SHANK2 and SSTR2

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		SHANK2	SSTR2
Description		SH3 and multiple ankyrin repeat domains 2	somatostatin receptor 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Photoreceptor Outer Segment Photoreceptor Inner Segment Cellular_component Cytosol Neurofilament Plasma Membrane Ionotropic Glutamate Receptor Complex Postsynaptic Density Apical Plasma Membrane Growth Cone Brush Border Membrane Neuron Projection Neuronal Cell Body Dendritic Spine Postsynaptic Membrane Ciliary Membrane	Cytosol Plasma Membrane Integral Component Of Plasma Membrane Neuron Projection
	Molecular Function	Protein Binding SH3 Domain Binding Synaptic Receptor Adaptor Activity Ionotropic Glutamate Receptor Binding	G Protein-coupled Receptor Activity Somatostatin Receptor Activity Protein Binding PDZ Domain Binding Peptide Binding Neuropeptide Binding
	Biological Process	Synapse Assembly Behavior Learning Positive Regulation Of Cell Population Proliferation Adult Behavior Social Behavior Negative Regulation Of Hippo Signaling Brain Morphogenesis Synaptic Growth At Neuromuscular Junction Positive Regulation Of Synaptic Transmission, Glutamatergic Long-term Synaptic Potentiation Long-term Synaptic Depression Dendritic Spine Morphogenesis Positive Regulation Of Dendritic Spine Development Vocalization Behavior Postsynaptic Density Assembly Regulation Of AMPA Receptor Activity Positive Regulation Of Excitatory Postsynaptic Potential	Regulation Of Muscle Contraction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Spermatogenesis Negative Regulation Of Cell Population Proliferation Cerebellum Development Peristalsis Forebrain Development Somatostatin Signaling Pathway Response To Starvation Cellular Response To Glucocorticoid Stimulus Cellular Response To Estradiol Stimulus
Pathways		Neurexins and neuroligins Neurexins and neuroligins	Peptide ligand-binding receptors G alpha (i) signalling events
Drugs			Vapreotide Pasireotide Lanreotide Somatostatin Dotatate gallium Ga-68 Lutetium Lu 177 dotatate Edotreotide gallium Ga-68 Copper oxodotreotide Cu-64
Diseases
GWAS		Bipolar disorder ( 31043756) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Hip circumference ( 28552196) Late-onset Alzheimer's disease ( 27770636) Obesity-related traits ( 23251661) Response to fenofibrate (adiponectin levels) ( 23149075) Urate levels in obese individuals ( 25811787)	Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678) Metabolite levels ( 23823483)
Interacting Genes		19 interacting genes: ADGRB2 ADGRL1 ADGRL2 ARHGAP12 ARHGEF7 BAIAP2 CTTN DLG4 DLGAP1 DLGAP2 DLGAP3 DLGAP4 DNM2 HOMER1 PPP3CA RIPOR3 SHARPIN SLC9A3 SSTR2	10 interacting genes: APP CORT DRD2 GNA14 GNAI1 PIK3R1 PTPN6 SHANK1 SHANK2 SST
Entrez ID		22941	6752
HPRD ID		04479	01674
Ensembl ID		ENSG00000162105	ENSG00000180616
Uniprot IDs		A0A590UJ45 A6NHU9 C0SPH0 Q9UPX8	P30874
PDB IDs
Enriched GO Terms of Interacting Partners?
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