MICAL1 and GADD45A

Data Source:
BioGRID (two hybrid)

		MICAL1	GADD45A
Description		microtubule associated monooxygenase, calponin and LIM domain containing 1	growth arrest and DNA damage inducible alpha
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GO Annotations	Cellular Component	Cytoplasm Cytosol Intermediate Filament Plasma Membrane Actin Cytoskeleton Midbody Intercellular Bridge Hippocampal Mossy Fiber Expansion	Nucleus Nucleoplasm Cytoplasm Nuclear Speck
	Molecular Function	Actin Binding Protein Binding NAD(P)H Oxidase H2O2-forming Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, NAD(P)H As One Donor, And Incorporation Of One Atom Of Oxygen SH3 Domain Binding Protein Kinase Binding Small GTPase Binding Metal Ion Binding Actin Filament Binding FAD Binding	Protein Binding Kinase Binding Protein Homodimerization Activity Protein Heterodimerization Activity Protein N-terminus Binding Promoter-specific Chromatin Binding
	Biological Process	Negative Regulation Of Protein Phosphorylation Cytoskeleton Organization Signal Transduction Blood Coagulation Sulfur Oxidation Actin Filament Depolymerization Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Actin Filament Bundle Assembly Regulation Of Regulated Secretory Pathway	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Transcription By RNA Polymerase II Activation Of MAPKKK Activity DNA Repair Apoptotic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Cell Cycle Arrest Centrosome Cycle Negative Regulation Of Angiogenesis Negative Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Signal Transduction In Response To DNA Damage Positive Regulation Of Apoptotic Process Negative Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of JNK Cascade Regulation Of Cell Cycle Cellular Response To Mechanical Stimulus Cellular Response To Ionizing Radiation Mitotic Cell Cycle Arrest Negative Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of P38MAPK Cascade Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Factors involved in megakaryocyte development and platelet production	TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest FOXO-mediated transcription of cell cycle genes
Drugs
Diseases
GWAS		Depression in smokers ( 30219690) Height ( 28552196)	Bone mineral density (hip) ( 30172743) Mean corpuscular volume ( 29403010) Offspring birth weight ( 31043758) Optic disc area ( 28073927) Optic disc size ( 31809533) Platelet distribution width ( 32888494) Red blood cell count ( 32888494)
Interacting Genes		16 interacting genes: ABL1 CRK EHD1 GADD45A GRB2 GSK3B NEDD9 PIK3R3 PTK2 RAB10 RAB1A RAB1B RPS6KA6 SRC TAB1 VIM	69 interacting genes: ADAP1 ASCC2 AURKA BAG6 CBY2 CCNB1 CDK1 CDK11A CDKN1A CENPB CHD3 CLEC3B CNOT9 DCTN2 DNAJC13 EEF1A1 EEF1G ERG28 FAM83D FAS FBN3 FTL GADD45GIP1 GAPDH GBP2 GNB2 H1-1 H2AC16 H2BC21 H3-4 H4-16 IGHM IGSF21 JMJD1C KHSRP LMO4 LNX2 MAP3K4 MAPK14 MASP1 MDM2 MICAL1 MIDN MPP1 NPM1 NRBP1 NUCB2 PARVG PCNA PFKFB4 PPARA PSMC3 PTN PTPRK QARS1 RAI1 RBPJ RPS2 RXRA SH3GLB1 SPTBN4 SYNE4 TLE1 TP53 UBE2D1 UBR1 VIM ZHX1 ZNF135
Entrez ID		64780	1647
HPRD ID		06183	00528
Ensembl ID		ENSG00000135596	ENSG00000116717
Uniprot IDs		Q8TDZ2	A5JUZ3 P24522
PDB IDs		1WYL 2CO8 2DK9 5LE0 5LPN 6KU0	2KG4
Enriched GO Terms of Interacting Partners?
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