MICAL1 and RAB1B

Data Source:
HPRD (two hybrid)

		MICAL1	RAB1B
Description		microtubule associated monooxygenase, calponin and LIM domain containing 1	RAB1B, member RAS oncogene family
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GO Annotations	Cellular Component	Cytoplasm Cytosol Intermediate Filament Plasma Membrane Actin Cytoskeleton Midbody Intercellular Bridge Hippocampal Mossy Fiber Expansion	Golgi Membrane Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Endomembrane System Transport Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Phagophore Assembly Site Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Actin Binding Protein Binding NAD(P)H Oxidase H2O2-forming Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, NAD(P)H As One Donor, And Incorporation Of One Atom Of Oxygen SH3 Domain Binding Protein Kinase Binding Small GTPase Binding Metal Ion Binding Actin Filament Binding FAD Binding	GTPase Activity Protein Binding GTP Binding
	Biological Process	Negative Regulation Of Protein Phosphorylation Cytoskeleton Organization Signal Transduction Blood Coagulation Sulfur Oxidation Actin Filament Depolymerization Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Actin Filament Bundle Assembly Regulation Of Regulated Secretory Pathway	Autophagosome Assembly Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Virion Assembly Post-translational Protein Modification COPII Vesicle Coating Establishment Of Endothelial Intestinal Barrier Positive Regulation Of Glycoprotein Metabolic Process Regulation Of Autophagosome Assembly
Pathways		Factors involved in megakaryocyte development and platelet production	Golgi Cisternae Pericentriolar Stack Reorganization Golgi Cisternae Pericentriolar Stack Reorganization COPII-mediated vesicle transport COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases
GWAS		Depression in smokers ( 30219690) Height ( 28552196)	Bipolar disorder ( 21926972 31043756)
Interacting Genes		16 interacting genes: ABL1 CRK EHD1 GADD45A GRB2 GSK3B NEDD9 PIK3R3 PTK2 RAB10 RAB1A RAB1B RPS6KA6 SRC TAB1 VIM	11 interacting genes: APP CHM GDI1 GOLGA2 MICAL1 MICAL3 MICALCL RABIF RUSC2 SMARCC2 TOMM40L
Entrez ID		64780	81876
HPRD ID		06183	11469
Ensembl ID		ENSG00000135596	ENSG00000174903
Uniprot IDs		Q8TDZ2	Q9H0U4
PDB IDs		1WYL 2CO8 2DK9 5LE0 5LPN 6KU0	3JZA 3NKV 4HLQ 4I1O 5O74 5SZH 5SZK 6SKU
Enriched GO Terms of Interacting Partners?
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