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SET and UCHL5
Data Source:
BioGRID
(pull down)
SET
UCHL5
Description
SET nuclear proto-oncogene
ubiquitin C-terminal hydrolase L5
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Endoplasmic Reticulum
Lipid Droplet
Cytosol
Protein-containing Complex
Perinuclear Region Of Cytoplasm
Proteasome Complex
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Ino80 Complex
Molecular Function
DNA Binding
Chromatin Binding
Protein Phosphatase Inhibitor Activity
Protein Binding
Protein Phosphatase Regulator Activity
Histone Binding
RNA Binding
Thiol-dependent Ubiquitin-specific Protease Activity
Endopeptidase Inhibitor Activity
Protein Binding
Cysteine-type Peptidase Activity
Proteasome Binding
Biological Process
DNA Replication
Nucleosome Assembly
Nucleosome Disassembly
Viral Process
Negative Regulation Of Phosphoprotein Phosphatase Activity
Negative Regulation Of Histone Acetylation
Regulation Of MRNA Stability
Negative Regulation Of Neuron Apoptotic Process
Negative Regulation Of Transcription, DNA-templated
DNA Repair
DNA Recombination
Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Endopeptidase Activity
Protein Deubiquitination
Protein Phosphopantetheinylation
Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Smoothened Signaling Pathway
Regulation Of Proteasomal Protein Catabolic Process
Pathways
Condensation of Prophase Chromosomes
HuR (ELAVL1) binds and stabilizes mRNA
Downregulation of TGF-beta receptor signaling
UCH proteinases
UCH proteinases
Drugs
Diseases
GWAS
Axial length (
24144296
)
Body mass index (
26426971
)
Eating disorders (purging via substances) (
23568457
)
Cannabis dependence (
21668797
)
Interacting Genes
68 interacting genes:
ANP32A
APEX1
APP
CALM1
CDCA8
CDK5
CDK5R1
CDKN1A
CHAF1A
CHRM2
CHRM3
ELAVL1
ELF4
ENO1
EP300
ESR1
FAM111B
FBXO7
FOS
FOXO1
GZMA
GZMK
H1-1
H2BC1
H3-3A
H3-4
H4-16
H4C14
HMGB2
IRF1
JUNB
KLF5
KMT2A
LGMN
MDM2
MEOX2
MTERF1
NME1
NUCB1
NUPR1
PAX6
PIK3CG
PPP2CA
PPP2R1B
PRKAR1A
PTEN
PTMA
RAC1
REPIN1
SDCBP
SETBP1
SGO1
SGO2
TAF1A
TERF1
TERF2
TERF2IP
TEX35
THAP7
TLE5
TREX1
TRIM55
TRIM63
UCHL5
XRCC6
ZNF17
ZNF438
ZNF85
102 interacting genes:
ACTN4
ADRM1
ANP32B
ANP32E
ANXA1
ANXA4
ANXA7
ANXA8
ANXA8L1
APP
ARG1
ASPRV1
CALM1
CAP1
CAPZA1
CASP14
CDSN
CFL1
CSTA
DSC1
DSC3
DSP
DUSP14
E2F1
E2F2
E2F3
EEF1G
EEF2
EIF4A1
EPPK1
FLG
GSTM3
H4-16
H4C1
H4C11
H4C12
H4C13
H4C14
H4C15
H4C2
H4C3
H4C4
H4C5
H4C6
H4C8
H4C9
HAUS7
HBA1
HBA2
HBB
HSPB1
IDE
IGHG1
IVL
KDM1A
KRT12
KRT19
KRT26
KRT28
KRT73
KRT78
KRT80
LMNA
MAP3K1
NACA
NFRKB
PJA1
PKM
PKP1
PLA2G2A
PNP
POF1B
PRDX6
PSMD8
RAB7A
RBCK1
RFFL
S100A14
S100A16
S100A7
SERPINB12
SERPINB3
SERPINB5
SET
SMAD2
SMAD3
SMAD7
TCF7
TGM3
TPI1
TRIM27
TRIM46
TRIM54
TRIM55
TRIM63
TUBA4A
TXN
TXN2
UBC
USP28
YWHAZ
ZBED1
Entrez ID
6418
51377
HPRD ID
09023
10293
Ensembl ID
ENSG00000119335
ENSG00000116750
Uniprot IDs
A0A024R895
A0A0C4DFV9
Q01105
Q5VXV3
Q9Y5K5
PDB IDs
2E50
3A7S
3IHR
3RII
3RIS
3TB3
4UEL
4UEM
4UF5
4UF6
4WLP
Enriched GO Terms of Interacting Partners
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