LCP2 and PAG1

Data Source:
HPRD (in vitro)

		LCP2	PAG1
Description		lymphocyte cytosolic protein 2	phosphoprotein membrane anchor with glycosphingolipid microdomains 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Cell-cell Junction TCR Signalosome Plasma Membrane Raft	Plasma Membrane Integral Component Of Membrane Membrane Raft
	Molecular Function	Protein Binding	Protein Binding Signaling Adaptor Activity SH2 Domain Binding
	Biological Process	Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Platelet Activation Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway Mast Cell Activation Positive Regulation Of Protein Kinase Activity T Cell Receptor Signaling Pathway	Adaptive Immune Response Signal Transduction Intracellular Signal Transduction T Cell Receptor Signaling Pathway Regulation Of T Cell Activation Negative Regulation Of T Cell Activation
Pathways		GPVI-mediated activation cascade Generation of second messenger molecules Generation of second messenger molecules DAP12 signaling FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization	GAB1 signalosome Phosphorylation of CD3 and TCR zeta chains
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Liver transplant-free survival in primary sclerosing cholangitis (time to event) ( 28779025) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814)	Glucocorticoid-induced osteonecrosis (age 10 years and older) ( 26265699) Health literacy ( 31250787) Serum total protein level ( 23022100)
Interacting Genes		48 interacting genes: APP BLNK CBL CD22 CLNK EGFR ELOVL6 ERBB2 ERBB3 ERBB4 FXR2 FYB1 FYN GOLGA2 GRAP2 GRB2 HCK ITK LAT LCK LMNA LNX1 LYN MAP4K1 NCK1 NCK2 PAG1 PJA1 PLCG1 PLCG2 PRAM1 PTPN6 PTPRC SH3GL2 SH3RF1 SHB SHC1 STAM2 SYK TRAT1 TXK VAV1 VAV3 WAS YBX1 YWHAE YWHAZ ZAP70	17 interacting genes: ABL1 CSK FYN GLS2 GRB2 HTRA2 LCK LCP2 LYN PTPN11 PTPN6 RASA1 SHC1 SLC9A3R1 SYK VAV1 ZAP70
Entrez ID		3937	55824
HPRD ID		03362	05772
Ensembl ID		ENSG00000043462	ENSG00000076641
Uniprot IDs		Q13094	Q9NWQ8
PDB IDs		1H3H 1YWO 2EAP 2ROR
Enriched GO Terms of Interacting Partners?
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