV1 CAV3 CBL CEP76 COPA COPB1 CRK EGFR EIF2AK2 ERBB2 FGFR1 FYN GAB1 GRB10 GRB14 GRB2 GRB7 ITGB3 JAK1 JAK2 KLHL12 KPRP KRT31 KRT34 KRTAP10-9 KRTAP12-3 KRTAP4-12 NCK1 NCK2 NEDD4 PDAP1 PDGFB PDGFD PDGFRA PIK3C2B PIK3CA PIK3R1 PIK3R2 PIK3R3 PLCG1 PPM1L PRDX2 PTEN PTK2 PTPN1 PTPN11 PTPN2 PTPN6 PTPRJ RAF1 RASA1 RPS6KB2 S1PR1 SHC1 SLC9A3R1 SLC9A3R2 SNX1 SNX2 SNX4 SOCS1 SRC STAT1 STAT3 STAT5A STAT5B SYNGAP1 TNK2 TPTE TRIP6 TYK2 VAV1 YES1	72 interacting genes: AQP11 BMX BRCA1 BRCA2 BTK CBL CCR5 CD247 CEBPB CENPJ CRK CRKL CSNK2B CTLA4 CYP2C9 EGFR EP300 EPAS1 EPOR ERBB4 ESR1 ESR2 FBXW7 FN1 GHR GLUD1 GNB2 HELZ IL2RB IL2RG IL7R INSR JAK1 JAK2 JAK3 KIT LCK MAGEA12 MAPK1 MAPK3 MRPS6 NCOR2 NMI NR3C1 OLIG1 PDGFRA PDGFRB POM121C POU2F1 PPIB PPP2CA PRMT1 PRTFDC1 PTPN1 PTPN11 PTPN2 RBMX SHC1 SRC STAP2 STAT1 STAT3 STAT5B SYK TCF12 TEK TET2 TSLP TXNDC11 UGT2B4 WASH2P ZNF596
Entrez ID		5159	6776
HPRD ID		01423	03301
Ensembl ID		ENSG00000113721	ENSG00000126561
Uniprot IDs		P09619 Q59F04	A0A384N5W4 A8K6I5 K7EK35 P42229 Q59GY7
PDB IDs		1GQ5 1H9O 1LWP 1SHA 2IUI 2L6W 2PLD 2PLE 3MJG
Enriched GO Terms of Interacting Partners?
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