SHB and LCP2

Data Source:
BioGRID (pull down)
HPRD (in vitro, in vivo)

		SHB	LCP2
Description		SH2 domain containing adaptor protein B	lymphocyte cytosolic protein 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytosol Plasma Membrane Cytoplasmic Ribonucleoprotein Granule	Cytosol Cell-cell Junction TCR Signalosome Plasma Membrane Raft
	Molecular Function	Phosphotyrosine Residue Binding Protein Binding	Protein Binding
	Biological Process	Angiogenesis Apoptotic Process Signal Transduction Cell Differentiation Vascular Endothelial Growth Factor Receptor Signaling Pathway	Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Platelet Activation Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway Mast Cell Activation Positive Regulation Of Protein Kinase Activity T Cell Receptor Signaling Pathway
Pathways		VEGFA-VEGFR2 Pathway VEGFA-VEGFR2 Pathway	GPVI-mediated activation cascade Generation of second messenger molecules Generation of second messenger molecules DAP12 signaling FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization
Drugs
Diseases
GWAS		Brain structure ( 20171287) Chronotype ( 30696823) Loneliness (linear analysis) ( 27629369) Metabolite levels (Dihydroxy docosatrienoic acid) ( 23934736) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878) Type 2 diabetes (age of onset) ( 28060188)	Acne (severe) ( 24927181) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Liver transplant-free survival in primary sclerosing cholangitis (time to event) ( 28779025) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814)
Interacting Genes		27 interacting genes: ABL1 AR CRK EGFR EPS8 ERBB2 ERBB3 ERBB4 GRAP2 GRB2 IL2RB IL2RG JAK1 JAK3 KDR KIT LAMTOR5 LAT LCP2 MET PDGFRA PIK3R1 PLCG1 SLC39A1 SRC VAV1 ZAP70	48 interacting genes: APP BLNK CBL CD22 CLNK EGFR ELOVL6 ERBB2 ERBB3 ERBB4 FXR2 FYB1 FYN GOLGA2 GRAP2 GRB2 HCK ITK LAT LCK LMNA LNX1 LYN MAP4K1 NCK1 NCK2 PAG1 PJA1 PLCG1 PLCG2 PRAM1 PTPN6 PTPRC SH3GL2 SH3RF1 SHB SHC1 STAM2 SYK TRAT1 TXK VAV1 VAV3 WAS YBX1 YWHAE YWHAZ ZAP70
Entrez ID		6461	3937
HPRD ID		02635	03362
Ensembl ID		ENSG00000107338	ENSG00000043462
Uniprot IDs		Q15464	Q13094
PDB IDs			1H3H 1YWO 2EAP 2ROR
Enriched GO Terms of Interacting Partners?
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