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NCF1 and CSNK2B
Data Source:
BioGRID
(two hybrid)
NCF1
CSNK2B
Description
neutrophil cytosolic factor 1
casein kinase 2 beta
Image
GO Annotations
Cellular Component
Cytoplasm
Rough Endoplasmic Reticulum
Golgi Apparatus
Cytosol
Plasma Membrane
Membrane
Extrinsic Component Of Membrane
Dendrite
Phagolysosome
NADPH Oxidase Complex
Neuronal Cell Body
Extracellular Region
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Plasma Membrane
Protein Kinase CK2 Complex
PcG Protein Complex
Secretory Granule Lumen
Extracellular Exosome
Ficolin-1-rich Granule Lumen
Molecular Function
Protein Binding
Electron Transfer Activity
Superoxide-generating NAD(P)H Oxidase Activity
Superoxide-generating NADPH Oxidase Activator Activity
SH3 Domain Binding
Phosphatidylinositol Binding
Phosphatidylinositol-3,4-bisphosphate Binding
Molecular Adaptor Activity
Chromatin Binding
Protein Serine/threonine Kinase Activity
Signaling Receptor Binding
Protein Binding
Transcription Factor Binding
Protein Kinase Regulator Activity
Protein Domain Specific Binding
Identical Protein Binding
Metal Ion Binding
Biological Process
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
Protein Targeting To Membrane
Superoxide Metabolic Process
Apoptotic Process
Cellular Defense Response
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Electron Transport Chain
Cellular Response To Oxidative Stress
Cellular Response To Reactive Oxygen Species
Superoxide Anion Generation
Innate Immune Response
Cell Redox Homeostasis
Respiratory Burst
Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of JNK Cascade
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Cellular Response To Cadmium Ion
Positive Regulation Of P38MAPK Cascade
Protein Folding
Phosphatidylcholine Biosynthetic Process
Signal Transduction
Negative Regulation Of Cell Population Proliferation
Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation
Wnt Signaling Pathway
Macroautophagy
Peptidyl-threonine Phosphorylation
Positive Regulation Of Activin Receptor Signaling Pathway
Adiponectin-activated Signaling Pathway
Cellular Protein-containing Complex Assembly
Neutrophil Degranulation
Negative Regulation Of Blood Vessel Endothelial Cell Migration
Regulation Of Protein Kinase Activity
Regulation Of DNA Binding
Endothelial Tube Morphogenesis
Regulation Of Signal Transduction By P53 Class Mediator
Pathways
ROS and RNS production in phagocytes
Cross-presentation of particulate exogenous antigens (phagosomes)
Detoxification of Reactive Oxygen Species
VEGFA-VEGFR2 Pathway
RHO GTPases Activate NADPH Oxidases
Synthesis of PC
WNT mediated activation of DVL
Condensation of Prometaphase Chromosomes
Signal transduction by L1
Neutrophil degranulation
Regulation of TP53 Activity through Phosphorylation
Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
Receptor Mediated Mitophagy
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
Regulation of PTEN stability and activity
Drugs
Dextromethorphan
ATP
Quercetin
Diseases
Chronic granulomatous disease, including the following four diseases: X-linked CGD (gp91 phox CGD); p22phox deficiency (p22phox CGD); p47phox deficiency (p47phox CGD); p67phox deficiency (p67phox CGD)
GWAS
Asthma (
31619474
)
Asthma (childhood onset) (
31619474
)
Asthma and major depressive disorder (
31619474
)
Autism spectrum disorder or schizophrenia (
28540026
)
Blood protein levels (
28240269
)
Cutaneous lupus erythematosus (
25827949
)
Inflammatory bowel disease (
28067908
)
Malaria (
31844061
)
Systemic lupus erythematosus (
26316170
)
Ulcerative colitis (
28067908
)
Interacting Genes
28 interacting genes:
ACTB
CSNK2B
CYBA
FASLG
GAA
GMNN
KHDRBS1
MAPK9
MGAM
MSN
MYBPC1
MYBPC3
NCF2
NCF4
NOXA1
PKD1
PLA2G4A
PRKCA
PRKCB
PRKCD
PRKCZ
PRKDC
PTEN
SH3RF1
SRSF2
SYTL1
TRAF4
TRIM9
223 interacting genes:
ABHD4
ACTB
ACTL6B
ACTR1B
ACTR5
ACVRL1
ADD1
ADH5
ANGPT2
ANKRD28
AP2M1
APLP1
ARAF
ATF1
ATG101
ATXN3
BAG6
BANP
BCCIP
BHLHE41
BID
BMI1
BRCA1
BTF3
C6orf136
CACNA1A
CALM1
CBX4
CCDC115
CCDC187
CCNH
CD163
CD81
CDC25B
CDC34
CDK1
CDK20
CDKN1A
CENPB
CHEK1
CHRNA4
CIC
CIPC
CLOCK
COIL
COL4A2
COPS3
COPS7A
CPNE7
CSN1S1
CSN2
CSNK1E
CSNK2A1
CSNK2A2
CST1
CTDP1
CTNNB1
DACT1
DALRD3
DELEC1
DENND5A
DNMT1
DPF3
DUX1
DYNLT2B
EIF2S2
EIF5
EIF6
EPS8
ERCC6
ERCC8
ESR1
FAF1
FAM86C1P
FBXL15
FBXL5
FGB
FGF1
FGF2
FIBP
FKBP3
FTH1
GADD45GIP1
GAMT
GBP2
GLB1
GLIS2
GNB5
GRK2
GSK3B
HEXB
HIRIP3
HNRNPA2B1
HOXB5
HOXB6
HTRA1
HYPK
IER3IP1
INO80B
INTS11
IRS1
ITSN1
KDM6B
KIF2C
LCK
LEPR
LMO4
LRP5L
LTB4R2
LYN
LYST
MAPK14
MBD4
MDM2
MME
MOXD1
MPP2
NAP1L1
NCF1
NGDN
NMT2
NOLC1
NOTCH3
NPAS2
NRBP1
NRF1
NTAQ1
ODC1
OGA
OGT
PDS5A
PER1
PER2
PFKFB4
PHC2
PHF11
PHRF1
PIMREG
PIN1
PITPNA
PLXNA3
POT1
PPID
PPP1CA
PPP1CB
PPP1CC
PPP2CA
PPP2R1A
PPP2R1B
PPP2R5D
PPP2R5E
PPP3CC
PRKAB2
PRKCZ
PRNP
PROC
PTPRK
PTTG2
PYROXD2
RAD51
RBM39
RFC1
RNF126
RNF7
RORB
RPA1
RPL13
RPL41
RPL5
RPS6KA5
RPS6KB1
RPS6KB2
RRAD
RXRA
SARNP
SDHA
SEC11A
SELENOI
SHANK3
SHMT1
SHMT2
SIMC1
SIRT1
SNX2
SPOUT1
SPSB3
SSB
STAT5A
STAU1
STK16
SUMO2
SYNE4
TCEAL7
TENM1
TFAP2A
TFAP2D
TLE1
TLX3
TNFAIP1
TOP2B
TP53
TP53BP2
TP63
TRIM54
TSEN54
TUBB2B
TWF1
UBE2I
UPF1
USO1
UTP14A
VDAC1
VRK3
WDR1
WDR18
WFIKKN1
WWOX
ZNF19
ZNF410
ZNF44
ZNF71
ZNF784
ZNHIT1
Entrez ID
653361
1460
HPRD ID
00278
Ensembl ID
ENSG00000158517
ENSG00000204435
Uniprot IDs
P14598
A0A1U9X7J2
N0E4C7
P67870
PDB IDs
1GD5
1K4U
1KQ6
1NG2
1O7K
1OV3
1UEC
1W70
1WLP
1DS5
1JWH
1QF8
3EED
4DGL
4MD7
4MD8
4MD9
4NH1
6Q38
Enriched GO Terms of Interacting Partners
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