SNRNP70 and CRP

Data Source:
HPRD (in vivo)

		SNRNP70	CRP
Description		small nuclear ribonucleoprotein U1 subunit 70	C-reactive protein
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex U1 SnRNP Nuclear Speck U2-type Prespliceosome	Extracellular Region Extracellular Space
	Molecular Function	RNA Binding MRNA Binding Protein Binding SnRNA Binding U1 SnRNA Binding	Complement Component C1q Complex Binding Calcium Ion Binding Protein Binding Low-density Lipoprotein Particle Binding Choline Binding Identical Protein Binding Virion Binding Low-density Lipoprotein Particle Receptor Binding
	Biological Process	MRNA Splicing, Via Spliceosome Regulation Of ATPase Activity Regulation Of RNA Splicing Positive Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of Protein Refolding Negative Regulation Of Chaperone-mediated Autophagy	Acute-phase Response Inflammatory Response Complement Activation, Classical Pathway Opsonization Positive Regulation Of Gene Expression Negative Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Lipid Storage Regulation Of Interleukin-8 Production Positive Regulation Of Superoxide Anion Generation Negative Regulation Of Mononuclear Cell Proliferation Vasoconstriction Negative Regulation By Host Of Viral Process Innate Immune Response Defense Response To Gram-positive Bacterium
Pathways		mRNA Splicing - Major Pathway	Classical antibody-mediated complement activation
Drugs			N,N,N-Trimethyl-2-(phosphonooxy)ethanaminium CRx-139
Diseases			Systemic lupus erythematosus
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Systolic blood pressure ( 30224653)	Blood protein levels ( 30072576 29875488 23696881) C-reactive protein ( 22492993 19567438 21647738 18439548 18439552 21196492 23844046 22939635) C-reactive protein levels ( 24763700 29403010 30388399 21300955 28548082) C-reactive protein levels in ischemic stroke ( 26718567) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Inflammatory biomarkers ( 22291609) Inflammatory biomarkers in Kawasaki disease ( 25266886) Lung cancer ( 18385676) Metabolic traits ( 19060910) Protein quantitative trait loci ( 18464913) Select biomarker traits ( 17903293)
Interacting Genes		46 interacting genes: APP ARSF CASP3 CDC42 CDKL3 CEP63 CHERP CLK2 CRP CTDP1 DDX17 GEMIN2 GTPBP2 HNRNPA2B1 HTATSF1 IL32 IL7R LRP1 MYC NUDT21 PRKD2 PRMT5 PRPF40A RASGRF1 RELA RNF11 SCAF11 SHBG SKIL SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD9 SMURF2 SNRPC SRPK1 SRPK2 SRRM4 SRSF1 SRSF10 SRSF2 TOP1 WBP4 ZRANB2	21 interacting genes: APCS C1QA CFH ESS2 FCGR1A FCGR2A FCGR2B FN1 GLUD1 GMPPA GP6 H1-1 H2AC16 H2AC20 LAMC3 LEP MAPK1 MAPK3 MAPK8IP2 RPL13A SNRNP70
Entrez ID		6625	1401
HPRD ID		01617	00422
Ensembl ID		ENSG00000104852	ENSG00000132693
Uniprot IDs		A0A024QZD5 P08621 Q9UFS1	P02741
PDB IDs		2L5I 2L5J 3CW1 3PGW 4PJO 4PKD 6QX9	1B09 1CRV 1GNH 1LJ7 3L2Y 3PVN 3PVO
Enriched GO Terms of Interacting Partners?
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