SHANK2 and ADGRL2

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		SHANK2	ADGRL2
Description		SH3 and multiple ankyrin repeat domains 2	adhesion G protein-coupled receptor L2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Photoreceptor Outer Segment Photoreceptor Inner Segment Cellular_component Cytosol Neurofilament Plasma Membrane Ionotropic Glutamate Receptor Complex Postsynaptic Density Apical Plasma Membrane Growth Cone Brush Border Membrane Neuron Projection Neuronal Cell Body Dendritic Spine Postsynaptic Membrane Ciliary Membrane	Integral Component Of Plasma Membrane Integral Component Of Membrane Neuron Projection Glutamatergic Synapse Integral Component Of Postsynaptic Membrane
	Molecular Function	Protein Binding SH3 Domain Binding Synaptic Receptor Adaptor Activity Ionotropic Glutamate Receptor Binding	G Protein-coupled Receptor Activity Latrotoxin Receptor Activity Carbohydrate Binding
	Biological Process	Synapse Assembly Behavior Learning Positive Regulation Of Cell Population Proliferation Adult Behavior Social Behavior Negative Regulation Of Hippo Signaling Brain Morphogenesis Synaptic Growth At Neuromuscular Junction Positive Regulation Of Synaptic Transmission, Glutamatergic Long-term Synaptic Potentiation Long-term Synaptic Depression Dendritic Spine Morphogenesis Positive Regulation Of Dendritic Spine Development Vocalization Behavior Postsynaptic Density Assembly Regulation Of AMPA Receptor Activity Positive Regulation Of Excitatory Postsynaptic Potential	Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Brain Development Response To Bacterium Synapse Organization Positive Regulation Of Synapse Assembly
Pathways		Neurexins and neuroligins Neurexins and neuroligins
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Hip circumference ( 28552196) Late-onset Alzheimer's disease ( 27770636) Obesity-related traits ( 23251661) Response to fenofibrate (adiponectin levels) ( 23149075) Urate levels in obese individuals ( 25811787)	Clozapine-induced agranulocytosis/granulocytopenia in treatment-resistant schizophrenia ( 27400856) Estimated glomerular filtration rate after 5 years in renal transplantation (recipient effect) ( 30920136) Impaired insulin sensitivity in response to n-3 PUFA supplementation ( 31779001) Low density lipoprotein cholesterol levels ( 30498476)
Interacting Genes		19 interacting genes: ADGRB2 ADGRL1 ADGRL2 ARHGAP12 ARHGEF7 BAIAP2 CTTN DLG4 DLGAP1 DLGAP2 DLGAP3 DLGAP4 DNM2 HOMER1 PPP3CA RIPOR3 SHARPIN SLC9A3 SSTR2	3 interacting genes: NCK1 SHANK1 SHANK2
Entrez ID		22941	23266
HPRD ID		04479	06116
Ensembl ID		ENSG00000162105	ENSG00000117114
Uniprot IDs		A0A590UJ45 A6NHU9 C0SPH0 Q9UPX8	A0A6I8PTT2 O95490
PDB IDs
Enriched GO Terms of Interacting Partners?
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