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FHL2 and PHB2
Data Source:
BioGRID
(two hybrid)
FHL2
PHB2
Description
four and a half LIM domains 2
prohibitin 2
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Focal Adhesion
Z Disc
M Band
Nucleus
Cytoplasm
Mitochondrion
Mitochondrial Outer Membrane
Mitochondrial Inner Membrane
Plasma Membrane
Cell Surface
Postsynaptic Density
Nuclear Matrix
Axon
Protein-containing Complex
Mitochondrial Prohibitin Complex
Presynaptic Active Zone
Cell Periphery
Glutamatergic Synapse
GABA-ergic Synapse
Molecular Function
Transcription Coregulator Activity
Transcription Corepressor Activity
Protein Binding
Transcription Factor Binding
Identical Protein Binding
BHLH Transcription Factor Binding
Metal Ion Binding
Protein Binding
Protein C-terminus Binding
Estrogen Receptor Binding
Amide Binding
Identical Protein Binding
Protein Homodimerization Activity
Sphingolipid Binding
Protein Heterodimerization Activity
Protein N-terminus Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Osteoblast Differentiation
Response To Hormone
Regulation Of Lipid Metabolic Process
Negative Regulation Of Apoptotic Process
Atrial Cardiac Muscle Cell Development
Ventricular Cardiac Muscle Cell Development
Heart Trabecula Formation
Negative Regulation Of Calcineurin-NFAT Signaling Cascade
Activation Of MAPK Activity
Mitophagy
Immunoglobulin Production
Protein Import Into Nucleus
Mitochondrial Calcium Ion Transmembrane Transport
Mitochondrion Organization
Sister Chromatid Cohesion
Activation Of Phospholipase C Activity
Response To Wounding
Cell Migration
CD40 Signaling Pathway
Regulation Of Complement Activation
Positive Regulation Of Exit From Mitosis
Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway
Negative Regulation Of Mammary Gland Epithelial Cell Proliferation
Induction By Virus Of Host Autophagy
RIG-I Signaling Pathway
B Cell Activation
Negative Regulation Of Apoptotic Process
Negative Regulation Of DNA-binding Transcription Factor Activity
Negative Regulation Of Transcription, DNA-templated
Protein Stabilization
Positive Regulation Of DNA-binding Transcription Factor Activity
Mammary Gland Branching Involved In Thelarche
Mammary Gland Alveolus Development
Regulation Of Branching Involved In Mammary Gland Duct Morphogenesis
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Retinoic Acid
Cellular Response To Hypoxia
Antiviral Innate Immune Response
Regulation Of Cardiolipin Metabolic Process
Positive Regulation Of NIK/NF-kappaB Signaling
Positive Regulation Of Cell Cycle G1/S Phase Transition
Regulation Of Cytochrome-c Oxidase Activity
Activation Of Protein Kinase C Activity
Pathways
PPARA activates gene expression
Processing of SMDT1
Drugs
Capsaicin
Rocaglamide
Didesmethylrocaglamide
Diseases
GWAS
Body fat mass (
28552196
)
Household income (MTAG) (
31844048
)
Lung cancer in ever smokers (
28604730
)
PR interval (
32439900
)
Pulse pressure (
30224653
30578418
)
Glycated hemoglobin levels (
28898252
)
Red blood cell fatty acid levels (
25500335
)
Refractive error (
32231278
)
Interacting Genes
174 interacting genes:
A1CF
ABI1
ABLIM1
ADAM17
AK1
AKIP1
AMOT
ANKRD55
APP
AR
ARHGAP9
ATXN1
BANP
BARX2
BIN1
BLZF1
BMPR2
BRCA1
C20orf85
C2CD6
CAND2
CAPN1
CARD8
CCDC198
CCDC92
CKM
CREBBP
CSK
CSN2
CTNNB1
DAPL1
DCP1A
DDIT4L
DEAF1
DLGAP1
DPF2
DTX2
DUSP10
E2F1
E2F2
E2F3
E2F4
EP300
ESR1
FAM204A
FAM214B
FHL1
FHL3
FHL5
FOXO1
GAS8
GATAD2B
GLYR1
GMEB2
GNG12
GNG4
GOLGA6A
GTF2F2
GTF2H1
HAND1
HCK
HSF2BP
HSPB2
ID3
IDH1
IER3
IFI35
IGFBP5
IKZF1
IKZF4
IL16
INCA1
ITGA3
ITGA7
ITGB1
ITGB2
ITGB5
ITGB6
JUP
KANK2
KIAA1217
KIF5B
KLF12
KPRP
LDLRAP1
LRIF1
MAGEL2
MBD3L1
MCM7
MDM2
MISP
MYBPC1
MYO15B
NBPF6
NIBAN1
NRF1
PFKM
PHB2
PHF1
PHF21A
PKNOX1
PKNOX2
POGZ
POU6F2
PPP1R32
PRDM11
PRDM6
PRR5L
PSEN2
PUF60
QRICH1
RAI2
RASL12
REL
REV1
RFX3
RIPPLY1
RUNX2
SAP30BP
SAXO1
SAXO2
SCNM1
SFPQ
SH3RF1
SIGLEC6
SLAIN1
SLC34A1
SMAD2
SMAD3
SMAD4
SNAI1
SOX30
SP2
SPRY4
SREBF2
SRF
STAT3
SUMO1P1
TCP10L
TNFRSF11A
TOX3
TRAF6
TRIM55
TRIM63
TRIM73
TTN
TXNRD3
VXN
WASHC1
WT1
YPEL3
YY1
ZBTB16
ZBTB25
ZFP64
ZFYVE9
ZMYM4
ZNF131
ZNF143
ZNF200
ZNF212
ZNF23
ZNF3
ZNF331
ZNF408
ZNF410
ZNF417
ZNF620
ZNF626
ZNF638
ZNF655
ZNF76
ZNF85
ZSCAN9
21 interacting genes:
AFP
AKT1
CDC42
ESR1
EZH2
FHL2
HDAC1
HDAC2
HDAC3
HDAC5
MEF2A
MYOD1
NR2F1
NR2F2
PPARG
PRKCA
PTEN
PTMA
RNF2
TEAD3
UPF2
Entrez ID
2274
11331
HPRD ID
04026
17843
Ensembl ID
ENSG00000115641
ENSG00000215021
Uniprot IDs
Q14192
Q2XQU9
Q6I9R8
Q99623
PDB IDs
1X4K
1X4L
2D8Z
2MIU
6IQE
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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