STAT5B and LGALS14

Data Source:
BioGRID (two hybrid)

		STAT5B	LGALS14
Description		signal transducer and activator of transcription 5B	galectin 14
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol	Nucleoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Glucocorticoid Receptor Binding Identical Protein Binding Protein Dimerization Activity	Protein Binding Carbohydrate Binding
	Biological Process	Luteinization Natural Killer Cell Differentiation Regulation Of Transcription By RNA Polymerase II Defense Response Receptor Signaling Pathway Via JAK-STAT Female Pregnancy Lactation Regulation Of Steroid Metabolic Process Cytokine-mediated Signaling Pathway Taurine Metabolic Process Lipid Storage Regulation Of Epithelial Cell Differentiation Response To Estradiol Positive Regulation Of Interleukin-2 Production Positive Regulation Of Natural Killer Cell Proliferation Positive Regulation Of Natural Killer Cell Differentiation Cellular Response To Hormone Stimulus T Cell Differentiation In Thymus Interleukin-15-mediated Signaling Pathway Interleukin-2-mediated Signaling Pathway Interleukin-7-mediated Signaling Pathway Interleukin-9-mediated Signaling Pathway Regulation Of Multicellular Organism Growth Positive Regulation Of Multicellular Organism Growth Positive Regulation Of Activated T Cell Proliferation Regulation Of Cell Population Proliferation Progesterone Metabolic Process T Cell Homeostasis Negative Regulation Of Apoptotic Process Response To Peptide Hormone Positive Regulation Of B Cell Differentiation Positive Regulation Of Gamma-delta T Cell Differentiation Negative Regulation Of Erythrocyte Differentiation Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Development Of Secondary Female Sexual Characteristics Development Of Secondary Male Sexual Characteristics Peyer's Patch Development Positive Regulation Of Inflammatory Response Growth Hormone Receptor Signaling Pathway Via JAK-STAT Response To Interleukin-4 Cellular Response To Growth Factor Stimulus Cellular Response To Epidermal Growth Factor Stimulus Mast Cell Migration	Apoptotic Process Positive Regulation Of T Cell Apoptotic Process
Pathways		Prolactin receptor signaling Interleukin-7 signaling Interleukin-7 signaling Signaling by SCF-KIT Signaling by cytosolic FGFR1 fusion mutants Downstream signal transduction Signaling by Leptin Interleukin-3, Interleukin-5 and GM-CSF signaling Interleukin-3, Interleukin-5 and GM-CSF signaling Interleukin-20 family signaling Interleukin-15 signaling Interleukin-9 signaling Interleukin-2 signaling Interleukin-2 signaling Interleukin-21 signaling Erythropoietin activates STAT5 STAT5 Activation Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants STAT5 activation downstream of FLT3 ITD mutants Signaling by FLT3 fusion proteins Growth hormone receptor signaling Growth hormone receptor signaling
Drugs		Dasatinib
Diseases		Growth hormone insensitivity with immunodeficiency
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 31361310 32296059) Asthma (childhood onset) ( 31036433) Crohn's disease ( 28067908) Inflammatory bowel disease ( 27569725 28067908 23128233) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Monocyte count ( 32888494) Neutrophil percentage of white cells ( 32888494) Paracentral lobule volume ( 31530798) Ulcerative colitis ( 28067908)	Sum eosinophil basophil counts ( 27863252)
Interacting Genes		62 interacting genes: AFTPH APP CBL CD247 CDKN1A CENPJ CHAF1A CRK CRKL CTLA4 CXCR4 DMRTA1 EGFR ELP2 EP300 EPOR ERBB4 ETS1 ETS2 GHR HAX1 HNRNPA2B1 IL15 IL2RA IL2RB IL7R INSR JAK2 JAK3 KIT LGALS14 LMO4 MAPK1 MED25 MRPS6 NCOR2 NMI NR3C1 PDGFRA PDGFRB PIK3R3 POU2F1 PPP2CA PTPN1 PTPN11 PTPN2 PTPN6 RARA RBBP4 SERTAD1 SHC1 SRC STAC STAP2 STAT1 STAT3 STAT5A SUOX TEK TFG TSSK3 USP2	46 interacting genes: ADAMTSL4 AJUBA BANP BLZF1 C1QTNF2 COG6 CRLF3 DDIT4L DOK6 FCHO1 FLACC1 FLNA GFAP IKZF3 IL16 JRK KRT19 KRT35 LNX1 LNX2 MEI4 MID2 NFKBID PCBD2 PICK1 POF1B PPM1J REL RIMBP3C SDCBP2 SH3GLB2 SPAG5 STAT5B TARS3 TBC1D25 TCF4 TEKT1 TEPSIN TNR TRIM23 TRIM27 VIM ZBTB8A ZNF438 ZNF655 ZNF71
Entrez ID		6777	56891
HPRD ID		05037	06268
Ensembl ID		ENSG00000173757	ENSG00000006659
Uniprot IDs		P51692	Q8TCE9
PDB IDs		6MBW 6MBZ	6K2Y 6K2Z
Enriched GO Terms of Interacting Partners?
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