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NCF1 and PRKCD
Data Source:
BioGRID
(enzymatic study)
NCF1
PRKCD
Description
neutrophil cytosolic factor 1
protein kinase C delta
Image
GO Annotations
Cellular Component
Cytoplasm
Rough Endoplasmic Reticulum
Golgi Apparatus
Cytosol
Plasma Membrane
Membrane
Extrinsic Component Of Membrane
Dendrite
Phagolysosome
NADPH Oxidase Complex
Neuronal Cell Body
Extracellular Region
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Endoplasmic Reticulum
Cytosol
Plasma Membrane
Cell-cell Junction
Nuclear Matrix
Azurophil Granule Lumen
Endolysosome
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Molecular Function
Protein Binding
Electron Transfer Activity
Superoxide-generating NAD(P)H Oxidase Activity
Superoxide-generating NADPH Oxidase Activator Activity
SH3 Domain Binding
Phosphatidylinositol Binding
Phosphatidylinositol-3,4-bisphosphate Binding
Molecular Adaptor Activity
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Kinase C Activity
Calcium-dependent Protein Kinase C Activity
Calcium-independent Protein Kinase C Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Protein Binding
ATP Binding
Enzyme Activator Activity
Enzyme Binding
Kinase Binding
Protein Kinase Binding
Insulin Receptor Substrate Binding
Metal Ion Binding
Protein Serine Kinase Activity
Biological Process
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
Protein Targeting To Membrane
Superoxide Metabolic Process
Apoptotic Process
Cellular Defense Response
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Electron Transport Chain
Cellular Response To Oxidative Stress
Cellular Response To Reactive Oxygen Species
Superoxide Anion Generation
Innate Immune Response
Cell Redox Homeostasis
Respiratory Burst
Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of JNK Cascade
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Cellular Response To Cadmium Ion
Positive Regulation Of P38MAPK Cascade
Stimulatory C-type Lectin Receptor Signaling Pathway
Protein Phosphorylation
Apoptotic Process
Cell Cycle
Signal Transduction
Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress
Regulation Of Signaling Receptor Activity
Immunoglobulin Mediated Immune Response
Histone Phosphorylation
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Peptidyl-tyrosine Phosphorylation
Termination Of Signal Transduction
Platelet Activation
Negative Regulation Of Actin Filament Polymerization
Positive Regulation Of Endodeoxyribonuclease Activity
Negative Regulation Of Protein Binding
Activation Of Protein Kinase Activity
Positive Regulation Of Superoxide Anion Generation
Regulation Of Actin Cytoskeleton Organization
Negative Regulation Of Glial Cell Apoptotic Process
Cellular Response To UV
Positive Regulation Of Protein Dephosphorylation
Intracellular Signal Transduction
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
B Cell Proliferation
Neutrophil Activation
Positive Regulation Of Protein Import Into Nucleus
Defense Response To Bacterium
Neutrophil Degranulation
Negative Regulation Of MAP Kinase Activity
Regulation Of MRNA Stability
Negative Regulation Of Insulin Receptor Signaling Pathway
Negative Regulation Of Inflammatory Response
Negative Regulation Of Peptidyl-tyrosine Phosphorylation
Protein Stabilization
Negative Regulation Of Filopodium Assembly
Cell Chemotaxis
Interferon-gamma-mediated Signaling Pathway
Cellular Response To Hydrogen Peroxide
Cellular Response To Hydroperoxide
Negative Regulation Of Platelet Aggregation
Cellular Senescence
Positive Regulation Of Phospholipid Scramblase Activity
Cellular Response To Angiotensin
Regulation Of Ceramide Biosynthetic Process
Positive Regulation Of Ceramide Biosynthetic Process
Positive Regulation Of Glucosylceramide Catabolic Process
Positive Regulation Of Sphingomyelin Catabolic Process
Positive Regulation Of Response To DNA Damage Stimulus
Positive Regulation Of Apoptotic Signaling Pathway
Pathways
ROS and RNS production in phagocytes
Cross-presentation of particulate exogenous antigens (phagosomes)
Detoxification of Reactive Oxygen Species
VEGFA-VEGFR2 Pathway
RHO GTPases Activate NADPH Oxidases
Apoptotic cleavage of cellular proteins
Calmodulin induced events
Effects of PIP2 hydrolysis
SHC1 events in ERBB2 signaling
DAG and IP3 signaling
Role of phospholipids in phagocytosis
G alpha (z) signalling events
HuR (ELAVL1) binds and stabilizes mRNA
VEGFR2 mediated cell proliferation
CLEC7A (Dectin-1) signaling
RHO GTPases Activate NADPH Oxidases
Neutrophil degranulation
Interferon gamma signaling
Drugs
Dextromethorphan
Tamoxifen
13-Acetylphorbol
Ingenol mebutate
Fostamatinib
Diseases
Chronic granulomatous disease, including the following four diseases: X-linked CGD (gp91 phox CGD); p22phox deficiency (p22phox CGD); p47phox deficiency (p47phox CGD); p67phox deficiency (p67phox CGD)
GWAS
Bipolar disorder (
21926972
)
Disrupted circadian rhythm (low relative amplitude of rest-activity cycles) (
30120083
)
Ulcerative colitis (
23128233
)
Waist circumference adjusted for body mass index (
28552196
)
Interacting Genes
28 interacting genes:
ACTB
CSNK2B
CYBA
FASLG
GAA
GMNN
KHDRBS1
MAPK9
MGAM
MSN
MYBPC1
MYBPC3
NCF2
NCF4
NOXA1
PKD1
PLA2G4A
PRKCA
PRKCB
PRKCD
PRKCZ
PRKDC
PTEN
SH3RF1
SRSF2
SYTL1
TRAF4
TRIM9
120 interacting genes:
ACTA1
ACTA2
ACTB
ADAM9
ADCY7
ADD1
ADD2
ADRA2A
ADRB2
AFAP1
AKT3
APP
ART3
BDKRB2
C1QBP
CD34
CDCP1
CHAT
CNP
CREBBP
CYTH1
DAB2
DYNC1H1
EEF1A1
EGFR
EIF2S1
ELAVL1
EP300
ESRRA
FLI1
FSCN1
FYN
GABRA1
GAP43
GNA12
GNA13
GNAZ
GRK2
GRM5
GSK3A
H1-1
H1-5
HABP4
HDAC5
HNRNPK
HSP90AA1
HSPA4
IGF1R
IKBKB
IL6ST
INSR
IRS1
ITGA6
ITGB2
ITGB4
ITGB7
ITPR1
KCNJ1
KCNJ4
KLF5
LCK
LMNB1
LMNB2
LYN
MACF1
MAPK1
MAPK3
MAPT
MBP
MEP1B
MS4A2
MUC1
NCF1
NCF4
NFE2L2
NOTCH1
NUMB
OPRD1
PAK1
PDP1
PDP2
PDPK1
PEBP1
PIK3CA
PIK3CB
PLCB1
PLD2
PLSCR1
PLSCR3
PPARA
PPM1A
PPP1CA
PPP2CA
PPP2R5C
PRKCZ
PRKDC
PTK2B
PTPN22
PTPN6
PTPRA
RAC1
RACK1
RAF1
RASGRP3
RIPK4
RUNX2
SDC4
SHC1
SPRY2
SQSTM1
SRC
STAT1
STAT3
TAGLN
TIAM1
TNFRSF1A
VCP
YWHAB
YWHAG
YWHAZ
Entrez ID
653361
5580
HPRD ID
01501
Ensembl ID
ENSG00000158517
ENSG00000163932
Uniprot IDs
P14598
A0A024R328
B4DFV1
Q05655
PDB IDs
1GD5
1K4U
1KQ6
1NG2
1O7K
1OV3
1UEC
1W70
1WLP
1YRK
2YUU
Enriched GO Terms of Interacting Partners
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