KLC2 and DDX41

Data Source:
BioGRID (two hybrid)

		KLC2	DDX41
Description		kinesin light chain 2	DEAD-box helicase 41
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GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Cytosol Kinesin Complex Microtubule Plasma Membrane Membrane Kinesin I Complex Protein-containing Complex	Nucleus Spliceosomal Complex Cytosol Membrane Catalytic Step 2 Spliceosome
	Molecular Function	Protein Binding Kinesin Binding Cadherin Binding	RNA Binding RNA Helicase Activity Protein Binding ATP Binding Metal Ion Binding
	Biological Process	Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Microtubule-based Movement Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II	MRNA Splicing, Via Spliceosome Apoptotic Process Cell Population Proliferation Cell Differentiation Positive Regulation Of Type I Interferon Production
Pathways		MHC class II antigen presentation RHO GTPases activate KTN1 COPI-dependent Golgi-to-ER retrograde traffic Kinesins	STING mediated induction of host immune responses Regulation of innate immune responses to cytosolic DNA IRF3-mediated induction of type I IFN
Drugs
Diseases
GWAS		Bipolar disorder ( 21926972 31043756) Metabolite levels ( 23823483)	Coronary artery disease ( 29212778) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		16 interacting genes: AIMP2 APP CLSTN1 COIL DDX41 KIF2A KLC1 KLC4 LRRK2 MAPK8IP3 PIK3R3 PRC1 S100A8 YWHAG YWHAQ YWHAZ	7 interacting genes: AIDA CEP70 CHAF1A KLC2 NKAPL SIAH1 TUBG1
Entrez ID		64837	51428
HPRD ID		13917	10490
Ensembl ID		ENSG00000174996	ENSG00000183258
Uniprot IDs		Q9H0B6	B3KRK2 Q9UJV9
PDB IDs		3CEQ 3EDT	2P6N 5GVR 5GVS 5H1Y
Enriched GO Terms of Interacting Partners?
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