ARAP3 and GGA3

Data Source:
BioGRID (two hybrid)

		ARAP3	GGA3
Description		ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3	golgi associated, gamma adaptin ear containing, ARF binding protein 3
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GO Annotations	Cellular Component	Ruffle Cytosol Cytoskeleton Plasma Membrane Lamellipodium	Lysosome Golgi Apparatus Trans-Golgi Network Endosome Membrane Early Endosome Membrane Protein-containing Complex Recycling Endosome Membrane
	Molecular Function	GTPase Activator Activity Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Phosphatidylinositol-3,4-bisphosphate Binding Metal Ion Binding	Protein Binding Small GTPase Binding Ubiquitin Binding Protein-containing Complex Binding
	Biological Process	Cytoskeleton Organization Signal Transduction Vesicle-mediated Transport Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction	Protein Targeting To Lysosome Intracellular Protein Transport Regulation Of Protein Stability Protein Destabilization Endocytic Recycling Protein Localization To Cell Surface Golgi To Plasma Membrane Protein Transport Cellular Protein Metabolic Process Positive Regulation Of Protein Catabolic Process Negative Regulation Of Amyloid-beta Formation
Pathways		Rho GTPase cycle	TBC/RABGAPs MET receptor recycling Amyloid fiber formation
Drugs
Diseases
GWAS		Cerebral amyloid deposition (PET imaging) ( 26252872) Diffuse large B cell lymphoma ( 25261932) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Household income ( 31844048) Lung cancer ( 28604730) Mean arterial pressure ( 27618448) Offspring birth weight ( 31043758)
Interacting Genes		10 interacting genes: ANKS1A ARHGEF6 CD2AP CLNK GGA3 INPPL1 PARD6B SAMHD1 SH3KBP1 TNKS2	38 interacting genes: ADRA2A ADRA2B AFTPH AP1S2 ARAP3 ARF1 ARF3 CDKN2A CLINT1 CLTC CYTH2 DAZAP2 EGFR GGA1 GGA2 IGF2R LITAF LRP10 M6PR P4HA3 PACS1 PLEKHB2 RABEP1 RNF11 RNF214 RPS27A STAB1 SYNRG TBC1D3 TOLLIP TRAPPC6A TRIM23 TSG101 UBC UPRT VPS11 VPS18 ZNF497
Entrez ID		64411	23163
HPRD ID		09441	10443
Ensembl ID		ENSG00000120318	ENSG00000125447
Uniprot IDs		Q05CH1 Q8WWN8 Q9H7C1	A8K6M0 B7Z456 Q9NZ52
PDB IDs		2KG5 2LNW 5JCP 5JD0 7A9B	1JPL 1JUQ 1LF8 1P4U 1WR6 1YD8
Enriched GO Terms of Interacting Partners?
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