SHANK2 and SHARPIN

Data Source:
BioGRID (unspecified method)

		SHANK2	SHARPIN
Description		SH3 and multiple ankyrin repeat domains 2	SHANK associated RH domain interactor
Image		No pdb structure
GO Annotations	Cellular Component	Photoreceptor Outer Segment Photoreceptor Inner Segment Cellular_component Cytosol Neurofilament Plasma Membrane Ionotropic Glutamate Receptor Complex Postsynaptic Density Apical Plasma Membrane Growth Cone Brush Border Membrane Neuron Projection Neuronal Cell Body Dendritic Spine Postsynaptic Membrane Ciliary Membrane	Ubiquitin Ligase Complex Cytosol Postsynaptic Density Dendrite LUBAC Complex
	Molecular Function	Protein Binding SH3 Domain Binding Synaptic Receptor Adaptor Activity Ionotropic Glutamate Receptor Binding	Ubiquitin-protein Transferase Activity Protein Binding Polyubiquitin Modification-dependent Protein Binding Identical Protein Binding Ubiquitin Binding Protein-containing Complex Binding Metal Ion Binding
	Biological Process	Synapse Assembly Behavior Learning Positive Regulation Of Cell Population Proliferation Adult Behavior Social Behavior Negative Regulation Of Hippo Signaling Brain Morphogenesis Synaptic Growth At Neuromuscular Junction Positive Regulation Of Synaptic Transmission, Glutamatergic Long-term Synaptic Potentiation Long-term Synaptic Depression Dendritic Spine Morphogenesis Positive Regulation Of Dendritic Spine Development Vocalization Behavior Postsynaptic Density Assembly Regulation Of AMPA Receptor Activity Positive Regulation Of Excitatory Postsynaptic Potential	Mitochondrion Organization I-kappaB Kinase/NF-kappaB Signaling Brain Development Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Apoptotic Nuclear Changes Keratinization Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Inflammatory Response Protein Linear Polyubiquitination Regulation Of CD40 Signaling Pathway
Pathways		Neurexins and neuroligins Neurexins and neuroligins	Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway Neurexins and neuroligins
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Hip circumference ( 28552196) Late-onset Alzheimer's disease ( 27770636) Obesity-related traits ( 23251661) Response to fenofibrate (adiponectin levels) ( 23149075) Urate levels in obese individuals ( 25811787)	Asthma ( 31959851 32296059) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Neutrophil percentage of granulocytes ( 27863252) Serum metabolite levels ( 23093944) Sum eosinophil basophil counts ( 27863252)
Interacting Genes		19 interacting genes: ADGRB2 ADGRL1 ADGRL2 ARHGAP12 ARHGEF7 BAIAP2 CTTN DLG4 DLGAP1 DLGAP2 DLGAP3 DLGAP4 DNM2 HOMER1 PPP3CA RIPOR3 SHARPIN SLC9A3 SSTR2	21 interacting genes: ACTR2 ACTR3 ITGA1 ITGA2B ITGA5 ITGAD ITGAL ITGAM ITGB2 KRTAP6-2 KRTAP7-1 PPIL3 SHANK1 SHANK2 TRAF1 TRIP13 TXN2 UBC USP54 YOD1 ZBTB32
Entrez ID		22941	81858
HPRD ID		04479	15463
Ensembl ID		ENSG00000162105	ENSG00000179526
Uniprot IDs		A0A590UJ45 A6NHU9 C0SPH0 Q9UPX8	Q6PJD5 Q9H0F6
PDB IDs			4EMO 5X0W
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?