CXCL9 and CCR3

Data Source:
HPRD (in vitro)

		CXCL9	CCR3
Description		C-X-C motif chemokine ligand 9	C-C motif chemokine receptor 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space External Side Of Plasma Membrane	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane
	Molecular Function	Cytokine Activity Protein Binding Chemokine Activity CXCR Chemokine Receptor Binding CXCR3 Chemokine Receptor Binding	Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-C Chemokine Binding
	Biological Process	Chemotaxis Defense Response Inflammatory Response Cellular Defense Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Neutrophil Chemotaxis Regulation Of Cell Population Proliferation Positive Regulation Of Myoblast Differentiation Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Defense Response To Virus Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Positive Regulation Of Myoblast Fusion	Positive Regulation Of Endothelial Cell Proliferation Chemotaxis Inflammatory Response Immune Response Cellular Defense Response Cell Adhesion G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Viral Process Calcium-mediated Signaling Positive Regulation Of Angiogenesis Cell Chemotaxis Chemokine-mediated Signaling Pathway
Pathways		Chemokine receptors bind chemokines G alpha (i) signalling events	Chemokine receptors bind chemokines G alpha (i) signalling events
Drugs
Diseases
GWAS		Blood protein levels ( 28240269) Hippocampal volume ( 29274321) Neonatal cytokine/chemokine levels (fetal genetic effect) ( 30134952)	Arthritis (juvenile idiopathic) ( 33106285) Basophil count ( 32888494) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 32888494 27863252) Behcet's disease ( 23291587) Blood protein levels ( 28240269) Bone mineral density (Ward's triangle area) ( 27397699) Celiac disease ( 22057235 20190752 25920553 24999842 18311140) Celiac disease and Rheumatoid arthritis ( 26546613) Cerebrospinal fluid levels of Alzheimer's disease-related proteins ( 25340798) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Inflammatory bowel disease ( 26192919) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Monocyte chemoattractant protein-1 levels ( 23017229) Monocyte count ( 29403010 27863252) Narcolepsy with cataplexy ( 25986216) Obesity-related traits ( 23251661) Ulcerative colitis ( 26192919 28067908) White blood cell count (basophil) ( 27863252)
Interacting Genes		76 interacting genes: AMIGO1 AQP6 ATP1B4 BMF BSCL2 BTNL9 C16orf92 CCL11 CCL13 CCL2 CCL21 CCL26 CCL28 CCL5 CCR3 CD33 CHODL CLDN2 CLDN5 CLDN7 CLEC17A CLEC2D CLEC4E CLEC7A CXCL10 CXCL11 CXCL12 CXCL14 CXCL17 CXCL2 CXCR3 DPP4 EPGN EREG FBXO7 FCGR2A FFAR2 FNDC9 FUT7 GJB1 GORAB GPR42 IFNGR2 ITM2C KASH5 KIR2DL3 LDLRAD1 LEUTX LRRC25 LSMEM2 MR1 MTIF3 MUC1 NEMP1 PAX8 PF4 PPBP PTPN5 RHCG SFTPC SLC10A1 SLC39A1 SSMEM1 SUSD3 SYNE4 TM4SF18 TMED5 TMEM106C TMEM234 TMEM237 TMEM31 TMPRSS2 TNFSF14 TNFSF8 TSPAN18 XCL1	19 interacting genes: CCL11 CCL13 CCL14 CCL15 CCL2 CCL24 CCL26 CCL28 CCL3 CCL3L1 CCL4 CCL5 CCL7 CCL8 CXCL10 CXCL11 CXCL9 FGR HCK
Entrez ID		4283	1232
HPRD ID		03416	03167
Ensembl ID		ENSG00000138755	ENSG00000183625
Uniprot IDs		Q07325	A1LPE5 P51677 Q8TDP4 Q8TDP5
PDB IDs
Enriched GO Terms of Interacting Partners?
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