ARAP3 and INPPL1

Data Source:
BioGRID (pull down, pull down)

		ARAP3	INPPL1
Description		ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3	inositol polyphosphate phosphatase like 1
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GO Annotations	Cellular Component	Ruffle Cytosol Cytoskeleton Plasma Membrane Lamellipodium	Nucleus Golgi Apparatus Cytosol Cytoskeleton Plasma Membrane Nuclear Speck Lamellipodium Filopodium
	Molecular Function	GTPase Activator Activity Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Phosphatidylinositol-3,4-bisphosphate Binding Metal Ion Binding	Actin Binding Protein Binding Hydrolase Activity SH3 Domain Binding SH2 Domain Binding
	Biological Process	Cytoskeleton Organization Signal Transduction Vesicle-mediated Transport Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction	Endochondral Ossification Immune System Process Glucose Metabolic Process Phosphatidylinositol Biosynthetic Process Endocytosis Actin Filament Organization Cell Adhesion Negative Regulation Of Cell Population Proliferation Post-embryonic Development Negative Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Response To Insulin Inositol Phosphate Metabolic Process Phosphatidylinositol Dephosphorylation Ruffle Assembly
Pathways		Rho GTPase cycle	Synthesis of PIPs at the plasma membrane Synthesis of IP3 and IP4 in the cytosol Interleukin receptor SHC signaling
Drugs
Diseases
GWAS		Cerebral amyloid deposition (PET imaging) ( 26252872) Diffuse large B cell lymphoma ( 25261932) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Household income ( 31844048) Lung cancer ( 28604730) Mean arterial pressure ( 27618448) Offspring birth weight ( 31043758)	Heart rate response to recovery post exercise (10 sec) ( 29497042)
Interacting Genes		10 interacting genes: ANKS1A ARHGEF6 CD2AP CLNK GGA3 INPPL1 PARD6B SAMHD1 SH3KBP1 TNKS2	21 interacting genes: ABL1 AR ARAP3 BCAR1 CBL CD4 CSF1R EGFR ERBB2 ERBB3 ERBB4 FCGR2B FLNC GAB1 HID1 MET SHC1 SORBS1 SORBS3 SRC UBC
Entrez ID		64411	3636
HPRD ID		09441	02900
Ensembl ID		ENSG00000120318	ENSG00000165458
Uniprot IDs		Q05CH1 Q8WWN8 Q9H7C1	O15357
PDB IDs		2KG5 2LNW 5JCP 5JD0 7A9B	2K4P 2KSO 2MK2 3NR8 4A9C 5OKM 5OKN 5OKO 5OKP
Enriched GO Terms of Interacting Partners?
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