SLC9A3 and SHANK2

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		SLC9A3	SHANK2
Description		solute carrier family 9 member A3	SH3 and multiple ankyrin repeat domains 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Brush Border Cell Surface Integral Component Of Membrane Apical Plasma Membrane Brush Border Membrane Extracellular Exosome	Photoreceptor Outer Segment Photoreceptor Inner Segment Cellular_component Cytosol Neurofilament Plasma Membrane Ionotropic Glutamate Receptor Complex Postsynaptic Density Apical Plasma Membrane Growth Cone Brush Border Membrane Neuron Projection Neuronal Cell Body Dendritic Spine Postsynaptic Membrane Ciliary Membrane
	Molecular Function	Protein Binding Sodium:proton Antiporter Activity Potassium:proton Antiporter Activity PDZ Domain Binding	Protein Binding SH3 Domain Binding Synaptic Receptor Adaptor Activity Ionotropic Glutamate Receptor Binding
	Biological Process	Ion Transport Regulation Of Intracellular PH Potassium Ion Transmembrane Transport Anion Transmembrane Transport Sodium Ion Import Across Plasma Membrane Proton Transmembrane Transport	Synapse Assembly Behavior Learning Positive Regulation Of Cell Population Proliferation Adult Behavior Social Behavior Negative Regulation Of Hippo Signaling Brain Morphogenesis Synaptic Growth At Neuromuscular Junction Positive Regulation Of Synaptic Transmission, Glutamatergic Long-term Synaptic Potentiation Long-term Synaptic Depression Dendritic Spine Morphogenesis Positive Regulation Of Dendritic Spine Development Vocalization Behavior Postsynaptic Density Assembly Regulation Of AMPA Receptor Activity Positive Regulation Of Excitatory Postsynaptic Potential
Pathways		Sodium/Proton exchangers	Neurexins and neuroligins Neurexins and neuroligins
Drugs		Tenapanor
Diseases
GWAS		Anti-thyroglobulin (TgAb) levels in Hashimoto's thyroiditis ( 30926877) Estimated glomerular filtration rate ( 31152163) Lung disease severity in cystic fibrosis ( 26417704) Ulcerative colitis ( 28067908 23128233)	Bipolar disorder ( 31043756) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Hip circumference ( 28552196) Late-onset Alzheimer's disease ( 27770636) Obesity-related traits ( 23251661) Response to fenofibrate (adiponectin levels) ( 23149075) Urate levels in obese individuals ( 25811787)
Interacting Genes		8 interacting genes: CHP1 CHP2 LRP2 MAST2 PDZK1 SHANK2 SLC9A3R1 SLC9A3R2	19 interacting genes: ADGRB2 ADGRL1 ADGRL2 ARHGAP12 ARHGEF7 BAIAP2 CTTN DLG4 DLGAP1 DLGAP2 DLGAP3 DLGAP4 DNM2 HOMER1 PPP3CA RIPOR3 SHARPIN SLC9A3 SSTR2
Entrez ID		6550	22941
HPRD ID		01660	04479
Ensembl ID		ENSG00000066230	ENSG00000162105
Uniprot IDs		P48764	A0A590UJ45 A6NHU9 C0SPH0 Q9UPX8
PDB IDs
Enriched GO Terms of Interacting Partners?
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