SNRNP70 and SHBG

Data Source:
BioGRID (two hybrid)

		SNRNP70	SHBG
Description		small nuclear ribonucleoprotein U1 subunit 70	sex hormone binding globulin
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex U1 SnRNP Nuclear Speck U2-type Prespliceosome	Extracellular Region Extracellular Exosome
	Molecular Function	RNA Binding MRNA Binding Protein Binding SnRNA Binding U1 SnRNA Binding	Steroid Binding Androgen Binding Protein Binding
	Biological Process	MRNA Splicing, Via Spliceosome Regulation Of ATPase Activity Regulation Of RNA Splicing Positive Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of Protein Refolding Negative Regulation Of Chaperone-mediated Autophagy
Pathways		mRNA Splicing - Major Pathway
Drugs			Masoprocol Diethylstilbestrol Levonorgestrel Progesterone Spironolactone Toremifene Estrone Tamoxifen Clomifene Dienestrol Hesperetin Zinc Genistein Naringenin Quercetin 4'-Hydroxyflavanone Afimoxifene Estriol Phenolphthalein Norethynodrel Dioxybenzone Zeranol Gestrinone Equol Zinc acetate Zinc chloride Zinc sulfate, unspecified form Estriol tripropionate
Diseases
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Systolic blood pressure ( 30224653)	Androgen levels ( 22936694) Body size at age 10 ( 32376654) Brain morphology (MOSTest) ( 32665545) Heel bone mineral density ( 30598549) Hormone measurements ( 24049095) Medication use (calcium channel blockers) ( 31015401) Protein quantitative trait loci ( 18464913) Red cell distribution width ( 27863252) Refractive error ( 32231278) Sex hormone levels ( 26014426) Sex hormone-binding globulin levels ( 22675492 22829776) Testosterone levels ( 21998597) Uterine fibroids ( 31649266)
Interacting Genes		46 interacting genes: APP ARSF CASP3 CDC42 CDKL3 CEP63 CHERP CLK2 CRP CTDP1 DDX17 GEMIN2 GTPBP2 HNRNPA2B1 HTATSF1 IL32 IL7R LRP1 MYC NUDT21 PRKD2 PRMT5 PRPF40A RASGRF1 RELA RNF11 SCAF11 SHBG SKIL SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD9 SMURF2 SNRPC SRPK1 SRPK2 SRRM4 SRSF1 SRSF10 SRSF2 TOP1 WBP4 ZRANB2	62 interacting genes: A2M ACP3 ACTA2 ACTB ACTG2 AK2 AKR1B1 AP1B1 AP2A1 APEH APOBEC3C APOD ASB16-AS1 ATP5F1A AZGP1 C9orf24 CD177 CEP192 CLDN4 CLEC4G COL1A2 CTSD DDX3Y DES DSTN EEF1A1 EIF3E EIF3F FLNA FLOT1 FYTTD1 GRB2 HDHD5 HYI JMJD7-PLA2G4B KLK4 MPDU1 MT1F MT1G MT2A MXD4 NOMO1 PACSIN2 PKM PLA2G4A PLP2 PSTPIP1 PSTPIP2 PTGDS RMND5B SEMA3F SLC37A1 SLC37A4 SNAPIN SNRNP70 SORD SRF SRI TINAGL1 UBE2O UBE3A ZC3H12A
Entrez ID		6625	6462
HPRD ID		01617	01646
Ensembl ID		ENSG00000104852	ENSG00000129214
Uniprot IDs		A0A024QZD5 P08621 Q9UFS1	B0FWH2 B0FWH8 B4DYU0 I3L145 P04278
PDB IDs		2L5I 2L5J 3CW1 3PGW 4PJO 4PKD 6QX9	1D2S 1F5F 1KDK 1KDM 1LHN 1LHO 1LHU 1LHV 1LHW 6PYA 6PYB 6PYF 6ULB
Enriched GO Terms of Interacting Partners?
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