SLC9A3 and LRP2

Data Source:
HPRD (in vitro, in vivo)

		SLC9A3	LRP2
Description		solute carrier family 9 member A3	LDL receptor related protein 2
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Brush Border Cell Surface Integral Component Of Membrane Apical Plasma Membrane Brush Border Membrane Extracellular Exosome	Lysosome Lysosomal Membrane Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Clathrin-coated Pit External Side Of Plasma Membrane Integral Component Of Membrane Apical Plasma Membrane Endocytic Vesicle Axon Dendrite Clathrin-coated Vesicle Membrane Brush Border Membrane Endosome Lumen Receptor Complex Extracellular Exosome
	Molecular Function	Protein Binding Sodium:proton Antiporter Activity Potassium:proton Antiporter Activity PDZ Domain Binding	Calcium Ion Binding Protein Binding SH3 Domain Binding Insulin-like Growth Factor I Binding Hormone Binding Chaperone Binding Protein Transporter Activity
	Biological Process	Ion Transport Regulation Of Intracellular PH Potassium Ion Transmembrane Transport Anion Transmembrane Transport Sodium Ion Import Across Plasma Membrane Proton Transmembrane Transport	Retinoid Metabolic Process Kidney Development Neural Tube Closure Secondary Heart Field Specification Outflow Tract Septum Morphogenesis Ventricular Compact Myocardium Morphogenesis Ventricular Septum Development Lipid Metabolic Process Endocytosis Receptor-mediated Endocytosis Sensory Perception Of Sound Cell Population Proliferation Male Gonad Development Protein Transport Metal Ion Transport Negative Regulation Of BMP Signaling Pathway Forebrain Development Aorta Development Vitamin D Metabolic Process Negative Regulation Of Apoptotic Process Response To Leptin Transcytosis Positive Regulation Of Neurogenesis Positive Regulation Of Protein Kinase B Signaling Vagina Development Coronary Artery Morphogenesis Membrane Organization Pulmonary Artery Morphogenesis Positive Regulation Of Oligodendrocyte Progenitor Proliferation Cellular Response To Growth Factor Stimulus Amyloid-beta Clearance Neuron Projection Arborization Transport Across Blood-brain Barrier Folate Import Across Plasma Membrane Positive Regulation Of Lysosomal Protein Catabolic Process
Pathways		Sodium/Proton exchangers	Vitamin D (calciferol) metabolism Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Retinoid metabolism and transport
Drugs		Tenapanor	Urokinase Insulin pork Gentamicin
Diseases			Donnai-Barrow syndrome; Faciooculoacousticorenal syndrome
GWAS		Anti-thyroglobulin (TgAb) levels in Hashimoto's thyroiditis ( 30926877) Estimated glomerular filtration rate ( 31152163) Lung disease severity in cystic fibrosis ( 26417704) Ulcerative colitis ( 28067908 23128233)	Anorexia nervosa ( 21079607) Blood pressure (smoking interaction) ( 25189868) Chronic kidney disease ( 29124443) Creatinine levels ( 29124443 29403010) Estimated glomerular filtration rate ( 31152163 31015462 31451708 29779033 29124443 30604766) Estimated glomerular filtration rate in non-diabetics ( 31451708) Glomerular filtration rate ( 27588450 29403010) Glomerular filtration rate (creatinine) ( 28452372 26831199) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Hyperuricemia ( 29124443) Macular thickness ( 30535121) Optic disc size ( 31809533) Proteinuria ( 30476138) Proteinuria (mild) ( 30476138) Proteinuria (moderate to severe) ( 30476138) Relapse in multiple sclerosis ( 28739605) Serum creatinine levels ( 29779033) Serum uric acid levels ( 30993211 29124443 29403010) Urate levels ( 31578528 20139978)
Interacting Genes		8 interacting genes: CHP1 CHP2 LRP2 MAST2 PDZK1 SHANK2 SLC9A3R1 SLC9A3R2	51 interacting genes: ALB ANAPC10 ANKRA2 ANKS1B APBA2 APBB1 APOB APOE APOH APP ATN1 CDC42 CLU CUBN DAB1 DAB2 DLG1 DLG2 DLG3 DLG4 GC GIPC1 GPRASP1 INS ITGB1BP1 LCN2 LDLRAP1 LPA LPL LRP2BP LRPAP1 MAGI1 MAPK8IP1 MAPK8IP2 MDK NOS1AP PIP5K1C PLAU RAC1 RBP1 RHOA SCGB1A1 SCN3A SERPINE1 SLC9A3 SNX17 SYNJ2BP TG THBS1 TLN1 TTR
Entrez ID		6550	4036
HPRD ID		01660	02509
Ensembl ID		ENSG00000066230	ENSG00000081479
Uniprot IDs		P48764	P98164 Q7Z5C0 Q7Z5C1
PDB IDs			2M0P
Enriched GO Terms of Interacting Partners?
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