SHB and GRAP2

Data Source:
HPRD (in vitro)

		SHB	GRAP2
Description		SH2 domain containing adaptor protein B	GRB2 related adaptor protein 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytosol Plasma Membrane Cytoplasmic Ribonucleoprotein Granule	Nucleus Nucleoplasm Cytoplasm Endosome Cytosol Plasma Membrane
	Molecular Function	Phosphotyrosine Residue Binding Protein Binding	Protein Binding
	Biological Process	Angiogenesis Apoptotic Process Signal Transduction Cell Differentiation Vascular Endothelial Growth Factor Receptor Signaling Pathway	Ras Protein Signal Transduction Cell-cell Signaling T Cell Costimulation Fc-epsilon Receptor Signaling Pathway T Cell Receptor Signaling Pathway
Pathways		VEGFA-VEGFR2 Pathway VEGFA-VEGFR2 Pathway	Signaling by SCF-KIT Generation of second messenger molecules DAP12 signaling FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization CD28 co-stimulation FLT3 Signaling
Drugs
Diseases
GWAS		Brain structure ( 20171287) Chronotype ( 30696823) Loneliness (linear analysis) ( 27629369) Metabolite levels (Dihydroxy docosatrienoic acid) ( 23934736) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878) Type 2 diabetes (age of onset) ( 28060188)	Body mass index ( 26426971) Systemic lupus erythematosus ( 28714469)
Interacting Genes		27 interacting genes: ABL1 AR CRK EGFR EPS8 ERBB2 ERBB3 ERBB4 GRAP2 GRB2 IL2RB IL2RG JAK1 JAK3 KDR KIT LAMTOR5 LAT LCP2 MET PDGFRA PIK3R1 PLCG1 SLC39A1 SRC VAV1 ZAP70	79 interacting genes: AR BAG4 BEND5 BLNK CBL CBLB CBY2 CCHCR1 CCNDBP1 CD28 COG6 CSF1R DNM2 DVL2 EGFR ERBB2 ERBB3 ERBB4 ETV5 FASLG GAB1 GAB2 GAB3 GAREM1 GATA1 GFAP GOLGA2 GRB2 HNRNPK IHO1 IKZF3 KHDRBS1 KHDRBS2 KIT KPRP KRT13 KRTAP1-3 KRTAP4-11 KRTAP4-12 LAT LATS2 LAX1 LCP2 LNX1 LNX2 MAGED1 MAP4K1 MKRN3 MOS MTUS2 PBLD PNMA1 PRKAA2 PRPH2 PRR35 RACK1 RAVER1 RBPMS RIN3 RINT1 SH2D4A SHB SHC1 SOS2 SPRY2 SSX2IP STAMBP TFIP11 TLE5 TRAF1 TSNAXIP1 USP8 WWP2 YWHAE ZBTB7B ZNF250 ZNF319 ZNF526 ZSCAN21
Entrez ID		6461	9402
HPRD ID		02635	05156
Ensembl ID		ENSG00000107338	ENSG00000100351
Uniprot IDs		Q15464	B7Z8E3 O75791 Q6FI14
PDB IDs			5GJH
Enriched GO Terms of Interacting Partners?
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