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SREBF2 and FHL2
Data Source:
BioGRID
(two hybrid)
SREBF2
FHL2
Description
sterol regulatory element binding transcription factor 2
four and a half LIM domains 2
Image
GO Annotations
Cellular Component
Golgi Membrane
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Cytosol
ER To Golgi Transport Vesicle Membrane
SREBP-SCAP-Insig Complex
Intracellular Membrane-bounded Organelle
Nucleus
Nucleoplasm
Focal Adhesion
Z Disc
M Band
Molecular Function
C-8 Sterol Isomerase Activity
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
Protein Binding
Protein C-terminus Binding
Protein Dimerization Activity
E-box Binding
Sequence-specific Double-stranded DNA Binding
Transcription Coregulator Activity
Transcription Corepressor Activity
Protein Binding
Transcription Factor Binding
Identical Protein Binding
BHLH Transcription Factor Binding
Metal Ion Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Transcription By RNA Polymerase II
Lipid Metabolic Process
Cholesterol Metabolic Process
Regulation Of Notch Signaling Pathway
Cellular Response To Starvation
Positive Regulation Of Cholesterol Storage
SREBP Signaling Pathway
Cholesterol Homeostasis
Regulation Of Cholesterol Biosynthetic Process
Positive Regulation Of Transcription By RNA Polymerase II
Cellular Response To Low-density Lipoprotein Particle Stimulus
Cellular Response To Laminar Fluid Shear Stress
Negative Regulation Of Cholesterol Efflux
Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II
Regulation Of Autophagy Of Mitochondrion
Positive Regulation Of Protein Targeting To Mitochondrion
Negative Regulation Of Transcription By RNA Polymerase II
Osteoblast Differentiation
Response To Hormone
Regulation Of Lipid Metabolic Process
Negative Regulation Of Apoptotic Process
Atrial Cardiac Muscle Cell Development
Ventricular Cardiac Muscle Cell Development
Heart Trabecula Formation
Negative Regulation Of Calcineurin-NFAT Signaling Cascade
Pathways
Regulation of cholesterol biosynthesis by SREBP (SREBF)
Regulation of cholesterol biosynthesis by SREBP (SREBF)
PPARA activates gene expression
Activation of gene expression by SREBF (SREBP)
Activation of gene expression by SREBF (SREBP)
Transcriptional regulation of white adipocyte differentiation
EGR2 and SOX10-mediated initiation of Schwann cell myelination
PPARA activates gene expression
Drugs
Diseases
GWAS
Amyotrophic lateral sclerosis (sporadic) (
24529757
)
Birth weight (
31043758
27680694
)
General cognitive ability (
29844566
)
Processed meat consumption (
32066663
)
Refractive error (
32231278
)
Schizophrenia (
25056061
29483656
)
Body fat mass (
28552196
)
Household income (MTAG) (
31844048
)
Lung cancer in ever smokers (
28604730
)
PR interval (
32439900
)
Pulse pressure (
30224653
30578418
)
Interacting Genes
50 interacting genes:
ABLIM1
ABLIM2
ARHGEF1
ARRB1
ATF7IP
ATXN1
AURKA
CASP3
CASP8AP2
COPS5
CREB1
CREBBP
EGR1
EP300
FHL2
FHL3
GOLGB1
HNF4A
HSPA5
INSIG1
INSIG2
ITGB4
KLF13
KPNB1
LINC00839
LZTR1
MAPK1
MAPK3
MRPS6
MTNR1B
NAE1
NFYA
NFYC
OS9
PIAS1
PIAS2
PIAS3
PSMD4
RAB11B
SCAP
SLC4A4
SMAD3
SP1
SPTBN1
SUMO1
TTC1
UBE2I
ZDHHC17
ZMYM2
ZYX
174 interacting genes:
A1CF
ABI1
ABLIM1
ADAM17
AK1
AKIP1
AMOT
ANKRD55
APP
AR
ARHGAP9
ATXN1
BANP
BARX2
BIN1
BLZF1
BMPR2
BRCA1
C20orf85
C2CD6
CAND2
CAPN1
CARD8
CCDC198
CCDC92
CKM
CREBBP
CSK
CSN2
CTNNB1
DAPL1
DCP1A
DDIT4L
DEAF1
DLGAP1
DPF2
DTX2
DUSP10
E2F1
E2F2
E2F3
E2F4
EP300
ESR1
FAM204A
FAM214B
FHL1
FHL3
FHL5
FOXO1
GAS8
GATAD2B
GLYR1
GMEB2
GNG12
GNG4
GOLGA6A
GTF2F2
GTF2H1
HAND1
HCK
HSF2BP
HSPB2
ID3
IDH1
IER3
IFI35
IGFBP5
IKZF1
IKZF4
IL16
INCA1
ITGA3
ITGA7
ITGB1
ITGB2
ITGB5
ITGB6
JUP
KANK2
KIAA1217
KIF5B
KLF12
KPRP
LDLRAP1
LRIF1
MAGEL2
MBD3L1
MCM7
MDM2
MISP
MYBPC1
MYO15B
NBPF6
NIBAN1
NRF1
PFKM
PHB2
PHF1
PHF21A
PKNOX1
PKNOX2
POGZ
POU6F2
PPP1R32
PRDM11
PRDM6
PRR5L
PSEN2
PUF60
QRICH1
RAI2
RASL12
REL
REV1
RFX3
RIPPLY1
RUNX2
SAP30BP
SAXO1
SAXO2
SCNM1
SFPQ
SH3RF1
SIGLEC6
SLAIN1
SLC34A1
SMAD2
SMAD3
SMAD4
SNAI1
SOX30
SP2
SPRY4
SREBF2
SRF
STAT3
SUMO1P1
TCP10L
TNFRSF11A
TOX3
TRAF6
TRIM55
TRIM63
TRIM73
TTN
TXNRD3
VXN
WASHC1
WT1
YPEL3
YY1
ZBTB16
ZBTB25
ZFP64
ZFYVE9
ZMYM4
ZNF131
ZNF143
ZNF200
ZNF212
ZNF23
ZNF3
ZNF331
ZNF408
ZNF410
ZNF417
ZNF620
ZNF626
ZNF638
ZNF655
ZNF76
ZNF85
ZSCAN9
Entrez ID
6721
2274
HPRD ID
02726
04026
Ensembl ID
ENSG00000198911
ENSG00000115641
Uniprot IDs
A0A024R1Q0
Q12772
Q14192
Q2XQU9
Q6I9R8
PDB IDs
1UKL
1X4K
1X4L
2D8Z
2MIU
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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