Wiki-MPM
About
Search
Browse
People
Funding
Updates
Search
SREBF2 and PIAS1
Data Source:
BioGRID
(genetic interference, two hybrid)
SREBF2
PIAS1
Description
sterol regulatory element binding transcription factor 2
protein inhibitor of activated STAT 1
Image
GO Annotations
Cellular Component
Golgi Membrane
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Cytosol
ER To Golgi Transport Vesicle Membrane
SREBP-SCAP-Insig Complex
Intracellular Membrane-bounded Organelle
Nucleus
Nucleoplasm
PML Body
Nuclear Speck
Molecular Function
C-8 Sterol Isomerase Activity
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
Protein Binding
Protein C-terminus Binding
Protein Dimerization Activity
E-box Binding
Sequence-specific Double-stranded DNA Binding
RNA Polymerase II Transcription Factor Binding
DNA Binding
Transcription Coregulator Activity
Transcription Corepressor Activity
Protein Binding
Protein C-terminus Binding
Zinc Ion Binding
SUMO Transferase Activity
Enzyme Binding
Protein Domain Specific Binding
Ubiquitin Protein Ligase Binding
SUMO Ligase Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Transcription By RNA Polymerase II
Lipid Metabolic Process
Cholesterol Metabolic Process
Regulation Of Notch Signaling Pathway
Cellular Response To Starvation
Positive Regulation Of Cholesterol Storage
SREBP Signaling Pathway
Cholesterol Homeostasis
Regulation Of Cholesterol Biosynthetic Process
Positive Regulation Of Transcription By RNA Polymerase II
Cellular Response To Low-density Lipoprotein Particle Stimulus
Cellular Response To Laminar Fluid Shear Stress
Negative Regulation Of Cholesterol Efflux
Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II
Regulation Of Autophagy Of Mitochondrion
Positive Regulation Of Protein Targeting To Mitochondrion
G1/S Transition Of Mitotic Cell Cycle
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Transcription By RNA Polymerase II
Receptor Signaling Pathway Via JAK-STAT
Spermatogenesis
Visual Learning
Protein Sumoylation
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Protein Sumoylation
Regulation Of Cell Population Proliferation
Negative Regulation Of Apoptotic Process
Fat Cell Differentiation
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Smooth Muscle Cell Differentiation
Regulation Of Interferon-gamma-mediated Signaling Pathway
Protein-DNA Complex Assembly
Pathways
Regulation of cholesterol biosynthesis by SREBP (SREBF)
Regulation of cholesterol biosynthesis by SREBP (SREBF)
PPARA activates gene expression
Activation of gene expression by SREBF (SREBP)
Activation of gene expression by SREBF (SREBP)
Transcriptional regulation of white adipocyte differentiation
EGR2 and SOX10-mediated initiation of Schwann cell myelination
SUMOylation of DNA damage response and repair proteins
SUMOylation of transcription factors
SUMOylation of ubiquitinylation proteins
SUMOylation of transcription cofactors
SUMOylation of intracellular receptors
SUMOylation of intracellular receptors
SUMOylation of chromatin organization proteins
Formation of Incision Complex in GG-NER
Regulation of IFNG signaling
Drugs
Diseases
GWAS
Amyotrophic lateral sclerosis (sporadic) (
24529757
)
Birth weight (
31043758
27680694
)
General cognitive ability (
29844566
)
Processed meat consumption (
32066663
)
Refractive error (
32231278
)
Schizophrenia (
25056061
29483656
)
Diastolic blood pressure (
30224653
)
Diverticular disease (
30177863
)
Gut microbiota (bacterial taxa, hurdle binary method) (
32572223
)
Major depressive disorder (
23377640
)
Number of twin births (
30760885
)
Interacting Genes
50 interacting genes:
ABLIM1
ABLIM2
ARHGEF1
ARRB1
ATF7IP
ATXN1
AURKA
CASP3
CASP8AP2
COPS5
CREB1
CREBBP
EGR1
EP300
FHL2
FHL3
GOLGB1
HNF4A
HSPA5
INSIG1
INSIG2
ITGB4
KLF13
KPNB1
LINC00839
LZTR1
MAPK1
MAPK3
MRPS6
MTNR1B
NAE1
NFYA
NFYC
OS9
PIAS1
PIAS2
PIAS3
PSMD4
RAB11B
SCAP
SLC4A4
SMAD3
SP1
SPTBN1
SUMO1
TTC1
UBE2I
ZDHHC17
ZMYM2
ZYX
107 interacting genes:
AKT1
AR
ATXN1
AXIN1
BARD1
BRCA1
CASP8
CBS
CDK4
CEBPA
CEBPE
CHUK
CNOT7
CREB1
CREBBP
CSNK2A1
CSRP2
DCLRE1A
DDX21
DDX5
DNM1
DNMT3A
ELK3
EP300
ESR1
ESR2
FANCI
FHL3
FLI1
GATA4
GLUL
GRM8
GSK3B
GTF2IRD1
HECTD2
HIC1
HTT
IKZF5
JUN
KLF3
L3MBTL2
LSM3
MAML1
MBD1
MDC1
MDM2
MITF
MSX1
MX1
MYB
NCOR1
NFATC1
NIN
NR2F2
NR3C2
NR5A1
PAXIP1
PGR
PIAS2
PIAS4
PLAG1
PML
PPP1CA
PPP1CC
PRDM1
PRPF40A
PSME3
PTK2
PTPN1
QKI
RAD54L2
RBBP6
RELA
SATB1
SATB2
SERBP1
SGTA
SKIL
SMAD1
SMAD4
SMAD7
SNAI2
SNIP1
SP3
SPOP
SREBF2
STAT1
SUFU
SUMO1
SUMO1P1
SUMO2
SUMO3
TBP
TERF2
TEX11
TP53
TP73
TRIM27
TRIM5
TRIM55
TRIM63
TSG101
UBE2I
UBE2L3
YWHAZ
ZNF451
ZNF76
Entrez ID
6721
8554
HPRD ID
02726
16029
Ensembl ID
ENSG00000198911
ENSG00000033800
Uniprot IDs
A0A024R1Q0
Q12772
O75925
Q1XBU8
PDB IDs
1UKL
1V66
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?