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SHB and KDR
Data Source:
HPRD
(in vitro, in vivo)
SHB
KDR
Description
SH2 domain containing adaptor protein B
kinase insert domain receptor
Image
No pdb structure
GO Annotations
Cellular Component
Nucleoplasm
Cytosol
Plasma Membrane
Cytoplasmic Ribonucleoprotein Granule
Extracellular Region
Nucleus
Endosome
Early Endosome
Endoplasmic Reticulum
Golgi Apparatus
Plasma Membrane
Integral Component Of Plasma Membrane
Cell Junction
Receptor Complex
Membrane Raft
Sorting Endosome
Molecular Function
Phosphotyrosine Residue Binding
Protein Binding
Protein Tyrosine Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
Vascular Endothelial Growth Factor-activated Receptor Activity
Integrin Binding
Protein Binding
ATP Binding
Growth Factor Binding
Vascular Endothelial Growth Factor Binding
Identical Protein Binding
Cadherin Binding
Hsp90 Protein Binding
Biological Process
Angiogenesis
Apoptotic Process
Signal Transduction
Cell Differentiation
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Angiogenesis
Branching Involved In Blood Vessel Morphogenesis
Vasculogenesis
Positive Regulation Of Protein Phosphorylation
Positive Regulation Of Endothelial Cell Proliferation
Cell Migration Involved In Sprouting Angiogenesis
Hematopoietic Progenitor Cell Differentiation
Endothelium Development
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Multicellular Organism Development
Positive Regulation Of Cell Population Proliferation
Regulation Of Cell Shape
Positive Regulation Of Endothelial Cell Migration
Negative Regulation Of Gene Expression
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Viral Process
Positive Regulation Of Macroautophagy
Cell Migration
Peptidyl-tyrosine Phosphorylation
Extracellular Matrix Organization
Positive Regulation Of Cell Migration
Positive Regulation Of Kinase Activity
Embryonic Hemopoiesis
Calcium-mediated Signaling Using Intracellular Calcium Source
Cellular Response To Vascular Endothelial Growth Factor Stimulus
Vascular Endothelial Growth Factor Receptor-2 Signaling Pathway
Positive Regulation Of Endothelial Cell Chemotaxis By VEGF-activated Vascular Endothelial Growth Factor Receptor Signaling Pathway
Peptidyl-tyrosine Autophosphorylation
Vascular Endothelial Growth Factor Signaling Pathway
Negative Regulation Of Apoptotic Process
Positive Regulation Of MAPK Cascade
Protein Kinase B Signaling
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Endothelial Cell Differentiation
Positive Regulation Of Angiogenesis
Protein Autophosphorylation
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Positive Regulation Of Positive Chemotaxis
Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process
Positive Regulation Of Focal Adhesion Assembly
Positive Regulation Of Mitochondrial Depolarization
Vascular Wound Healing
ERK1 And ERK2 Cascade
Positive Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Positive Regulation Of Mitochondrial Fission
Cellular Response To Hydrogen Sulfide
Negative Regulation Of Endothelial Cell Apoptotic Process
Positive Regulation Of Vasculogenesis
Pathways
VEGFA-VEGFR2 Pathway
VEGFA-VEGFR2 Pathway
Neurophilin interactions with VEGF and VEGFR
VEGF binds to VEGFR leading to receptor dimerization
Integrin cell surface interactions
VEGFA-VEGFR2 Pathway
VEGFA-VEGFR2 Pathway
VEGFR2 mediated cell proliferation
Signaling by membrane-tethered fusions of PDGFRA or PDGFRB
Drugs
Sorafenib
Sunitinib
1-{4-[4-Amino-6-(4-methoxyphenyl)furo[2,3-d]pyrimidin-5-yl]phenyl}-3-[2-fluoro-5-(trifluoromethyl)phenyl]urea
Cediranib
Vatalanib
XL999
TG-100801
XL820
CYC116
Ramucirumab
Pegdinetanib
RAF-265
ABT-869
IMC-1C11
Semaxanib
Pazopanib
Midostaurin
Axitinib
4-[[2-[[4-chloro-3-(trifluoromethyl)phenyl]amino]-3H-benzimidazol-5-yl]oxy]-N-methyl-pyridine-2-carboxamide
N-(4-phenoxyphenyl)-2-[(pyridin-4-ylmethyl)amino]nicotinamide
N-cyclopropyl-6-[(6,7-dimethoxyquinolin-4-yl)oxy]naphthalene-1-carboxamide
6-chloro-N-pyrimidin-5-yl-3-{[3-(trifluoromethyl)phenyl]amino}-1,2-benzisoxazole-7-carboxamide
N-(CYCLOPROPYLMETHYL)-4-(METHYLOXY)-3-({5-[3-(3-PYRIDINYL)PHENYL]-1,3-OXAZOL-2-YL}AMINO)BENZENESULFONAMIDE
N-[5-(ETHYLSULFONYL)-2-METHOXYPHENYL]-5-[3-(2-PYRIDINYL)PHENYL]-1,3-OXAZOL-2-AMINE
3-(2-aminoquinazolin-6-yl)-1-(3,3-dimethylindolin-6-yl)-4-methylpyridin-2(1H)-one
3-(2-aminoquinazolin-6-yl)-4-methyl-1-[3-(trifluoromethyl)phenyl]pyridin-2(1H)-one
N'-(6-aminopyridin-3-yl)-N-(2-cyclopentylethyl)-4-methyl-benzene-1,3-dicarboxamide
N~4~-methyl-N~4~-(3-methyl-1H-indazol-6-yl)-N~2~-(3,4,5-trimethoxyphenyl)pyrimidine-2,4-diamine
N~4~-(3-methyl-1H-indazol-6-yl)-N~2~-(3,4,5-trimethoxyphenyl)pyrimidine-2,4-diamine
Cabozantinib
Regorafenib
Ponatinib
Lenvatinib
Nintedanib
Fostamatinib
Erdafitinib
Foretinib
Ripretinib
Pralsetinib
Diseases
GWAS
Brain structure (
20171287
)
Chronotype (
30696823
)
Loneliness (linear analysis) (
27629369
)
Metabolite levels (Dihydroxy docosatrienoic acid) (
23934736
)
Pulse pressure (
27841878
)
Systolic blood pressure (
27841878
)
Type 2 diabetes (age of onset) (
28060188
)
Blood protein levels (
30072576
29875488
28240269
)
Endometriosis (
28537267
)
FEV1 (
30804560
)
Heel bone mineral density (
30598549
)
Lung function (FVC) (
30804560
)
Mosquito bite size (
28199695
)
Peak expiratory flow (
30804560
)
Serum VEGFR2 concentration (
25411163
)
Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) (
26426971
)
Interacting Genes
27 interacting genes:
ABL1
AR
CRK
EGFR
EPS8
ERBB2
ERBB3
ERBB4
GRAP2
GRB2
IL2RB
IL2RG
JAK1
JAK3
KDR
KIT
LAMTOR5
LAT
LCP2
MET
PDGFRA
PIK3R1
PLCG1
SLC39A1
SRC
VAV1
ZAP70
60 interacting genes:
ACP1
AIMP2
ANXA5
ATR
BMX
BTRC
CAV1
CBL
CCDC88A
CDH5
COL18A1
CRK
CSF2RB
CSNK1D
CTNNB1
DNM2
DUSP19
FBXO25
FBXW11
FLT1
FLT4
FRS2
FYN
GABARAP
GNA11
GNAQ
GRB10
GRB2
HSP90AA1
ILKAP
IQGAP1
ITGB3
MAPK1
NCK1
NRP1
P2RY2
PDCL3
PLCG1
PLCG2
PPM1A
PPM1B
PTPN11
PTPN12
PTPN6
PTPRR
RASA1
SERPINF1
SH2D2A
SHB
SHC1
SHC2
SRC
STAT1
STYX
SYNGAP1
TIMP3
VEGFA
VEGFC
VEGFD
YES1
Entrez ID
6461
3791
HPRD ID
02635
01867
Ensembl ID
ENSG00000107338
ENSG00000128052
Uniprot IDs
Q15464
P35968
PDB IDs
1VR2
1Y6A
1Y6B
1YWN
2M59
2MET
2MEU
2OH4
2P2H
2P2I
2QU5
2QU6
2RL5
2X1W
2X1X
2XIR
3B8Q
3B8R
3BE2
3C7Q
3CJF
3CJG
3CP9
3CPB
3CPC
3DTW
3EFL
3EWH
3KVQ
3S35
3S36
3S37
3U6J
3V2A
3V6B
3VHE
3VHK
3VID
3VNT
3VO3
3WZD
3WZE
4AG8
4AGC
4AGD
4ASD
4ASE
5EW3
5OYJ
6GQO
6GQP
6GQQ
6XVJ
6XVK
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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