SRSF2 and SNRNP70

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		SRSF2	SNRNP70
Description		serine and arginine rich splicing factor 2	small nuclear ribonucleoprotein U1 subunit 70
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol PML Body Nuclear Speck	Nucleus Nucleoplasm Spliceosomal Complex U1 SnRNP Nuclear Speck U2-type Prespliceosome
	Molecular Function	Transcription Corepressor Activity RNA Binding Protein Binding	RNA Binding MRNA Binding Protein Binding SnRNA Binding U1 SnRNA Binding
	Biological Process	MRNA Splicing, Via Spliceosome MRNA Processing RNA Export From Nucleus MRNA Export From Nucleus RNA Splicing MRNA 3'-end Processing Negative Regulation Of Transcription, DNA-templated	MRNA Splicing, Via Spliceosome Regulation Of ATPase Activity Regulation Of RNA Splicing Positive Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of Protein Refolding Negative Regulation Of Chaperone-mediated Autophagy
Pathways		Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination	mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS			Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Systolic blood pressure ( 30224653)
Interacting Genes		34 interacting genes: ADAP1 BARD1 CCNL1 CCNL2 CDK12 CDK6 CEP72 CIR1 CSNK2A1 FUS GEMIN2 GOLGA2 KAT5 KRT31 KRT40 LIG4 LZTS2 NCF1 PRCC SCAF11 SNRNP70 SREK1 SRPK2 SRSF11 SRSF3 SRSF4 TCF4 TRA2B TRIM27 U2AF1 UBQLN4 YTHDC1 ZRANB2 ZRSR2	46 interacting genes: APP ARSF CASP3 CDC42 CDKL3 CEP63 CHERP CLK2 CRP CTDP1 DDX17 GEMIN2 GTPBP2 HNRNPA2B1 HTATSF1 IL32 IL7R LRP1 MYC NUDT21 PRKD2 PRMT5 PRPF40A RASGRF1 RELA RNF11 SCAF11 SHBG SKIL SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD9 SMURF2 SNRPC SRPK1 SRPK2 SRRM4 SRSF1 SRSF10 SRSF2 TOP1 WBP4 ZRANB2
Entrez ID		6427	6625
HPRD ID		02888	01617
Ensembl ID		ENSG00000161547	ENSG00000104852
Uniprot IDs		A0A024R8U5 Q01130 Q53FN0	A0A024QZD5 P08621 Q9UFS1
PDB IDs		2KN4 2LEA 2LEB 2LEC	2L5I 2L5J 3CW1 3PGW 4PJO 4PKD 6QX9
Enriched GO Terms of Interacting Partners?
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