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PDGFRB and KRTAP10-9
Data Source:
BioGRID
(two hybrid)
PDGFRB
KRTAP10-9
Description
platelet derived growth factor receptor beta
keratin associated protein 10-9
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Golgi Apparatus
Plasma Membrane
Integral Component Of Plasma Membrane
Focal Adhesion
Cell Surface
Membrane
Apical Plasma Membrane
Intrinsic Component Of Plasma Membrane
Cytoplasmic Vesicle
Lysosomal Lumen
Intracellular Membrane-bounded Organelle
Receptor Complex
Cytosol
Keratin Filament
Molecular Function
Protein Tyrosine Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
Platelet Activating Factor Receptor Activity
Platelet-derived Growth Factor-activated Receptor Activity
Platelet-derived Growth Factor Beta-receptor Activity
Signaling Receptor Binding
Platelet-derived Growth Factor Receptor Binding
Protein Binding
ATP Binding
Growth Factor Binding
Enzyme Binding
Protein Kinase Binding
Vascular Endothelial Growth Factor Binding
Phosphatidylinositol 3-kinase Binding
Platelet-derived Growth Factor Binding
Protein Binding
Biological Process
MAPK Cascade
Glycosaminoglycan Biosynthetic Process
Signal Transduction
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
G Protein-coupled Receptor Signaling Pathway
Multicellular Organism Development
Aging
Positive Regulation Of Cell Population Proliferation
Male Gonad Development
Response To Toxic Substance
Positive Regulation Of Phospholipase C Activity
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Positive Regulation Of Smooth Muscle Cell Migration
Cell Migration
Peptidyl-tyrosine Phosphorylation
Positive Regulation Of Cell Migration
Response To Estradiol
Positive Regulation Of Phosphoprotein Phosphatase Activity
Response To Retinoic Acid
Regulation Of Actin Cytoskeleton Organization
Positive Regulation Of Collagen Biosynthetic Process
Positive Regulation Of Kinase Activity
Response To Fluid Shear Stress
Positive Regulation Of Rho Protein Signal Transduction
Cell Migration Involved In Vasculogenesis
Metanephric Mesenchymal Cell Migration
Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Aorta Morphogenesis
Cellular Response To Platelet-derived Growth Factor Stimulus
Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway
Wound Healing
Response To Hydrogen Peroxide
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Positive Regulation Of MAP Kinase Activity
Positive Regulation Of Phosphatidylinositol 3-kinase Activity
Response To Estrogen
Positive Regulation Of Mitotic Nuclear Division
Phosphatidylinositol Metabolic Process
Protein Autophosphorylation
Platelet-derived Growth Factor Receptor Signaling Pathway
Phosphatidylinositol-mediated Signaling
Positive Regulation Of Fibroblast Proliferation
Positive Regulation Of Smooth Muscle Cell Proliferation
Inner Ear Development
Positive Regulation Of Chemotaxis
Positive Regulation Of Protein Kinase B Signaling
Cardiac Myofibril Assembly
Response To Hyperoxia
Cell Chemotaxis
Lung Growth
Cell Migration Involved In Coronary Angiogenesis
Retina Vasculature Development In Camera-type Eye
Positive Regulation Of ERK1 And ERK2 Cascade
Smooth Muscle Cell Chemotaxis
Metanephric Mesenchyme Development
Metanephric Glomerular Mesangial Cell Proliferation Involved In Metanephros Development
Metanephric Glomerular Capillary Formation
Metanephric Comma-shaped Body Morphogenesis
Metanephric S-shaped Body Morphogenesis
Positive Regulation Of Calcium Ion Import
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Positive Regulation Of Hepatic Stellate Cell Activation
Positive Regulation Of DNA Biosynthetic Process
Keratinization
Pathways
PIP3 activates AKT signaling
Downstream signal transduction
Signaling by PDGF
Constitutive Signaling by Aberrant PI3K in Cancer
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Keratinization
Drugs
Becaplermin
Sorafenib
Imatinib
Dasatinib
Sunitinib
XL999
XL820
Pazopanib
Midostaurin
Regorafenib
Nintedanib
Polaprezinc
Trapidil
Foreskin fibroblast (neonatal)
Fostamatinib
Erdafitinib
Pexidartinib
Ripretinib
Pralsetinib
Diseases
Glioma
GWAS
Blood protein levels (
30072576
29875488
28240269
)
Cytokine network levels (multivariate analysis) (
31679650
)
Granulocyte percentage of myeloid white cells (
27863252
)
Inflammatory biomarkers (multivariate analysis) (
33110245
)
Monocyte count (
27863252
)
Monocyte percentage of white cells (
32888494
27863252
)
Interacting Genes
76 interacting genes:
ABL1
ABL2
ARAF
BAG1
CAV1
CAV3
CBL
CEP76
COPA
COPB1
CRK
EGFR
EIF2AK2
ERBB2
FGFR1
FYN
GAB1
GRB10
GRB14
GRB2
GRB7
ITGB3
JAK1
JAK2
KLHL12
KPRP
KRT31
KRT34
KRTAP10-9
KRTAP12-3
KRTAP4-12
NCK1
NCK2
NEDD4
PDAP1
PDGFB
PDGFD
PDGFRA
PIK3C2B
PIK3CA
PIK3R1
PIK3R2
PIK3R3
PLCG1
PPM1L
PRDX2
PTEN
PTK2
PTPN1
PTPN11
PTPN2
PTPN6
PTPRJ
RAF1
RASA1
RPS6KB2
S1PR1
SHC1
SLC9A3R1
SLC9A3R2
SNX1
SNX2
SNX4
SOCS1
SRC
STAT1
STAT3
STAT5A
STAT5B
SYNGAP1
TNK2
TPTE
TRIP6
TYK2
VAV1
YES1
226 interacting genes:
ADAMTSL4
ALDH3B1
ALPI
ANKS1A
ARFGAP1
ATXN7L1
AVPI1
BCL6B
BMP7
BRME1
C10orf62
C11orf87
C22orf39
C5orf60
CATIP
CATSPER1
CBX2
CCDC26
CD300LG
CDKL3
CHIC2
CHRD
CHRNG
CKS1B
CLK4
CNNM3
CRCT1
CREB5
CST9L
CXCL16
CYSRT1
DHRS1
DHX57
DMRT3
DOCK2
EIF4E2
EZH2
FAM124B
FAM161A
FAM74A4
FAM76B
FARS2
FBXW5
GABARAPL1
GABARAPL2
GATA2
GLIDR
GLP1R
GLRX3
GNE
GPATCH2L
GSTP1
GUCD1
HBG1
HBZ
HCK
HES6
HOXA1
HOXB9
HOXC8
HPCAL1
HSBP1
HSD3B7
IGSF8
INPP5D
IQUB
ITGB4
ITGB5
KAT5
KIAA0040
KIF9
KLHL38
KRT20
KRT83
KRTAP1-1
KRTAP1-3
KRTAP10-3
KRTAP10-7
KRTAP10-8
KRTAP12-1
KRTAP12-3
KRTAP26-1
KRTAP4-11
KRTAP4-12
KRTAP4-2
KRTAP5-11
KRTAP5-6
KRTAP5-9
KRTAP9-2
KRTAP9-3
KRTAP9-4
LCE1A
LCE1B
LCE1D
LCE1E
LCE1F
LCE2A
LCE2B
LCE2C
LCE2D
LCE3A
LCE3B
LCE3C
LCE3D
LCE3E
LCE4A
LCE5A
LUZP4
MAB21L3
MAPKBP1
MAZ
MED30
MEOX2
MOBP
MT1DP
MXI1
MYPOP
NAXD
NBPF19
NECTIN3
NKD1
NOTCH2NLA
NPBWR2
NPDC1
NPPB
NR1D2
NUFIP2
OTX1
PCSK5
PDE9A
PDGFRB
PGAP2
PGLS
PIGS
PIN1
PLSCR1
POU4F2
PRKAA2
PRKAB2
PRPF31
PTGER3
PTPMT1
PVR
RAB7A
RASD1
RHNO1
RSPO2
SCARB1
SCNM1
SEMA3B
SHFL
SLC23A1
SLC6A20
SMARCE1
SMCP
SPACA9
SPATA3
SPATA8
SPG7
SPRY1
SPRY2
STK16
TBC1D16
TBC1D23
TBC1D26
TEDC2
TGOLN2
THAP10
TLE5
TNFRSF6B
TNP2
TRIM41
TRIM42
TXNDC5
TYMSOS
TYRO3
UTP23
VGLL3
WNT11
WT1
WT1-AS
XCL2
YIPF3
YY1
ZBTB24
ZBTB38
ZBTB9
ZFYVE26
ZNF124
ZNF155
ZNF165
ZNF20
ZNF251
ZNF264
ZNF275
ZNF286A
ZNF317
ZNF319
ZNF417
ZNF433
ZNF439
ZNF440
ZNF473
ZNF497
ZNF524
ZNF564
ZNF572
ZNF578
ZNF581
ZNF587
ZNF599
ZNF625
ZNF688
ZNF696
ZNF697
ZNF699
ZNF764
ZNF774
ZNF777
ZNF792
ZNF80
ZNF837
ZNF844
ZNF860
ZSCAN21
ZSCAN26
Entrez ID
5159
386676
HPRD ID
01423
11195
Ensembl ID
ENSG00000113721
ENSG00000221837
Uniprot IDs
P09619
Q59F04
P60411
PDB IDs
1GQ5
1H9O
1LWP
1SHA
2IUI
2L6W
2PLD
2PLE
3MJG
Enriched GO Terms of Interacting Partners
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