LCP2 and MAP4K1

Data Source:
HPRD (in vivo)

		LCP2	MAP4K1
Description		lymphocyte cytosolic protein 2	mitogen-activated protein kinase kinase kinase kinase 1
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GO Annotations	Cellular Component	Cytosol Cell-cell Junction TCR Signalosome Plasma Membrane Raft	Membrane
	Molecular Function	Protein Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding MAP Kinase Kinase Kinase Kinase Activity Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Platelet Activation Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway Mast Cell Activation Positive Regulation Of Protein Kinase Activity T Cell Receptor Signaling Pathway	Activation Of MAPKKK Activity Protein Phosphorylation Activation Of JUN Kinase Activity Cell Population Proliferation Peptidyl-serine Phosphorylation Protein Autophosphorylation Cellular Response To Phorbol 13-acetate 12-myristate
Pathways		GPVI-mediated activation cascade Generation of second messenger molecules Generation of second messenger molecules DAP12 signaling FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization
Drugs			Fostamatinib
Diseases
GWAS		Acne (severe) ( 24927181) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Liver transplant-free survival in primary sclerosing cholangitis (time to event) ( 28779025) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814)	Diisocyanate-induced asthma ( 25918132)
Interacting Genes		48 interacting genes: APP BLNK CBL CD22 CLNK EGFR ELOVL6 ERBB2 ERBB3 ERBB4 FXR2 FYB1 FYN GOLGA2 GRAP2 GRB2 HCK ITK LAT LCK LMNA LNX1 LYN MAP4K1 NCK1 NCK2 PAG1 PJA1 PLCG1 PLCG2 PRAM1 PTPN6 PTPRC SH3GL2 SH3RF1 SHB SHC1 STAM2 SYK TRAT1 TXK VAV1 VAV3 WAS YBX1 YWHAE YWHAZ ZAP70	22 interacting genes: ABL1 BLNK CARD11 CASP3 CRK CRKL DAPP1 DBNL EGFR GRAP2 GRB2 H2AC4 HCLS1 LAT LCP2 LYN MAP3K11 MAP3K7 NCK1 SHC1 SYK TMEM101
Entrez ID		3937	11184
HPRD ID		03362	03583
Ensembl ID		ENSG00000043462	ENSG00000104814
Uniprot IDs		Q13094	Q92918
PDB IDs		1H3H 1YWO 2EAP 2ROR	6CQD 6CQE 6CQF 6NFY 6NFZ 6NG0
Enriched GO Terms of Interacting Partners?
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