CLEC7A and RANBP9

Data Source:
BioGRID (two hybrid)

		CLEC7A	RANBP9
Description		C-type lectin domain containing 7A	RAN binding protein 9
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Cell Surface Integral Component Of Membrane	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Microtubule Associated Complex Plasma Membrane Nuclear Body
	Molecular Function	(1->3)-beta-D-glucan Binding Protein Binding Carbohydrate Binding Pattern Recognition Receptor Activity MHC Protein Binding Metal Ion Binding	Protein Binding Enzyme Binding
	Biological Process	Leukocyte Activation Involved In Immune Response Positive Regulation Of Dendritic Cell Cytokine Production Phagocytosis, Recognition Inflammatory Response Cell Recognition Positive Regulation Of Cell Population Proliferation Carbohydrate Mediated Signaling Positive Regulation Of Gene Expression Detection Of Fungus Positive Regulation Of Cell Migration Positive Regulation Of Protein-containing Complex Assembly Detection Of Molecule Of Fungal Origin Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Superoxide Anion Generation T Cell Activation Defense Response To Protozoan Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Innate Immune Response Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Phagocytosis Positive Regulation Of Lymphocyte Activation Positive Regulation Of Killing Of Cells Of Other Organism Positive Regulation Of Respiratory Burst Cellular Response To Molecule Of Fungal Origin Positive Regulation Of Monocyte Chemotactic Protein-1 Production Positive Regulation Of Wound Healing Positive Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Cell Maturation	MAPK Cascade Cytoskeleton Organization Microtubule Nucleation Cell Surface Receptor Signaling Pathway Axon Guidance Protein-containing Complex Assembly Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Amyloid Precursor Protein Catabolic Process
Pathways		CLEC7A (Dectin-1) signaling CLEC7A (Dectin-1) signaling	L1CAM interactions RAF/MAP kinase cascade MET activates RAS signaling
Drugs
Diseases		Chronic Mucocutaneous Candidiasis (CMC); Familial candidiasis (CANDF)
GWAS			Breast cancer ( 29059683 23535729)
Interacting Genes		47 interacting genes: ADAM33 AIP ARL13B ASGR2 BNIP3 BNIP3L C14orf180 CALM3 CD53 CD74 CTXN3 CXCL9 FAM3A FCGR1A FNDC9 GJB1 HSPD1 IFNGR2 IL1RL1 JAGN1 KLRC1 KTN1 MTIF3 NEMP1 NINJ2 NSG2 OCLN OLFM4 OPRM1 PTTG1IP RANBP9 RHOU SAR1A SEC22A SGCB SMIM3 SPINT1 SUSD3 SYNE4 TEX29 TLCD4 TMEM79 TMPRSS2 TMPRSS4 UPK2 VSIR ZFPL1	56 interacting genes: ADAP1 ADAP2 APC AR ATM AXL BACE1 BRCA1 CACNA1G CALB1 CBS CCND1 CDK11B CLEC7A DDX4 DISC1 DYRK1B ENTPD1 ESR1 EXOC2 FMR1 HIPK2 HMBS HNF4G ITGAL ITGB2 L1CAM LMNA MAPK6 MET MPHOSPH8 NCOA6 NCOR2 NSRP1 PPARD PPARG PPP1CA PRKACA RAF1 RAN S100A7 SMAD2 SMAD3 SMAD9 SOS1 SPOP SPP1 TFRC THRA THRB TP53 TP73 UCHL1 USP11 WNK1 YPEL5
Entrez ID		64581	10048
HPRD ID		08396	04835
Ensembl ID		ENSG00000172243	ENSG00000010017
Uniprot IDs		A0A024RAN9 A0A0S2Z5Q1 Q68D78 Q9BXN2	A0A024QZW3 Q96S59
PDB IDs			5JI7 5JI9 5JIU
Enriched GO Terms of Interacting Partners?
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