SNRNP70 and SRSF2

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		SNRNP70	SRSF2
Description		small nuclear ribonucleoprotein U1 subunit 70	serine and arginine rich splicing factor 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex U1 SnRNP Nuclear Speck U2-type Prespliceosome	Nucleus Nucleoplasm Cytoplasm Cytosol PML Body Nuclear Speck
	Molecular Function	RNA Binding MRNA Binding Protein Binding SnRNA Binding U1 SnRNA Binding	Transcription Corepressor Activity RNA Binding Protein Binding
	Biological Process	MRNA Splicing, Via Spliceosome Regulation Of ATPase Activity Regulation Of RNA Splicing Positive Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of Protein Refolding Negative Regulation Of Chaperone-mediated Autophagy	MRNA Splicing, Via Spliceosome MRNA Processing RNA Export From Nucleus MRNA Export From Nucleus RNA Splicing MRNA 3'-end Processing Negative Regulation Of Transcription, DNA-templated
Pathways		mRNA Splicing - Major Pathway	Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination
Drugs
Diseases
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Systolic blood pressure ( 30224653)
Interacting Genes		46 interacting genes: APP ARSF CASP3 CDC42 CDKL3 CEP63 CHERP CLK2 CRP CTDP1 DDX17 GEMIN2 GTPBP2 HNRNPA2B1 HTATSF1 IL32 IL7R LRP1 MYC NUDT21 PRKD2 PRMT5 PRPF40A RASGRF1 RELA RNF11 SCAF11 SHBG SKIL SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD9 SMURF2 SNRPC SRPK1 SRPK2 SRRM4 SRSF1 SRSF10 SRSF2 TOP1 WBP4 ZRANB2	34 interacting genes: ADAP1 BARD1 CCNL1 CCNL2 CDK12 CDK6 CEP72 CIR1 CSNK2A1 FUS GEMIN2 GOLGA2 KAT5 KRT31 KRT40 LIG4 LZTS2 NCF1 PRCC SCAF11 SNRNP70 SREK1 SRPK2 SRSF11 SRSF3 SRSF4 TCF4 TRA2B TRIM27 U2AF1 UBQLN4 YTHDC1 ZRANB2 ZRSR2
Entrez ID		6625	6427
HPRD ID		01617	02888
Ensembl ID		ENSG00000104852	ENSG00000161547
Uniprot IDs		A0A024QZD5 P08621 Q9UFS1	A0A024R8U5 Q01130 Q53FN0
PDB IDs		2L5I 2L5J 3CW1 3PGW 4PJO 4PKD 6QX9	2KN4 2LEA 2LEB 2LEC
Enriched GO Terms of Interacting Partners?
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